Niyogi worked on identifying tryptophan biosynthesis pathways in Arabidopsis, which at the time was a relatively
new model organism.
«
A new model organism for aging research: The short - lived African killifish.»
The research opens the possibility of
a new model organism for human heart health and the distant prospect of incorporating such a gene into humans.
So he went in search of
a new model organism.
Years later, as I was wrapping up my Ph.D. after having spent countless hours centrifuging yeast, I couldn't wait to work with
a new model organism.
Not exact matches
New models suggest groups of humans evolve following some universal rules, and not unlike how
organisms evolve.
Traditional genetic approaches together with the
new wealth of genomic information for both human and
model organisms open up strategies by which drugs can be profiled for their ability to selectively kill cells in a molecular context that matches those found in tumors.
New techniques bring opportunities and challenges to
model organisms.
«It's always been hard to work with a
new organism,» says Jarvis, «CRISPR is awesome because suddenly, you don't have to spend decades developing a
model.»
The
new modeling tool — Carbon,
Organisms, Rhizosphere and Protection in the Soil Environment, or CORPSE — represents a major advance in the ability of scientists to simulate the global carbon cycle.
Using the
model organism, Caenorhabditis elegans, the researchers identified over 400
new mRNA editing sites — the majority regulated by ADR - 1 — and declared the protein the first global regulator of RNA editing.
The team
modelled how the membrane changed, enabling LUCA's descendants to move to
new, more challenging environments and evolve into two distinct types of single - celled
organism, bacteria and archaea, creating the deepest branch of the tree of life.
In experiments on the fruit fly
model organism Drosophila melanogaster, Heidelberg University biologists gained
new insight into how feeding behaviour is encoded and controlled.
Using a novel method they developed to map chromosome breaks in a
model organism, the budding yeast, Wenyi Feng, Ph.D., of Upstate Medical University and her colleagues have discovered
new information as to how and where chromosome fragile sites can occur in human DNA.
In the
new study, Lee and his colleagues studied piRNAs produced by cells in the reproductive system of the nematode worm, C. elegans, a classic
model organism studied by scientists to understand basic biological processes.
«By means of basic research on
model organisms, we are trying to understand human genome instability to identify elements, which, in the future, might be able to be explored as targets of
new anti-tumour medicines,» explains the researcher responsible for the project and director of Cabimer, Andrés Aguilera.
Given the rapid succession of generations in yeast, we can use it as a
model organism — and study the mechanisms of aneuploidy in much greater detail to find out whether we can derive from it
new approaches for diagnosing and treating human diseases.»
This approach opens
new avenues for research into memory using zebrafish as
model organism,» concludes Dr. Okamoto.
A
new study from the University of Michigan Life Sciences Institute now reveals how some of that cross-talk between tissues occurs in a common
model organism.
Collins used a
new analysis performed by NIH staff to address concerns expressed by many of the
model organism researchers gathered at TAGC, particularly a 2015 analysis by Michael Wangler, Keith Yamamoto, and Hugo Bellen that suggested NIH grant support for Drosophila research is declining.
Dubbed
model -
organism ENCODE (modENCODE), this
new focus will apply innovative methods and technologies for the study of gene regulation to the smaller, and therefore more manageable, genomes of the fruit fly (Drosophila melanogaster) and the round worm (Caenorhabditis elegans).
As our role in the HapMap concluded, we took on a
new grant: constructing the genetic map of C. briggsae, a small roundworm similar to the well - known
model organism, C. elegans.
She added, «
New model systems will be a magnet for people from outside the field of marine microbial ecology as they will suddenly be able to work with marine microbes in ways that they are used to working with other
model organisms.»
The Microbiology Services Division at Porton Down, part of the National Infection Service directorate, has extensive high - containment laboratory facilities and rare capabilities to handle infectious
organisms under the highest levels of containment, and the ability to work with in vivo
models to evaluate
new therapeutic interventions against these
organisms.
In a
new study, published in Current Biology this week, a research team from Uppsala University reports
new insights into the regenerative capabilities of Stentor, a single celled
model organism for regeneration biology.
Furthermore,
new genome - editing technologies such as CRISPR / Cas9 now enable the efficient derivation of precision disease
models incorporating patient - specific genetic variants as a means of recapitulating essential aspects of human disease in mouse and other
model organisms.
Today, analyzing and editing genomes, proteomes and metabolomes has become a standard for many
model systems; imaging beyond the diffraction limit of light and
new technologies for studying protein structures provide insights deeper than ever before; the characterization of large populations of cells or
organisms brings unprecedented statistical power; and studying nearly all
organisms of an ecosystems as a whole allows generating comprehensive
models.
Identifying a full list of imprinted genes for humans and
model organisms will give scientists a springboard to characterize the mechanisms and functions of imprinting, says Ian Morison of the University of Otago in Dunedin,
New Zealand.
In addition, projects to perform genetic interaction screens on disease genes in
model organisms (yeast, worm, fly, fish) will not be considered, unless the project includes substantive specific aims that investigate the disease relevance of any
new genes discovered in human or mammalian
model systems.
This network funds pilot studies to expedite collaboration between the two groups, conduct
model organism - based functional studies of disease gene variants, and develop
new therapeutic strategies using
model organisms.
New approaches to microscopy, precision laser ablation of individual cells and capillaries, and genetic engineering of model organisms are opening new vistas for exploring the brain and how it wor
New approaches to microscopy, precision laser ablation of individual cells and capillaries, and genetic engineering of
model organisms are opening
new vistas for exploring the brain and how it wor
new vistas for exploring the brain and how it works.
A specific focus will be put on novel
model organisms or clades that are now amenable to analysis thanks to
new methodologies.