Sentences with phrase «new generation sequencing»

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This new technology is dubbed next generation sequencing.

«Our work demonstrates that the generation of genome sequences from a large number of archaic human individuals is now technically feasible, and opens the possibility to study Neandertal populations across their temporal and geographical range,» says Janet Kelso, the senior author of the new study.

The next generation of sequencing technology will take results to a new level

The new study, led by Johannes Krause, a geneticist at the Max Planck Institute for the Science of Human History in Jena, Germany, used next - generation sequencing methods to read stretches of any DNA present in a sample and fish out those that resembled human DNA.

His laboratory develops and deploys new biochemical and computational methods in functional genomics, to elucidate the genetic basis of human disease and human physiology, and to create and deploy novel techniques in next - generation sequencing and algorithms for tumor evolution, genome evolution, DNA and RNA modifications, and genome / epigenome engineering.

Using next - generation sequencing technologies that were previously unavailable, Michael Gardner, a graduate research assistant, and Jianying Wang, a senior research associate in Mitchum's lab, made a remarkable new discovery — nematodes possess the ability to produce a second type of peptide that can effectively «take over» plant stem cells that are used to create vital pathways for the delivery of nutrients throughout the plant.

«The sequence will make it possible to develop new, more effective selective breeding tools that will make us even better at choosing parent fish with desired traits for the next generation of salmon,» says Mr Arnesen.

Dr. Funari's research interests include developing new approaches for obtaining mycobiome profiles in human disease and the translation of next generation sequencing applications into the clinic and personalized medicine.

Existing technology, known as next - generation sequencing (NGS), measures genomes derived from millions of cells versus the newer method for single - cell sequencing, called Monovar.

Researchers from Sanford Health and Chronix Biomedical today announced that results from a pilot study demonstrating the utility of a new cancer panel to detect previously undetected viral and cancer mutations are to be reported in a poster presentation titled «Detection of novel HPV mutations and chromosomal number imbalance (CNI) in oropharyngeal and laryngeal cancer using next - generation sequencing (NGS)» at the American Society of Clinical Oncology Annual Meeting (ASCO 2014) being held from May 30 through June 3, 2014 in Chicago.

The convergence of several factors explains the trend: cheaper genetic sequencing technologies, the discovery of new oncogenes (genes that can cause a normal cell to become cancerous), a new generation of computers and bioinformatics that can analyze vast amounts of data, and a multibillion - dollar effort by researchers inside and outside the pharma industry to develop targeted drugs and companion diagnostics for cancer.

The use of next - generation gene sequencing in newborns in neonatal intensive care units (NICUs) may improve the diagnosis of rare diseases and deliver results more quickly to anxious families, according to new research in CMAJ (Canadian Medical Association Journal).

Dr. James Beck of Wichita State University and Dr. John Semple, at the University of Waterloo, have collaborated on a new study highlighting the role of herbarium sampling coupled with cutting - edge next - generation sequencing technologies to better understand plant diversity.

«Next - generation sequencing technology has allowed us to find new causes of genetic diseases in much smaller families,» explained the study's lead author, William Motley, MD, PhD, a resident physician in Medicine.

«Our results using advanced, modern laboratory techniques called next - generation sequencing, allowed us to acquire a library of new knowledge about patients with ALS,» says the study's senior author, Leonard Petrucelli, Ph.D., chair of the Department of Neuroscience on Mayo Clinic's Florida campus.

Genome researcher Elaine Mardis of Washington University in St. Louis in Missouri cautions that because the 1000 Genomes Project participants» genomes weren't sequenced in depth and were done when next - generation sequencing technologies were very new, MacArthur's team may have missed some loss - of - function variants.

Using next - generation sequencing, the U.K. team showed that the iPS cells» genome was «clean» — the gene - editing methods had not added any new mutations.

New sequence of the endangered marsupial's genome could help future generations fight off devastating facial tumor disease

In a separate study which is not yet published, this team with Professor Steve Rozen, from the NBD Programme at Duke - NUS, identified many new mutations in the PCM1 gene from ASD patients from next - generation sequencing.

And next - generation sequencing, in particular, RNA sequencing, allows researchers to delineate changing patterns of gene expression as new cell types form.

SNP calling, genotype calling, and sample allele frequency estimation from new - generation sequencing data Nielsen, R. T. Korneliussen, A. Albrechtsen, Y. Li et al. 2012.

Based on detailed molecular analyses, including next - generation sequencing, of 385 children with de novo AML enrolled in the prospective ELAM02 trial, a new molecular classifier for pediatric AML is proposed.

Yufeng Shen, Peter Sims, and Chaolin Zhang have designed a new team - taught course that covers both the experimental and analytical basics of next - generation sequencing.

It currently analyses a panel of multiple cancer predisposition genes thanks to new - generation sequencing techniques.

Moreover, we demonstrated that although the Oxford Nanopore technology is a relatively new sequencing technology, currently with a high error rate, it is already useful in the generation of high - quality genome assemblies.

April 2012 - New research: Illuminating embryonic stem cells Collaboration between two EU funded projects «Heroic» and «EuroSyStem», has provided new insights into embryonic stem cells The teams used next generation sequencing technology to examine two key properties of the cells that influence their identity and behaviour: gene expression and gene regulatiNew research: Illuminating embryonic stem cells Collaboration between two EU funded projects «Heroic» and «EuroSyStem», has provided new insights into embryonic stem cells The teams used next generation sequencing technology to examine two key properties of the cells that influence their identity and behaviour: gene expression and gene regulatinew insights into embryonic stem cells The teams used next generation sequencing technology to examine two key properties of the cells that influence their identity and behaviour: gene expression and gene regulation.

Therefore, I am engaged in using, developing and combining new technologies, including: (1) super-resolution microscopy, (2) single molecule imaging, (3) genetic engineering, (4) next generation sequencing approaches and (5) mathematical and biophysical modeling.

Ongoing T2D research activities at CRGGH include 1) whole - exome sequencing of African families with at least four affected members (data generation is complete and analysis is ongoing), 2) GWAS of 1,200 cases and 1,200 controls from West Africa using the new and more efficient African - centric Affymetrix Axiom genome - wide array with more than 2 million markers, and 3) whole genome expression analysis on skeletal muscle obtained from biopsy from 45 subjects (expression QTL (eQTL) studies on the dataset are complete).

Bertout proposes to use new barcoding technologies she developed in the Bielas Lab to build upon Next Generation Sequencing technologies and enable exquisitely sensitive cancer - specific mutation detection.

Newer methods, which leverage massively parallel sequencing approaches, are often referred to as Next - Generation Sequencsequencing approaches, are often referred to as Next - Generation SequencingSequencing (NGS).

New generation of sequencing technology uses nanopores to deliver ultra long read length single molecule sequence data, at competitive accuracy, on scalable electronic GridION platform.

Next - generation sequencing technologies are said to be ushering in a new era of cancer genomics.

They have brought online a new generation of Illumina sequencers and optimized their function to a level at which eight to 10 trillion DNA bases can be sequenced in a month.

Next - generation sequencing machines can now sequence an entire human genome in a few days, and this capability has inspired a flood of new projects aimed at sequencing the genomes of thousands of individual humans and a broad range of animal and plant species.

Information gained from this work will serve to enhance the clinical usefulness of findings from genomic sequencing (for example, next - generation sequencing or comprehensive genomic profiling), determine therapeutic approaches based on genomic findings, aid in the development of clinical trials and related options, and provide supportive rationale for exploring new therapies.

With the development of high - throughput technologies, such as Next Generation Sequencing (NGS), which allows to sequence entire genomes, the omics field is rapidly expanding and creating new perspectives for research and diagnosis.

New results from a research group lead by SciLifeLab faculty member Richard Rosenquist Brandell shows that next - generation sequencing technology can provide equally reliable results as previous methods.

We developed a new approach to sequence generation for targeted base updates and used data from new genome mapping technologies and single haplotype resources to identify and resolve larger assembly issues.

With the development of novel genomics technologies, such as Next - Generation Sequencing, numerous new mutations and gene expression signatures have been identified, allowing us to better understand the molecular heterogeneity of hematologic diseases and to better stratify and assess risk for cancer patients.

Here, we demonstrate the feasibility of classical genetic screening in mammalian systems by using haploid cells, chemical mutagenesis and next - generation sequencing, providing a new tool to explore mammalian genetic interactions.

ASHG 2011: Next - Generation Genome Sequencing Methods Reveal New Findings on Evolution and Population Genetics at ICHG / ASHG 2011 Meeting ASHG Press Briefing - October 13, 2011

Advances in 3rd generation sequencing have opened new possibilities for benchtop whole genome sequencing.

BETHESDA, Md., Nov. 7, 2003 - The National Human Genome Research Institute (NHGRI) today announced the selection of five centers to carry out a new generation of large - scale sequencing projects designed to maximize the promise of the Human Genome Project and dramatically expand our understanding of human health and disease.

Although next - generation sequencing has revolutionized the ability to associate variants with human diseases, diagnostic rates and development of new therapies are still limited by a lack of knowledge of the functions and pathobiological mechanisms of most genes.

Using high - throughput ChIP - Seq and chromatin property data, we are developing a new generation of bioinformatics methods for the identification of regulatory sequences.

Each science teacher teaches one grade level, developing a curriculum aligned to the New York City scope and sequence and integrating the Next Generation Science Standards.

Kaleidoscope: Colour and Sequence in 1960s British Art, a new exhibition at Longside Gallery in Yorkshire Sculpture Park, includes key works from this period in British art; often referred to as the «new generation».

2003 Not Exactly Photographs, Fraenkel Gallery, San Francisco, CA Drawing Modern: Works from the Agnes Gund Collection, Cleveland Museum of Art, Cleveland, OH Zen & Modern Art, University Art Gallery, California State University, Hayward, CA Beat Generation and Beyond, John Natsoulas Gallery, Davis, CA In Sequence, Michael Rosenfeld Gallery, New York, NY

(catalogue) Persona, The Renaissance Society at the University of Chicago, Chicago, IL; Kunsthalle Basel, Basel Switzerland 1995 It's How You Play The Game, Exit Art, New York; curated by Thelma Golden, Nancy Spector, Robert Storr, Jeanette Ingberman and Papo Colo Strung Into the Appolonian Dream... an exhibition of a private collection, Feature, NYC, NY Seven Llongish Wodden Sculptures, Feature, New York, NY 1994 The Ecstasy of Limits, Gallery 400, School of Art and Design, UIC, Chicago, IL Amenities, Frederick Layton Gallery, Milwaukee Institute of Art and Design, Milwaukee 1993 A Sequence of Forms: Sculpture by Illinois Artists, Chicago Cultural Center, Chicago, IL Mettlesome & Meddlesome: Selections from the Collection of Robert J. Shiffler, Contemporary Arts Center, Cincinnati, OH; Urbana - Champaign, IL; I Space, University of Urbana - Champaign Gallery, Chicago, IL 1992 Drawing New Conclusions, Betty Rymer Gallery, The School of the Art Institute of Chicago, Chicago, IL 1991 Office Party, (March) Feature, New York, NY Power: Its Icons, Myths and Structure in American Culture 1961 - 1991, Museum of Fine Art, Richmond VA: curated by Holliday T. Day (catalogue) 1990 Toward the Future Contemporary Art in Context, Museum of Contemporary Art, Chicago Awards in the Visual Arts, New Orleans Museum of Art, New Orleans, LA; Southeastern The Thing Itself, Feature, New York, NY (brochure) New Generations Chicago, Carnegie Mellon Art Gallery, Carnegie Mellon University, Pittsburgh, PA; curated by Elaine A. King (catalogue) Half - Truths, The Parrish Art Museum, Southhampton, NY; curated by Marge Goldwater 1989 On Kawara: Date Paintings 1966 - 1988, The Renaissance Society at the University of Chicago, Chicago, IL Signs of Life: Contemporary American Sculpture, Fundacao Calouste Gulbenkian; Fundacao Luso - Americana Para O Desenvolvimento, Lisbon, Portugal; curated by Judith Russi Kirshner.