Sentences with phrase «new granule cell»

When a new granule cell neuron is made in the dentate gyrus, it needs to get «wired in,» by forming synapses, or connections, in order to contribute to circuit function.

Overstreet - Wadiche and UAB colleagues posed a basic question: Since the number of neurons in the dentate gyrus increases by neurogenesis while the number of neurons in the cortex remains the same, does the brain create additional synapses from the cortical neurons to the new granule cells, or do some cortical neurons transfer their connections from mature granule cells to the new granule cells?

Their answer, garnered through a series of electrophysiology, dendritic spine density and immunohistochemistry experiments with mice that were genetically altered to produce either more new neurons or kill off newborn neurons, supports the second model — some of the cortical neurons transfer their connections from mature granule cells to the new granule cells.

Not exact matches

«This work suggests that activating autophagy to help rid cells of stress granules offers a new approach to neurodegenerative disease treatment,» Taylor said.