The discovery of
new genes involved in these repair mechanisms is very important in order to understand the development of these tumours and delve more deeply into their therapeutic vulnerabilities.
The team identified eight
new genes involved in this type of epilepsy thanks to their use of whole - genome sequencing, which had never been done before in an epileptic study of this scope.
In this a genetic count was made of
new genes involved in the prevention of DNA - RNA hybrids, which cause genetic instability.
«The computational method we have proposed can be applied to other data - sets to predict
new genes involved in other conditions,» says Alessandra Mezzelani, a researcher involved in the study.
Moreno's first job in the lab — helping a postdoc develop a mutagenesis technique to identify
new genes involved in organ development and positioning — earned him a second - author paper in Science just a couple of years into his Ph.D..
Wang designed genetic screens that allowed her to find several
new genes involved in engulfment.
A European consortium of epilepsy researchers has reported the discovery of
a new gene involved in severe childhood epilepsy.
«The most exciting thing about our study is not that we've identified
a new gene involved in pulmonary hypertension, but that we've found a drug that can «rescue» some mutations,» said co-senior author Wendy K. Chung, MD, PhD, associate professor of pediatrics and medicine at CUMC.
«ANKRD55:
New gene involved in Multiple Sclerosis discovered.»
Researchers have found
a new gene involved in the development of insulin - dependent diabetes.
Not exact matches
It's also working in Beijing on
new technology in genome editing; unlike GMO technology, it doesn't
involve inserting a
gene from another species, such as a bacterium, into a plant.
Meanwhile, Editas founder Feng Zhang is a leader in an entirely
new approach to battle disease that
involves editing
genes.
The
newer process of genetic engineering, which
involves inserting
genes from unrelated species into a plant's genome to add desirable traits, has been used in crops such as corn, soy, and potatoes.
«In two studies of breast - fed infants
involving more than 3,000 children in Britain and
New Zealand, breastfeeding was found to raise intelligence an average of nearly 7 IQ points if the children had a particular version of a
gene called FADS2.
The
new work, says Fitch, is consistent with his prediction — he would love to know the
genes involved.
New research at the University at Buffalo reveals the first evidence that it may be possible to use a single compound to alleviate the behavioral symptoms by targeting sets of
genes involved in the disease.
Making a
new gene, for example, used to
involve months of toil and creativity.
Scientists are a step closer to discovering what determines the sex of Australia's iconic platypus and echidna, after an international study
involving researchers from the University of Adelaide and UNSW Australia unravelled
new genes contained on mammalian Y chromosomes.
So far, researchers have mostly turned on
genes with CRISPRa in cells growing in lab dishes, says Charles Gersbach, a biomedical engineer at Duke University not
involved in the
new study.
The
new gene permanently switched on a set of
genes normally affected by insulin and
involved in the immune system.
The JASONs»
gene - drive discussion
involved around 20 scientists, according to Philipp Messer, a population geneticist at Cornell University in Ithaca,
New York, who attended the meeting.
One clinical trial
involves the drug CGF166, a one - time
gene therapy, which, if proven successful in humans, could regenerate
new hair cells within the cochlea that can signal the part of the brain that processes sound.
«This is a seminal step in identifying key pathways and molecules
involved in kidney cancer so that specific therapies that target these
new genes can be developed to treat this cancer.»
Because so few
genes are
involved, the
new test will be cheaper and faster, while remaining accurate, they said.
The
new locus they have identified is near a cluster of
genes which code for proteins called «glycophorins» that are
involved in the malaria parasite's invasion of red blood cells.
Today theories of links between genetics and behavior have led to what Rafter calls ««
new» or «liberal» eugenics» that
involves the elimination of «bad»
genes by choice, such as the abortion of fetuses that test positive for mental retardation.
Susanne Foitzik, an evolutionary biologist at Johannes Gutenberg University Mainz in Germany who was not
involved in the
new research, has discovered a few candidate
genes in another slavemaking group of ants — the Myrmicinae subfamily.
The researchers used their
new method to identify a number of previously unknown
genes that are
involved in B - cell development.
«Given the similarities in the molecules and the mechanisms
involved in limb development in vertebrates and invertebrates, the fly is a very useful genetic model in which to identify
new genes that potentially participate in limb development in vertebrates and their possible association with congenital diseases,» says Ana Ferreira, who has participated in the study.
The
new study also pins down the role of a
gene that researchers knew was somehow
involved in cellulose production in bacteria, but weren't sure how.
The authors conclude that the study of marine mammals is just the first demonstration of this
new evolutionary approach, and is versatile enough to be applied to many other emerging questions concerning key
genes involved in the diversity of life.
«There undoubtedly are many more
genes involved in these pathways and these will need to be sorted out,» says Joel Cracraft, an evolutionary biologist at the American Museum of Natural History in
New York City.
Professor Peter Kraft at Harvard TH Chan School of Public Health, USA, says: «Given the size of these studies, we expected that we would find a lot of
new breast cancer risk variants, but the studies tells us a lot more about which
genes are
involved, revealing many previously unsuspected
genes and genetic mechanisms underlying breast carcinogenesis.
Prof Andrés Cervantes, Biomedical Research Institute, INCLIVA, University of Valencia, Spain, ESMO spokesperson, not
involved in the study, commented: «This is a
new understanding of how to treat a select group of patients that are wild - type for the KRAS, NRAS, BRAF and PIK3CA
genes who can be treated with the same anti-EGFR antibody and a change in chemotherapy following progression.
By identifying novel
genes and molecular pathways
involved in shaping a taste cell's function, these findings may someday allow scientists to treat taste disorders, characterize
new taste qualities, or even fine - tune a person's taste perception to encourage healthier eating.
Using a
new technique that accounts for how
genes interact, Italian researchers have identified
new networks of related
genes that may be
involved in ASD — including
genes that are related to cancer.
For the manatee, walrus, dolphin, and killer whale, the return to the sea
involved many evolutionary trade - offs amongst hundreds of
genes: a general loss of the number of sensory
genes for smell and taste,
new functions for
genes forming skin and connective tissue, and
genes involved in muscle structure and metabolism.
With chronically infected mice as their model, the researchers used a
new technology called ATAC - seq to map the regulatory regions of the genome — the sections of DNA
involved in switching
genes on and off — in the animals» exhausted and functional CD8 + T cells.
Gene drive is so different from other technologies
involving genetic modification that it requires a whole
new way of thinking about how to evaluate and regulate it, says Jennifer Kuzma, a natural and social scientist at North Carolina State University (NCSU) in Raleigh who helped organize a February workshop there.
To begin to grapple with those questions, the researchers
involved in the
new study first selected as «seeds» the nine
genes that have been most strongly tied to ASDs in recent sequencing research from their labs and others.
The researchers tested whether HDACis, which promote long - lasting activation of
genes involved in learning and memory, could help replace old traumatic memories with
new memories.
Three simultaneous reports
involving more than 32,000 participants uncovered four
new diabetes - associated
gene variants, bringing to 10 the number of known non-Mendelian genetic risk factors for type 2 diabetes.
The findings are the first to tie together the roles of
genes and beneficial microbes in the inflammatory bowel disease, says biologist Brett Finlay of the University of British Columbia in Vancouver, who was not
involved in the
new work.
In the
new study
involving mice, published in the journal Molecular Neurodegeneration, the injection of zinc finger repressed the mutant copies of the
gene for at least six months.
A
new examination of the dolphin genome identifies
genes involved in the evolution of large brains.
It's basically a single amino - acid change in a particular
gene, although
newer varieties are getting a bit fancier and multiple
genes may be
involved.
Additionally, in demonstrating the usefulness of the
new method, the discovery paves the way for faster progress toward identifying
genes involved in complex mental illnesses such as autism and schizophrenia — as well as potential drugs for such conditions.
The
new method
involves isolating small sections of thousands of
genes in tiny droplets of water suspended in an oil.
After conducting studies in both humans and mice, the researchers said this
new schizophrenia risk
gene, called C4, appears to be
involved in eliminating the connections between neurons — a process called «synaptic pruning,» which, in humans, happens naturally in the teen years.
These include Cenix Bioscience, which has developed a
new lab technique to identify the
genes that are
involved in cell division, predicted to be very useful for finding potential
new targets for anticancer drugs.