Labs that derive
new human embryonic stem cell lines are few, partly because they can not get financial support from federal sources.
The new NIH guidelines do not permit the use of federal funds for creating
new human embryonic stem cell lines.
What Collins does not say, however, is that the new NIH guidelines also allow for federal funds to be used in studying
new human embryonic stem cell lines that are created (by private entities, of course) beyond the 700 currently in existence.
The claim echoes those made many times in the emotional debate over federal funding of
new human embryonic work.
In May 2005, Hwang and his colleagues reported that it had produced 11
new human embryonic stem (ES) cell lines that carried the genetic signature of patients with diabetes, spinal cord injury, or a genetic blood disorder (Science, 20 May, p. 1096).
Not exact matches
Benedict argued that non-conjugal reproduction such as in vitro fertilization had created «
new problems» ¯ the freezing of
human embryos, for instance, and the selective abortion of medically implanted embryos, together with pre-implantation diagnosis,
embryonic stem - cell research, and attempts at
human cloning.
Scientists looking for
new methods to make
human tissue have successfully used cloning technology to create
embryonic stem cells from skin cells.
Just before Thanksgiving, news broke about a
new stem - cell technique that could produce the equivalent of
embryonic stem cells (ESCs) but without using or destroying
human embryos.
The increasing use of in - vitro - fertilisation techniques, and the emergence of
new possibilities involving
human cloning, mixing of
human and animal genetic elements, and the use of
embryonic stem cells for research, among other things, brought the need for further teaching.
The first page of Larsen's
Human Embryology states that, `... [W] e begin our description of the developing human with the formation and differentiation of the male and female sex cells or gametes [sperm and egg], which will unite at fertilisation to initiate the embryonic development of a new individual&ra
Human Embryology states that, `... [W] e begin our description of the developing
human with the formation and differentiation of the male and female sex cells or gametes [sperm and egg], which will unite at fertilisation to initiate the embryonic development of a new individual&ra
human with the formation and differentiation of the male and female sex cells or gametes [sperm and egg], which will unite at fertilisation to initiate the
embryonic development of a
new individual».
The
new strategy is based on
human RNA - binding proteins that normally help guide
embryonic development.
Now, many research advocates are wondering how Price's mix of views might play out in the
new administration's approach to a wide range of issues, including funding, research involving
human embryonic stem cells and fetal tissue, and the appointment of a
new NIH director.
The laboratory process, described in the journal Scientific Reports, entails genetically modifying a line of
human embryonic stem cells to become fluorescent upon their differentiation to retinal ganglion cells, and then using that cell line for development of
new differentiation methods and characterization of the resulting cells.
TOKYO — Research involving
human embryonic stem (ES) cells will become easier in Japan as a result of
new ethical review requirements that take effect today.
- Our results provide
new insights into the mechanisms of how POLR3G gene regulates stem cell state, which in turn sheds light on the complex mechanisms with which
human embryonic stem cells both self - renew and maintain the ability to differentiate.
Researchers from Turku, Finland, have discovered
new information about the mechanisms which maintain gene activity in
human embryonic stem cells.
Salk scientists and colleagues have proposed
new molecular criteria for judging just how close any line of laboratory - generated stem cells comes to mimicking
embryonic cells seen in the very earliest stages of
human development, known as naïve stem cells.
One is using cells derived from
human embryonic stem cells to treat spinal cord injury (although funding problems have stopped the trial enrolling
new patients) and another is testing a treatment for age - related macular degeneration.
A
new paper in the journal Cell claiming to have achieved breakthrough stem cell work — using cloning to create personalized
human embryonic stem cells — is coming under serious scrutiny.
A bill that would allow federal funding for derivation of
new lines of
human embryonic stem (ES) cells passed the U.S. House of Representatives yesterday 238 to 194 after more than four hours of debate.
Research involving
human embryonic stem cells will become easier in Japan as a result of
new ethical review requirements that took effect 21 August.
According to a
new analysis, the cell line they created represented the first example of parthenogenetic
human embryonic stem (ES) cells.
Benedict argued that non-conjugal reproduction such as in vitro fertilization had created «
new problems» ¯ the freezing of
human embryos, for instance, and the selective abortion of medically implanted embryos, together with pre-implantation diagnosis,
embryonic stem - cell research, and attempts at
human cloning.
Human Embryonic Stem (hES) cells derived from Preimplantation Genetic Diagnosed (PGD)- embryos offer a
new alternative source of cellular model as they can be largely expanded, differentiated in several cell types and harbors «naturally» the causative mutation of the pathology.
At the International Society for Stem Cell Research 2017 Annual Meeting (June 14 - 17, 2017; Boston, USA), Asterias Biotherapeutics, Inc (CA, USA) will present
new 9 - month efficacy and safety data from their ongoing SCiStar Phase I / IIa trial of
human embryonic stem cell - derived oligodendrocyte progenitor cells.
For the first time since the linkurl: National Institutes of Health; http://www.nih.gov/ released its
new guidelines for the derivation of
human embryonic stem cell (hESC) lines last summer, a line approved under the Bush administration has been recommended for inclusion into the growing federal registry of lines eligible for federal funding.
Using pre-implantation genetic diagnosis derived
human embryonic stem cell lines (hES) or
human induced pluripotent stem cells carrying the causal mutation for neuro - muscular diseases, our objective is double: identify
new physiopathogical mechanisms and develop
new therapeutic strategies.
Human embryonic stem cellsImage: Wikimedia commons, Nissim Benvenistylinkurl: Advanced Cell Technology; http://www.advancedcell.com/ (ACT) filed an Investigational
New Drug (IND) application yesterday (November 18) to conduct a phase I / II trial using hESCs to treat a genetic eye disease.
Researchers have developed a
new technique for creating
human embryonic stem cells by fusing adult somatic cells with
embryonic stem cells.
Since
human embryonic stem cells grow in an adherent culture system, for cells being reprogrammed this «
new culture system» is an adherent culture system (to try and mimic the conditions the
embryonic stem cells want to be happy).
According to
new research led by scientists at The Salk Institute, the vitamin plays a critical role in helping to guide the
embryonic heart to its final destination in the left side of the body of all vertebrates, including
humans.
With the
new SIF - seq technique, mouse
embryonic stem cells can be used to identify
human embryonic stem cell enhancers even when the
human enhancers are not present in the mouse genome.
This question might sound familiar, because it was central to the 2001 debate over
human embryonic stem cells — a debate that was, back in the months before the 9/11 attacks, considered a significant controversy for George W. Bush's
new administration.
For more on
human embryonic stem cells, see Teisha Rowland's «All Things Stem Cell post on «Induced Pluripotent Stem Cells: A
New Stem Cell Line with a Long History,» The National Institute of Health's Stem Cell FAQs, or, for a visual explanation of terms used, see All Things Stem Cell's Visual Stem Cell Glossary.
A
new study confirms a seemingly obvious assumption about
human embryonic stem cell research: Countries with fewer restrictions on research outperform countries with more restrictions.
In the
new study, 12 patients will be treated with healthy scavenger cells, created in a laboratory from
human embryonic stem cells.
The Society believes that research involving the transfer of a
human nucleus into an animal egg will lead to important
new knowledge about cell nuclear replacement (CNR) technology and, if it were to prove possible to produce
embryonic stem cells by this route, would increase understanding of how to programme these cells to develop into different tissue types.
However, some consider
human embryonic stem cell research controversial because, in some cases, the
new stem cell lines are derived frozen
human embryos that have been donated for research.
Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of
human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation,
human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay,
New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of
New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters
A
new regulatory notice published this week proposes a rules adjustment that would slightly expand the definition of
human embryonic stem cells eligible for use in federally funded research.
Coinciding with CIRM's goals, three of the floors planned for renovation will accommodate the collaborative work of top stem cell researcher and UCSB professor James Thompson, who was the first to isolate
human embryonic cells in 1998; the
new Mellichamp and Ruth Garland Chairs of bioengineering and molecular mechanisms, respectively; and the «Deep Sequencing Core,» which will house, among other things, a device that will help develop
new genetic approaches to important cell biology inquiries.