His work centers on
new immunomodulatory agents and formulations, as well as the process development necessary to take vaccines and therapeutic candidates from the lab to the clinic.
The new immunomodulatory mechanism uncovered employing an in vivo mouse model suggests that iPSC - MSCs secreted immunomodulatory factors inhibit the cleavage of caspases and suppress T cell responses to promote an anti-inflammatory environment.
Not exact matches
Ultimately, the researchers» goal is to use these
new findings to improve the effectiveness of
immunomodulatory treatments.
This
new study suggests that iPSC - MSC - secreted factors modulate T cell responses by inhibiting the cleavage of caspases, in what represents a novel
immunomodulatory mechanism [3].
New research demonstrates how proinflammatory stimuli can promote the production of extracellular vesicles from MSCs with enhanced
immunomodulatory capacity.
Ghosal, S., et al. «
Immunomodulatory and CNS effects of sitoindosides IX and X, two
new glycowithanolides from Withania somnifera,» Phytother Res, 3 (5): 201 - 6, 1989.