Sentences with phrase «new gene models»

(A — B) An example of new gene models generated for Olfr168 (A) and Vmn1r34 (B) are shown in black.

We therefore assessed whether our new gene models will help resolve this by determining the proportion of each gene sequence that is unique in the genome.

Not exact matches

Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.

A new mouse model of a genetically - linked type of autism reveals more about the role of genes in the disorder and the underlying brain changes associated with autism's social and learning problems.

This is advantageous, since dogs provide new models to investigate the disease mechanisms and to plan new therapies such as gene therapy, successfully applied to blindness in dogs and human previously,» explains Lohi.

«Our study validates using fruit flies as a model to discover new genes that may also control aggression in humans.»

Using a new technique to deliver gene - therapy - like intervention directly where it's needed, researchers at Thomas Jefferson University successfully increased or decreased the muscle tone of the anal sphincter in appropriate animal models.

The research opens the possibility of a new model organism for human heart health and the distant prospect of incorporating such a gene into humans.

In the current work, they used a new variation of the gene - editing system to repair the defect in both a mouse model and in human cells.

With the advent of new gene editing techniques, some less common animal models such as octopuses may find their way into scientists» toolkits.

Furthermore, the cells offer a renewable, long - lasting model system for testing drug candidates or gene modifications that may offer new treatments, personalized to individual patients.

«New gene editing technique turns human pluripotent stem cells into a model system for polycystic kidney disease.»

With their new fruit fly research model, the UNC researchers altered the histone gene so that this particular enzyme could not modify its histone protein target.

UT Southwestern Medical Center researchers successfully used a new gene editing method to correct a mutation that leads to Duchenne muscular dystrophy (DMD) in a mouse model of the condition.

«The new FOP model already has shed light on the disease process in FOP by showing that the mutated gene can affect different steps of bone formation,» Hsiao said.

Researchers from the Eaton - Peabody Laboratories of the Massachusetts Eye and Ear and Harvard Medical School have created a new mouse model in which by expressing a gene in the inner ear hair cells — the sensory cells that detect sound and sense balance — protects the mice from age - related hearing loss (ARHL) and noise - induced hearing loss (NIHL), the two most common forms of deafness.

The study, conducted using fruit fly populations bred to model natural variations in human sleep patterns, provides new clues to how genes for sleep duration are linked to a wide variety of biological processes.

The significance of the new model, according to Grange, is that «it enables us to now have a biological understanding of the patterns, the co-expression profiles, seen in the Allen Gene Expression Atlas of the Mouse Brain.»

«Given the similarities in the molecules and the mechanisms involved in limb development in vertebrates and invertebrates, the fly is a very useful genetic model in which to identify new genes that potentially participate in limb development in vertebrates and their possible association with congenital diseases,» says Ana Ferreira, who has participated in the study.

With chronically infected mice as their model, the researchers used a new technology called ATAC - seq to map the regulatory regions of the genome — the sections of DNA involved in switching genes on and off — in the animals» exhausted and functional CD8 + T cells.

Carroll: That's right and we are just understanding that there is a lot more trajectories open, so yeah, sort of a long - standing model, it was just as you said, that you sort of would keep one gene to do all the old jobs and play with the new gene, but it turns out that we are appreciating a lot more.

«Our aim now is to study the role of these new gene switches in disease models.»

The new finding is the latest evidence supporting a growing precision medicine model of psychiatric disease in which disruptions of certain genes during brain development contribute to a person's risk for multiple psychiatric disorders, with other genetic or epigenetic drivers, random developmental events, or environmental influences determining the specific disease an individual develops, said senior author Benjamin Cheyette, MD, PhD, an associate professor of psychiatry and a member of the UCSF Weill Institute for Neurosciences and the Kavli Institute for Fundamental Neuroscience at UCSF.

But new findings published recently in Current Biology challenge this model, finding that the majority of toxin genes for parasitoid wasp species are instead «moonlighting» from other physiological roles.

In the new model of biology, proteins still do the hard work of catalyzing reactions and switching genes on and off, but the microRNAs regulate the amount of proteins and hence how much of each specific job is done.

But gene therapy companies - which also include Bluebird Bio, BioMarin, Sangamo and GenSight - may need new business models.

For the new mouse model, the researchers exposed adolescent mice with at least one copy of a variant of the BDNF gene, which has been associated with anorexia and anxiety in mice and humans, to social stress and caloric restriction.

Many studies have investigated the role of immunity in ALS, and our finding that a gene regulating the immune response is important in this canine model of ALS could provide a new angle says Emma Ivansson.

Noting the potential of gene therapy to be a one - time treatment for rare and serious diseases that otherwise cost hundreds of thousands, if not millions, of dollars in chronic care over a lifetime, Stuart Orkin, MD, and co-author Philip Reilly, MD, JD, of Third Rock Ventures, seek to «catalyze the discussion» by suggesting several new models for valuing, pricing and developing gene therapy.

Using a genome - wide approach in a new dog model for copper toxicosis, a team of researchers led by Hille Fieten have now revealed that mutations in a copper transporter gene, ATP7A, can ameliorate symptoms of the disease.

The study also presents a new model that explains how growth promoting genes could be epigenetically turned on and growth inhibiting genes could be epigenetically turned off in cancer cell formation.

The results of their work, the researchers say, may advance scientific understanding of how genes linked to the risk of human bipolar disorder change neuronal circuits in the brain, and may offer an animal model for testing new treatments.

«New dynamic statistical model follows gene expressions over time: Future applications could range from fMRI data to social networks and more.»

Researchers at Carnegie Mellon University have developed a new dynamic statistical model to visualize changing patterns in networks, including gene expression during developmental periods of the brain.

The results, published in the current issue of Human Molecular Genetics, open the door for pursuing gene editing in nonhuman primates as models for new therapies, including pharmacological, gene - and stem cell - based therapies, said Keith Latham, MSU animal science professor and lead author of the study.

Yehoash Raphael, an auditory neuroscientist at the University of Michigan, Ann Arbor, says the findings provide a new delivery model for researchers trying to use developmental genes to restore lost hearing.

Developing a new dynamic statistical model to follow neural gene expressions over time is one of the many brain research breakthroughs to happen at Carnegie Mellon.

«The Medaka experiment finding of new genes affected by microgravity provides a good animal model to clarify this mechanism.»

A new mathematical model uses gene expression data to predict where neurons are located throughout the brain

The researchers» strategy — generating disease - specific nerve cells, identifying a causative gene for developmental defects, validating the gene - specific defect in animal models, and then investigating interactions with other genes both in animal models and in humans — represents a promising new approach for understanding the mechanisms underlying some of the most intractable psychiatric illnesses.

Increased expression of a gene linked to autism spectrum disorders (ASDs) leads to a remodeling of dendrites during brain development, according to a new study conducted in cultured neurons and an ASD mouse model published in JNeurosci.

Dubbed model - organism ENCODE (modENCODE), this new focus will apply innovative methods and technologies for the study of gene regulation to the smaller, and therefore more manageable, genomes of the fruit fly (Drosophila melanogaster) and the round worm (Caenorhabditis elegans).

«To move beyond cataloging microbes, we will need new tools to rapidly determine microbial gene function and monitor the chemicals microbes use to communicate and interact with their environment, and new ways to visualize and model those interactions,» said Eoin Brodie, a staff scientist at Lawrence Berkeley National Laboratory's Earth Sciences Division and an author of the proposal.

It is also intended for post-docs and scientists already working in certain of these fields and who are interested in expanding their knowledge on the potential applications of these new techniques to their models or in neighbouring pathophysiological models of analysis of genes or diseases using genetically modified animals.

In the paper, the model is used to demonstrate a number of these approaches, including detailed investigations of DNA - binding protein dynamics and the identification of new gene functions.

We have developed a new mouse model harboring a high number of MAIT cells that are also fluorescent by introgressing both a wild mouse gene and a ror (gt) GFP transgene.

With the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic development.

The goal of the program is to discover gene - based biomarkers that can predict outcomes, estimate treatment toxicities, speed discovery of new drugs and create a model that could be reproduced at academic medical centers across the nation.

Identifying a full list of imprinted genes for humans and model organisms will give scientists a springboard to characterize the mechanisms and functions of imprinting, says Ian Morison of the University of Otago in Dunedin, New Zealand.

Use of genetically modified rodents for gene validation - New approaches for time saving and models of higher relevancy