Sentences with phrase «new models for human diseases»
These mice will be preserved in repositories and made available to the scientific community representing a valuable resource for basic scientific research as well as generating new models for human diseases.
https://www.infrafrontier.eu/ Not exact matches
Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.
More recently, researchers have induced stem cells from diseased human somatic cells, which may serve as new model systems for various illnesses.
«New gene editing technique turns human pluripotent stem cells into a model system for polycystic kidney disease.»
These observations and others have convinced the researchers that their CRISPR / Cas9 and hPSC system produces a stable, biologically accurate human model for a common genetic disease where new understanding and new therapies are desperately needed.
«Finches offer researchers a new tool with which to study Huntington's disease: Like humans, songbirds learn their vocalizations, suggesting they could be useful as models for certain disorders.»
«Investigators create complex kidney structures from human stem cells derived from adults: New technique offers model for studying disease, progress toward cell therapy.»
Because of the similarities in ocular anatomy, canine models contribute significantly to the understanding of retinal disease mechanisms and the development of new therapies for human patients.
This research is all aimed at tissue repair strategies, but it also may provide new in vitro models for human disease.
The researchers hope their new cell lines will be a useful resource for studying the cellular and molecular intricacies of Huntington's further, and suggest they may provide a model for examining other diseases of the brain that are specific to humans.
Given the rapid succession of generations in yeast, we can use it as a model organism — and study the mechanisms of aneuploidy in much greater detail to find out whether we can derive from it new approaches for diagnosing and treating human diseases.»
An important model in studying human disease, the non-coding RNA of the canine genome is an essential starting point for evolutionary and biomedical studies, according to a new study led by The Genome Analysis Centre (TGAC).
Our finding of similarity in clinical progression between human patients and Huntington's disease monkeys suggests monkeys could become a preclinical, large animal model for the development of new treatments.»
The researchers» strategy — generating disease - specific nerve cells, identifying a causative gene for developmental defects, validating the gene - specific defect in animal models, and then investigating interactions with other genes both in animal models and in humans — represents a promising new approach for understanding the mechanisms underlying some of the most intractable psychiatric illnesses.
The pigs showed both movement problems and respiratory difficulties common to human patients, and it is hoped that this model will assist in the creation of new treatments for Huntington's — a genetically inherited and fatal disease which affects tens of thousands of people.
Since genetic loss of aP2 in mouse models and in humans results in lowered risk of cardiometabolic disease, the molecule offers an exciting opportunity for new intervention strategies.
With the reference cell census data in hand, the research team is excited to conduct additional studies, including ones involving models or human patients with gastrointestinal conditions — Crohn's disease, ulcerative colitis, gastrointestinal cancers, forms of food allergy, etc. — aimed at identifying changes in gene expression and epithelial structure and function that could reveal new insights and opportunities for therapeutic development.
«New therapies for ALS are urgently needed — and our creation of human models using iPS cell technology will hopefully deepen our understanding of how the disease develops — and lead to relevant therapies for patients,» said Senior Investigator Steve Finkbeiner, MD, PhD, who leads ALS research at Gladstone.
December 19, 2017 — Noteworthy NIH advances in basic research include a 3 - D model of human brain development and disease, a virus linked to food sensitivity, and a new role discovered for the thalamus.
To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new therapies in humans.
This innovative model allows the researchers to test viable new drugs for this disease, and it provides a potential solution to studying other human disorders of aging in mice.
«The development of a functional human kidney glomerulus chip opens up an entirely new experimental path to investigate kidney biology, carry out highly personalized modeling of kidney diseases and drug toxicities, and the stem cell - derived kidney podocytes we developed could even offer a new injectable cell therapy approach for regenerative medicine in patients with life - threatening glomerulopathies in the future,» said Ingber.
Robert D. Schreiber, Ph.D., an associate director of CRI's Scientific Advisory Council based at Washington University School of Medicine in Saint Louis, Missouri, developed a new model of breast cancer that more closely resembles the progression of hormone receptor - positive disease in humans, overcoming a major obstacle in the study of breast cancer and the development of new immune - based therapies for the disease.
These findings have identified an alternative source of replacement tissue for use in human retinal cellular therapies, and provide a new in vitro cellular model system in which to study RPE diseases affecting human patients.
Gage and Ghosh discuss how human skin cells induced to return to an immature state («induced pluripotent stem cells» or IPS cells) are revolutionizing our understanding and treatment of mental and neurodegenerative disorders, such as Parkinson's disease, as well as leading to new models of drug development for all diseases.
Because of the similarities in ocular anatomy, including the presence of a cone photoreceptor - rich central retinal region [10], [11], and the frequently similar genotype - phenotype correlation [1], canine retinal disease models contribute significantly to our understanding of retinal disease mechanisms and the development of new therapies for human patients [12]--[20].