Not exact matches
The
new locus they have identified is near a cluster of
genes which code for proteins called «glycophorins» that are involved in the malaria parasite's invasion of red blood cells.
«This
new resistance
locus is particularly interesting because it lies so close to
genes that are gatekeepers for the malaria parasite's invasion machinery.
But when we put these genetic associations alongside the ENCODE data, we saw that although the
loci are not close to a protein - coding
gene, they really are close to one of these
new elements that we're discovering.
our stroke research, we will soon be able to find a
gene within the type 2 diabetes
locus we have identified and use this
gene to identify powerful
new drug targets.»
Sequences for 54 nuclear
genes were taken from Perelman et al.'s [12] nexus file with modifications to eliminate problems with probable contaminants and misidentified sequences (Table S2); sequences for 15 additional nuclear
genes (ABO, CXCR4, CXCR5, Epsilon globin, FGA, IRBP intron 1, IRBP intron 3, MC1R, NRAMP, PRNP, VWF intron 11) were obtained from GenBank; and
new sequences (JX856181 - JX856283, JX869897 - JX869930) for exons of four nuclear
genes (GHR, IRBP, VWF, TTN) were combined with previously published GenBank sequences for these
loci.
Dr. Radislav Sedlacek and his team from the Institute of Molecular Genetics has recently published
new paper on
gene targeting of Rosa26
locus using TALENs.
In addition, many associated
loci contain
genes that were hitherto unrecognized as playing a role in fibrosis, opening up
new avenues of research that may lead to novel treatments for DD and fibrosis more generally.