Sentences with phrase «new genomic approaches»

Dr. Funari's scientific career spans two decades developing or encompassing new genomic approaches to unfold new mysteries of human genetic diseases.

Not exact matches

But it has been disappointing in that the kind of genetic variation it detects has turned out to explain surprisingly little of the genetic links to most diseases... One issue of debate among researchers is whether, despite the prospect of diminishing returns, to continue with the genomewide studies, which cost many millions of dollars apiece, or switch to a new approach like decoding the entire genomes of individual patients.The unexpected impasse also affects companies that offer personal genomic information and that had assumed they could inform customers of their genetic risk for common diseases, based on researchers» discoveries...

Traditional genetic approaches together with the new wealth of genomic information for both human and model organisms open up strategies by which drugs can be profiled for their ability to selectively kill cells in a molecular context that matches those found in tumors.

Since the completion of the Human Genome Project in 2003, scientists have expanded their knowledge of how living cells work with new approaches including genomics, proteomics, and systems biology.

But now «the approach can be reset using the bacterial and human genomic data,» says immunologist Steven Schutzer of the University of Medicine and Dentistry of New Jersey.

The advances in genotyping and functional genomics open new approaches to environmental science, including public health issues

The move comes in response to the announcement earlier this week of a new U.S. company, launched by sequencing - machine manufacturer Perkin - Elmer and J. Craig Venter of The Institute for Genomic Research, that plans a brute - force approach to sequencing the human genome within 3 years (ScienceNOW, 12 May).

Exomes and the Clinical Research Conundrum: New Approaches to Enhancing the Value of Genomic Data

Identifying how genomic islands move and their effect on bacterial physiology could lead to new approaches to bypass bacterial defenses, Hudson said.

It is widely known that genomics has already begun to influence medicine and that bioinformatics holds the key for developing new medical approaches, but how does medical genomics really work?

«New approaches in medical genomics: A step forward in Parkinson's disease.»

To overcome the extreme genomic complexity, the team used new long - read sequencing technology that boosted the quality of the genome sequence obtained by more than one hundred fold over standard short - read approaches.

In a study of 124 patients with advanced breast, lung, and prostate cancers, a new, high - intensity genomic sequencing approach detected circulating tumor DNA at a high rate.

A new method by researchers from New England Biolabs and New Mexico State University provides plant biologists with a quick and simple approach for separating plant nuclear DNA from organellar DNA for genomic and metagenomic studinew method by researchers from New England Biolabs and New Mexico State University provides plant biologists with a quick and simple approach for separating plant nuclear DNA from organellar DNA for genomic and metagenomic studiNew England Biolabs and New Mexico State University provides plant biologists with a quick and simple approach for separating plant nuclear DNA from organellar DNA for genomic and metagenomic studiNew Mexico State University provides plant biologists with a quick and simple approach for separating plant nuclear DNA from organellar DNA for genomic and metagenomic studies.

«We're confident that applying this same approach to a lot of new data will help us discover additional genomic variations and identify specific genes that play a role in schizophrenia and other psychiatric conditions.»

Interestingly, genomic analyses suggested that ESCC and head and neck squamous cell carcinoma (HNSCC) shared some common pathogenic mechanisms, and ESCC development is associated with alcohol drinking.These findings would provide a brand - new insight into the understandings of ESCC tumorigenesis, and would help clinicians to develop more effective diagnostic and therapeutic approaches for ESCC.

-- In silico basic and systems biology: We develop innovative approaches to reverse engineer biological networks from omics data, model tumor progression at the genomic, transcriptomic and epigenetic level, automatically annotate new proteins and functional elements through integration of complex and heterogeneous data, including data obtained from high - throughput sequencing or time - lapse video - microscopy.

Vinetz said the next step will be to begin exploiting the genomic information «for vaccine and diagnostics development, experimental approaches to understanding mechanisms of disease pathogenesis and how Leptospira persist in the environment, all critical for developing new public health interventions aimed at reducing the global impact of this important but neglected zoonotic disease.»

Identification of new pathological biomarkers for monogenic diseases using a functional genomic approach.

Currently, we are exploring several environmental samples retrieved from allover the world - ranging from hydrothermal vents in Japan to hot springs in Yellowstone National Park and New Zealand — for the presence of novel archaeal (and bacterial) lineages using cultivation - independent approaches, such as metagenomics and single cell genomics.

Disa will work on the genomic exploration of «microbial dark matter», focusing on new archaeal lineages and viruses, using both lab - and bioionformatics - based approaches.

The study, integration and analysis of these data increasingly allows to unravel the genetic mechanisms and networks underlying complex biological phenotypes paving the way for an era of «genomic medicine,» in which new diagnostic and therapeutic approaches to common multifactorial conditions are emerging.

«Our goal is to use comparative genomics approaches to fill in gaps in our understanding of how plant reproduction works and to define the aspects of the mechanisms we've discovered so far that are either ancient or new innovations.»

The Functional Genomic and Computational Assessment of Threats (Fun GCAT) program challenges research teams to develop new approaches for screening genetic information for evidence of a potential biological threat.

Information gained from this work will serve to enhance the clinical usefulness of findings from genomic sequencing (for example, next - generation sequencing or comprehensive genomic profiling), determine therapeutic approaches based on genomic findings, aid in the development of clinical trials and related options, and provide supportive rationale for exploring new therapies.

These approaches are important complements to empirical studies, generating new predictions that we can test with genomic data or in field or greenhouse experiments.

Ultimately, integrating the vast datasets generated by these different atlases may prove the greatest challenge of all — but, the researchers hope, it will also be the most rewarding, combining structural, genomic and epigenetic approaches under the umbrella of a new kind of cartographic exploration.

MELGEN will explore emergent new techniques, for example the Sanger Institute (GRL) and ServiceXS will explore new approaches to genomic data generation from such samples and from fresh tumour and, critically, with other participant groups develop new statistical / bioinformatic approaches to data analysis.

The branch serves as a focal point at the NIH campus for the analysis of a wide variety of large - scale genomic data generated in the course of laboratory and clinical studies, with branch members actively involved in efforts aimed at developing new bioinformatic approaches for the analysis and visualization of these data.

Liaison between clinical and basic sciences can be utilized to achieve this, including maximizing the potential of genomic data to tailor individualized treatments, collecting natural history information to identify disorder - specific management requirements, developing new therapeutic approaches through improved knowledge of molecular pathways and protein network interactions, and testing potential new drugs via well - conducted clinical trials.

Here, we discuss and illustrate the strengths and weaknesses of approaches for the annotation and classification of important elements of protein - coding genes, other genomic elements such as pseudogenes and the non-coding genome, comparative - genomic approaches for inferring gene function, and new technologies for aiding genome annotation, as a practical guide for clinicians when considering pathogenic sequence variation.

Our approach blends new genomic technologies with established ecological principles.

Jesse Ausubel served on the Task Force, whose report explores new genomic, acoustic, and optical approaches, and their synergies, especially in relation to the deep ocean, and some organizational strategies to speed progress.