Sentences with phrase «new preclinical models»

The goal of this Center of Excellence is to better define thrombus development in patients with cancer, test the efficacy of novel therapies, develop new preclinical models, and create and expand biorepositories to provide a valuable resource to researchers across Cleveland Clinic.

E. Intensify research on the major drivers of childhood cancers Improve our understanding of fusion oncoproteins in pediatric cancer and use new preclinical models to develop inhibitors that target them.

Not exact matches

In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS ONE from the Perelman School of Medicine at the University of Pennsylvania.

Complementing the company's in - house Crispr programme, the technology will identify and validate new targets in preclinical models across a range of disease areas.

With this new understanding of how Del - 1 can inhibit periodontal bone loss — both by reducing inflammation and by restraining the activity of osteoclasts that resorb bone tissue — the researchers tested it, in a preclinical model of periodontitis observing that Del - 1 significantly reduced inflammation and tissue damage and that there was significantly less bone loss.

In a paper published in Advanced Functional Materials, the research team reports on the new material's key properties, many of which can be finely tuned, and on the results of using the material in preclinical models of wound healing.

In a new advancement, they have developed a system in preclinical models that offers a finer degree of control — and, therefore, safety — in opening the barrier.

Long - awaited breakthroughs in developing preclinical animal models are signaling a new era for liver - targeted viruses and beyond

According to the authors of the study, in future researches it will be necessary to know about the action mechanism of the new products - highly selective and with low cell toxicity on in vitro tests - and broaden preclinical studies with laboratory animal models.

«Novel imaging model helps reveal new therapeutic target for pancreatic cancer: Antisense treatment in preclinical models shows effectiveness against deadly tumors.»

These findings are promising for developing a preclinical, large animal model of Huntington's disease for assessing new therapeutics, which could ultimately provide better treatment options, including altering the course of the disease.

Our finding of similarity in clinical progression between human patients and Huntington's disease monkeys suggests monkeys could become a preclinical, large animal model for the development of new treatments.»

Development of advanced preclinical models are needed to further elucidate the complex mechanisms underlying asthma exacerbation and investigate new therapeutic strategies.

Dr. Putoczki said the preclinical model would be very useful for testing new treatment options, such as immunotherapy.

PHILADELPHIA — In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich's ataxia (FA), a widely used cholesterol - lowering drug increased a precursor of HDL (high - density lipoprotein), the «good cholesterol,» according to new research published in PLOS One from the Perelman School of Medicine at the University of Pennsylvania.

Identification of new therapeutic applications for known drugs: Boston Children's investigators have developed and characterized a wide variety of preclinical assays and animal models useful for identifying additional therapeutic indications for safe compounds.

A new generation DNA - based vaccine against Zika virus showed protection from infection, brain damage and death in a preclinical model.

The Bancroft laboratory was funded by TBVAC2020 to provide preclinical animal models to evaluate new TB vaccine candidates.