Sentences with phrase «new gene functions»

For several decades, much attention has been placed on gene duplication as a source of new gene functions.

In the paper, the model is used to demonstrate a number of these approaches, including detailed investigations of DNA - binding protein dynamics and the identification of new gene functions.

Not exact matches

The EC has historically supported IRRI's work to conserve the genetic diversity of rice, understand the function of rice genes, and develop new rice varieties, particularly for use in difficult growing environments.

It has been estimated that 5 % to 10 % of infants who die from SIDS have novel mutations in the cardiac sodium or potassium channel genes that result in long QT syndrome as well as in other genes that regulate channel function.44 A recent report described important new molecular and functional evidence that implicates specific SCN5A (sodium channel gene) β subunits in SIDS pathogenesis.47 The identification of polymorphisms in genes pertinent to the embryologic origin of the autonomic nervous system in SIDS cases also lends support to the hypothesis that a genetic predisposition contributes to the etiology of SIDS.

In the new research, the UB scientists found they could reverse those social deficits with a very low dose of romidepsin, which, they found, restores gene expression and function using an epigenetic mechanism, where gene changes are caused by influences other than DNA sequences.

«Decoding the genome's cryptic language: New tool to map RNA - DNA interactions could help researchers translate gene sequences into functions.»

When a new gene arises on the X chromosome (males have one X chromosome and females two) it is likely to cease functioning much faster than genes that arise on other chromosomes.

These strands, known as oligonucleotides, take only a day or two to prepare and can be used to create custom genes to give cells new functions.

A new report by researchers in the Perelman School of Medicine at the University of Pennsylvania found that loss - of - function mutations to Filaggrin - 2 (FLG2), a gene that creates a protein responsible for retaining moisture and protecting the skin from environmental irritants, were associated with atopic dermatitis in African American children.

Better understanding of the association between genes, lung function and lung diseases The identified genes open up new molecular biological approaches for a better understanding of lung development and of the repair and remodelling processes during disease pathogenesis.

After extensive analysis of this new gene, the team discovered that moc1 functions as a chloroplast - specific «Holliday junction resolvase», which Nishimura continues, «is very important in untangling a DNA structure called Holliday junctions.

The new approach could look directly at the toxic strain's genes to see how they functions.

They interact with existing genes to create some new function.

A decade of post-genomic biology has also focused new attention on the regions outside protein - coding genes, many of which are likely to have key functions, through regulating the expression of protein - coding genes and by making a slew of non-coding RNA molecules.

The article published on the journal Molecular Biology and Evolution provides the framework for posing new hypotheses on the phylogenetic relations among poriferans, determining gene function in sponges and the early evolution of molecular complexity in metazoans.

For his part, Collins, who has led NIH since 2009 and been kept on by the Trump administration, pointed to an array of promising NIH activities, including the development of new technologies to provide insights into human brain circuitry and function through the Brain Research through Advancing Innovative Neuroethologies (BRAIN initiative) and the use of the gene - editing tool CRISPR - Cas9 to correct mutations and clear the way to develop and test a «curative therapy» for the first molecular disease: sickle cell disease.

The cut DNA is then either left as - is, silencing it, or repaired by using the gene editor to slip in a new, functioning segment.

«New innovative method for delivering genes into cells: Modification of cell physiological function with novel parallelized electroporation of mammalian cells by using electrostatic manipulation in a water - in - oil droplet.»

Monsanto's newest drought - tolerant product, Drought Guard, relies on a gene that creates a chaperone protein to coat a plant's RNA during stressful conditions and maintain the plant's normal cell functions, while Syngenta's hybrid contains novel drought - tolerant gene combinations.

These data suggest that new genes frequently and rapidly evolve essential functions and participate in development.

One gene that controls this pathway, HDAC7, is known to be a key factor in immune tolerance and the new data strongly suggests exploring the possibility that drugs affecting HDAC7 function may serve as future therapeutics in PSC.

Large - scale methods of probing samples, such as DNA sequencing, microarrays, and automated gene - function studies, are filling new databases to the brim.

Over the longer term, the identification of the coffee tree genome sequence opens up new possibilities for varietal improvement, knowledge of the specific functions of the genes (in particular those specific to coffee trees), the possibility of transferring results to other species, and refining diagnostic tools for the function of the plant.

The three Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.

By identifying novel genes and molecular pathways involved in shaping a taste cell's function, these findings may someday allow scientists to treat taste disorders, characterize new taste qualities, or even fine - tune a person's taste perception to encourage healthier eating.

Matches between new genes from other species, including mammals, and these E. coli sequences have often helped researchers pin a name and function on their discoveries.

A given gene may perform a different function in breast cancer cells than in healthy cells due to changes in networks of interacting proteins, according to a new study published in PLOS Computational Biology.

For the manatee, walrus, dolphin, and killer whale, the return to the sea involved many evolutionary trade - offs amongst hundreds of genes: a general loss of the number of sensory genes for smell and taste, new functions for genes forming skin and connective tissue, and genes involved in muscle structure and metabolism.

This is an example where each function you know, became optimized, but there are ways, there are reasons why gene duplication can also create nothing new, whatsoever.

Some duplicated genes were lost over time but others took on new functions, including contributions to the development of floral organs.

«Because many broadly expressed genes that play key roles in essential cellular functions are under the control of cell - specific enhancers, the ability to affect enhancer function by knocking down eRNAs could potentially provide a new strategy for altering gene expression in vivo in a cell - specific manner,» said Glass, noting that in his research, anti-sense oligonucleotides were developed in conjunction with Isis Pharmaceuticals, which suppressed enhancer activity and reduced expression in nearby genes.

Its still material that natural selection can work with in the future and yeah, there are ways for genes to acquire new functions long after they've been duplicated.

A new function now described for the protein dDsk2 by the team headed by Ferran Azorín, group leader at the Institute for Research in Biomedicine (IRB Barcelona) and CSIC research professor, links ubiquitin receptors for the first time with the regulation of gene expression.

Until recently, biologists had thought that different genes drove each instance of echolocation and that the relevant proteins could change in innumerable ways to take on new functions.

The new Salk tool, called CasRx, opens up the vast potential of RNA and proteins to genetic engineering, giving researchers a powerful way to develop new gene therapies as well as investigate fundamental biological functions.

And that got us into this broad question of: How do new genes» functions evolve?»

According to Abouheif, Khila didn't just show that this new gene makes the water striders» fan; he also «reconstructs its evolutionary history, and then does the trademark ecological tests to show that it has an ecological function.»

That surprisingly low number suggested the evolution of new species was accompanied by rapid turnover of the venom genes, with old genes being abandoned and new ones with novel venom functions suddenly arising.

Researchers at Stockholm University and Science for Life Laboratory have developed a new computer algorithm for analysing gene function called BinoX, which was e-published in Nucleic Acids Research on September 22 (Ogris et al., 2016a).

It can take up to a year to determine the function of a single gene, which has slowed efforts to develop new, more targeted drugs and vaccines.

Using a new powerful technique, the Lund researchers have now been able to analyse practically the entire methylome and measure individual gene function and expression.

«To address this problem, our lab has developed new methods to predict gene and protein functions.»

Synthetic biology is a promising new tool to study the function and properties of gene regulatory networks (GRNs) by building them from first principles.

Researchers led by Baylor College of Medicine have developed a new computational method to study the function of disease - causing genes, starting with an important new discovery about a gene associated with malaria — one of the biggest global health burdens.

RNAi became a new tool for turning off genes in worms to study their functions.

Then, while the pre-existing genes kept the species viable, the extra gene copies could evolve new functions, thus speeding evolutionary change.

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

«Our study sheds new light on how genes normally function in sperm stem cells,» says Cairns.

A study investigating the function of the recently discovered enhancer RNA molecules may open new avenues for gene therapy.

A study by Dr. Wendy Chung has identified six new mutations in a gene called KCNK3 that can interfere with the function of potassium channels and lead to pulmonary hypertension.