«Even with
the new immunological studies, we can't tell what's special about the whole - cell vaccine that makes it better,» says Kathryn Edwards, the director of the Vanderbilt University School of Medicine Vaccine Research Center.
Not exact matches
According to a
new study, these babies face a greater risk of developing
immunological disorders compared to children born naturally.
In the
new study, scientists built upon previous discoveries that a safe, non-reproducing vaccine strain of T. gondii could cure mice of several types of solid tumors, and identified which parasite proteins and which
immunological pathways are required to break immune tolerance.
Furthermore, this
study also encourages the application of iPSC - MSCs as an exciting
new therapeutic option for a range of
immunological disorders and suggests that further
study of the secreted factors may allow the construction of efficient cell - free therapies in the near future.
Therefore the group: i) characterizes the specificity of these antibody responses to identify relevant targets for a vaccine; ii) developes
new approaches to test antibody responses; and iii) adoptes the
immunological analysis in preclinical (in rabbits and macaques) and clinical vaccines
studies to identify predictive signatures for the development and prioritization of
new HIV - 1 vaccine candidates.