Sentences with phrase «new lead compounds»

Taken together, the results show that AAPs are exceptionally promising new lead compounds for anti-TB drug development.

Not exact matches

The Washington Post reported that new, high - tech scanners search for organic compounds in explosives, which sometimes leads to false alarms when scanning food items.

In Northern Ireland, the election compounds the political turmoil, which followed the failure of the DUP - led power - sharing government, electoral losses for the DUP, and the subsequent inability of the unionist and nationalist parties to come to a new agreement.

A team led by Stuart Licht at the Technion - Israel Institute of Technology in Haifa has come up with a new cathode made from unusual iron - based molecules — iron (VI), or «super-iron,» compounds — that absorb more electrons than manganese dioxide.

The objective of the research project led by Marko Kallio, Principal Scientist at VTT, was to accelerate the drug development process by identifying new compounds that would possess similar binding properties and cellular phenotype, but a different chemical structure, as the selected drugs in clinical use or investigational compounds in development.

Drug - resistant bacteria are thwarting the world's last - resort antibiotics, leading scientists to seek new compounds from poisonous frogs, backyard soil bacteria, and other wildlife.

«Our computer aided drug screening process has now identified two new classes of anti-cancer agents, specifically targeting two distinct and novel mechanisms underpinning cancer,» said Dr Andrea Brancale from Cardiff University's School of Pharmacy, who led on the compound's design.

Two years ago the pharmaceutical giant GlaxoSmithKline purchased Sirtris for $ 720 million, and by August of last year The New York Times was speculating that compounds capable of activating sirtuin genes were now the leading candidates for what the newspaper called «the ultimate free lunch... a drug that tricks the body into thinking it is on [a calorie - restricted] diet.»

Leading the pack is a compound called tasocitinib, made by the New York - based pharmaceutical giant Pfizer.

An MIT - led research team has now found that it can reverse this age - related endurance loss in mice by treating them with a compound that promotes new blood vessel growth.

Although the process of developing the new compounds into clinical drugs is complex and lengthy, Professor Kirk is optimistic the findings will lead to new treatments.

The researchers, led by Sara Jaeger, Jeremy McRae, and Richard Newcomb of Plant and Food Research in New Zealand, found that for four of the ten odors tested, there was indeed a genetic association, suggesting that differences in the genetic make - up determine whether a person can or can not smell these compounds.

These «new» compounds could lead to new medicines and drugs.

Instead of simply joining two words together by deleting a space, the individual words that are joined together in compound DNA words are altered, leading to a large number of completely new words.

Some of these changes can lead to the formation of new compounds that are potentially toxic.

«We've seen hints before that PAK4 and PI3K pathway are linked, but finding evidence of their interaction is an important advance because it gives us additional avenues to explore in testing promising new inhibitor compounds that can tackle this disease,» says Dr Claire Wells, who led the study.

CREATIVE CHEMISTRY Sarah Reisman spends her days thinking about innovative ways to build complicated chemical compounds that could lead to new drugs for numerous ills.

«New compound for slowing aging process can lead to treatments for brain diseases.»

For example, creative problem - solving AI could someday make snap decisions that save the lives of the passengers in a self - driving car if its sensors fail, or propose unconventional combinations of chemical compounds that lead to new drugs for previously untreatable diseases.

«The core is mostly iron and some nickel, but also contains about 10 % of light alloys such as silicon, oxygen, sulfur, carbon, hydrogen, and other compounds,» Hirose, lead author of the new study to be published in the journal Nature.

In the new study, led by Purdue biochemist Natalia Dudareva, the team looked for genetic changes as the plant developed from its budding stage, which had the lowest levels of volatile organic compounds, to its flower - opening stage, with the highest levels.

That concern is one reason the research team, led by Christina Smolke, a synthetic biologist at Stanford University in Palo Alto, California, stopped short of making a yeast strain with the complete morphine pathway; medicinal drug makers also primarily use thebaine to make new compounds.

If the compound identified in this study successfully reduces tissue death and improves recovery in further experiments, it could lead to new approaches for preserving brain cells after an ischemic stroke,» said Francesca Bosetti, Ph.D., Pharm.D., program director at the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

The chemists, led by Ian Henderson and Michael Ohlmeyer of Pharmacopeia, a company in Princeton, New Jersey, were able to prepare over 6000 different compounds using just a few simple reactions.

The need for new drug compounds that can combat skeletal dysplasia has led the Noriyuki Tsumaki group at CiRA, Kyoto University, to consider iPS cell technology.

Mikael Ehn has been working on this study over four years and is glad that the international cooperation in the large team has made it possible not only to detect these new compounds but also to explain the mechanism that leads to the formation.

As crude oil burns it releases many toxic chemicals, including lead, carbon monoxide, polycyclic aromatic hydrocarbons and volatile organic compounds, says Bin Jalaludin at the University of New South Wales in Australia.

Calling their compound a new therapeutic candidate for people with severe asthma and other chronic airway diseases, researchers say with additional research and development their discovery could lead to future clinical trials for asthma, Cystic Fibrosis and Chronic Obstructive Pulmonary Disease (COPD).

Although a 3 percent gain per year might not sound like much, the magic of compounding means that this pace of growth would lead to a doubling in the rate of new cases of type 1 diabetes in 23 years.

A new $ 4.1 million grant from the National Institute of Allergy and Infectious Diseases supports research to find compounds that block the growth of Ebola virus, which could lead to new antiviral drugs.

In order to explore new pharmacophore moieties, FC131 was used as a lead compound for the development of novel CXCR4 antagonists.

Navire Pharma's lead compounds were discovered and developed by the IACS team led by Phil Jones, Ph.D., executive director and head of drug discovery at IACS, together with Benjamin G. Neel, M.D., Ph.D., director of the Laura and Isaac Perlmutter Cancer Center at New York University (NYU).

His research utilizes molecular biology, cell culture, and animal models to study your body's cannabinoid system in an attempt to further our understanding of Cannabis as a medicine, and possibly lead to the development of new drug compounds.»

Lindsley, who also is professor of Pharmacology, Biochemistry and Chemistry in the medical school and College of Arts and Science, has helped pioneer development of drug - like compounds that, by adjusting the activity of receptors in the brain, may lead to new treatments for a wide range of brain disorders.

Coupled with a new gene - signature approach, this research project could identify compounds that will ultimately lead to the discovery of new neuropsychiatric drugs.

Their goal is to identify the compounds that could lower levels of the protein tau in the brain, which is considered one of the most promising approaches in Alzheimer's research and could potentially lead to new drugs to treat the disease.

The new material, made of a compound called barium stannate, could lead to the creation of smaller, faster, and more powerful electronics, and more efficient solar cells.

A new study finds a possible explanation for why lonely people often have poorer health outcomes: Loneliness triggers the «fight or flight» response, leading to higher levels of inflammation and lower levels of antiviral compounds.

Recent findings, the exhaustive listing of bioactive compounds found in whole - grain wheat, their content in whole - grain, bran and germ fractions and their estimated bioavailability, have led to new hypotheses.

Purefoy and Williams are fine actors but never really click as a duo, and as soon as the three leads arrive at the sketchy compound of Trudy's hippie - like new boyfriend, things grind to a halt regularly.

In tandem with twenty - inch Dunlop SP Sport Maxx tires with stiffer sidewalls and a new compound, the added compliance translates into more grip and confidence by better pinning the tires to undulating pavement — as experienced on the «Ring, one reason that it's the world's leading gauntlet for handling development.

The new standards would reduce the volatile organic compounds and nitrogen oxides that lead to smog by 80 %, reduce particulate matter by 70 % and reduce fuel vapor emissions almost entirely.

Elisabeth Bouwman at Leiden University, who led the team that discovered the catalyst, said the selectivity of the new compound is «completely unexpected».

The ingredients were not effective until they were all brought together properly — leading the researchers to ponder whether the ingredients work in synergy or if they in fact create new compounds.

As lead compounds have advantageous properties (which are often unpredictable based on their structure), a later filing directed specifically towards the lead compound (or a narrowly defined family of compounds) can be held as new and inventive.