It may take as long to breed
a new resistance gene into a new cultivar as to introduce a new fungicide (± 10 years), even though this time can be shortened somewhat today with molecular tools by reducing the back - crossing cycles.
When the first results confirmed that we had indeed found
a new resistance gene, I was really excited.»
It has therefore been generally assumed that wastewater treatment plants are the ideal location for pathogenic bacteria to develop
new resistance genes.
In addition to his basic science programs, Jones has isolated and is isolating
new resistance genes against potato late blight from wild relatives of potato, with the goal of using them to deliver market - favoured potato varieties that are protected from late blight by genes, rather than by chemistry.
Because disease organisms mutate quickly to overcome crop resistance controlled by single genes, researchers are rushing to identify
new resistance genes and to incorporate multiple genes into high - yielding varieties, according to Ravi Singh, CIMMYT wheat scientist who participated in the reported study.
Not exact matches
With respect to antibiotic
resistance, this novelty can be induced and we can trace the novelty to particular mutations arising absent
gene transfer; i.e. the
genes which give rise the
resistance were not present prior to the mutation, they are
new sequences and not simply the activation of dormant
genes.
New research suggests it may be possible to restore susceptibility to antibiotics in superbugs by locating and inactivating
genes that promote
resistance.
By adding these
new genes, genetic engineers hope the plant will express the traits associated with the
genes, such as
resistance to certain diseases or herbicides.
Mice trapped in
New York City apartment buildings harbored disease - causing bacteria and antibiotic
resistance genes.
Professor Bruce Fitt, professor of plant pathology at the University of Hertfordshire, added: «This
new understanding of plant defense through ETD suggests different operations of specific
resistance genes which will help us to be more successful in breeding
new strains of crops for
resistance.
Professor Dale said the correlation demonstrated between the RGA2
gene activity and TR4
resistance opened up
new research.
One of the
newest banes of U.S. medical centers, a supervirulent and multidrug - resistant strain of Acinetobacter baumannii, likewise appears to have picked up most of its
resistance in
gene swaps with other species.
Bacteria make up about one - third of the solid matter in human stool, and Scott Weber, of the State University of
New York at Buffalo, studies what happens to the antibiotic
resistance genes our nation flushes down its toilets.
But they also collected wild relatives of chickpeas in southeastern Turkey that hold «great promise,» von Wettberg says, as a source of
new genes for traits like drought -
resistance,
resistance to pod - boring beetles, and heat tolerance.
The
new method has been tested in greenhouse trials to show that the more copies of the
gene, the greater the
resistance to soybean cyst nematode.
Although the researchers suspected that having more copies of the
gene sequence might confer a greater degree of
resistance, they had no way of testing their suspicions before the
new assay was developed.
New research presented here yesterday at the annual meeting of the American Association for the Advancement of Science (which publishes ScienceNOW) finds that a
gene associated with increased risk of asthma is also linked to
resistance against a parasitic worm.
The number of copies of the
resistance gene varies among cultivars; a
new method, developed by University of Illinois researchers, is able to efficiently quantify this variation for the first time.
The study found several
genes that are associated with
resistance to antibiotics, including
new genes that might point to previously unknown mechanisms of drug
resistance.
But by investigating the DNA sequence around the
resistance genes, the team figured out how the
resistance genes transfer occurred through a
new mechanism named «carry back,» where the pathogen basically has a primitive form of «sex» with the Actinobacterium and takes up its
resistance genes after it dies.
The effort has already had one practical result: the discovery of two
new genes for
resistance to a race of wheat stem rust to which there is virtually no
resistance in wheat.
A faulty
gene that causes insulin
resistance may be a causative factor in nearly half of all families with obesity, a
new study suggests.
«This
new resistance locus is particularly interesting because it lies so close to
genes that are gatekeepers for the malaria parasite's invasion machinery.
A second carbapenem
resistance gene, NDM - 1, was identified in 2006 in
New Delhi, India.
Now, a team led by microbiologist Tim Kunkel of The Rockefeller University in
New York City has shown that at least two crops — lettuce and tobacco — can be engineered without using antibiotic
resistance genes.
New gene drive approaches will be necessary to overcome the challenge posed by
resistance, especially in genetically diverse, natural populations.
«Not only will knowledge about this
gene enable us to detect the early signs of pests evolving
resistance to the current engineered plants,» co-author Fred Gould of North Carolina State University notes, «it may also allow us to modify the plants so they will be defended against the
new pest strains.»
It will also allow for easier identification of
genes that contribute to the bacteria's spread from patient to patient, and more meaningful scientific experiments to understand the bug's
resistance to antibiotics or identify
new antimicrobial compounds that target specific
genes necessary for maintaining these persistent infections.
Once scientists understand how these
genes influence antibiotic
resistance, they could try to design
new drugs that mimic the effects, Lu says.
Led by Newcastle University, UK, the study also showed that the repeated use of animal manure and antibiotic substitutes can increase the capacity of soil bacteria to mobilise, or ready themselves, and acquire
resistance genes to
new antibiotics.
Tackling antibiotic
resistance on only one front is a waste of time because resistant
genes are freely crossing environmental, agricultural and clinical boundaries,
new research has shown.
«
New technology could reduce spread of antibiotic
resistance genes through compost.»
New research in Physiological Reports shows that although both
resistance and endurance exercises activate the PGC - 1α
gene, the adaptation processes stimulated are not the same and depend on the type of exercise.
Previous research by Professor Keevil and Dr Warnes has proved copper's efficacy against norovirus, influenza and hospital superbugs, such as MRSA and Klebsiella, plus stopping the transfer of antibiotic
resistance genes to other bacteria to create
new superbugs.
New Danish research has now revealed that the most common
resistance genes in wastewater treatment plants are not to be found among bacteria outside these facilities — in people or animals, for example.
«Genetic link to susceptibility and
resistance to inflammatory bowel disease: Overexpression of the Cd14
gene offers protection against IBD in mice, suggesting a
new therapeutic approach.»
«If we could understand better how these proteins with these additional «integrated» domains were formed during recent evolution, then there is a good chance that we could engineer
genes with specific domains to provide
resistance to
new types of pathogen attack,» says Paul Bailey, lead author of the study who performed the phylogenetic analysis.
A
new genomics study of shark DNA, including from great white and great hammerhead sharks, reveals unique modifications in their immunity
genes that may underlie the rapid wound healing and possibly higher
resistance to cancers in these ocean predators.
The scientists have not yet attained these record yields, since the
new variety still lacks crucial
genes for pest and disease
resistance.
Noticing an odd
resistance profile, first author Vincenzo Di Pilato, Ph.D., reanalyzed the genome data from the bacterium, and discovered the
new gene, which is a variant on the colistin - resistant
gene, mcr - 1.
The
new finding suggests that this may not be a useful a strategy in the future, because if the resistant rats hold their own or become dominant, the
gene for
resistance will not disappear.
«We suspect that one of the primary factors that drives the sharing of antibiotic
resistance genes is exposure to
new antibiotics,» Dantas said.
But what our studies suggest is that there is a whole
new universe where you can now screen for other functions, like the ability to block conjugation or to induce the loss of
resistance genes.
Her work - published in December 2007 - revealed
genes involved in drug
resistance and in evading the immune system, giving researchers potential targets for
new therapies and vaccines.
A Mailman study of
New York City mice found that they harbor multiple pathogenic bacteria, including some with an array of antimicrobial
resistance genes.
, researchers report at least one confirmed
new set of
genes that aids in
resistance.
In a study published Wednesday in Nature, researchers report at least one confirmed
new set of
genes that aids in
resistance.
Monitoring parasite populations for a specific genetic background — in this case, a fixed set of four well - defined mutations in the fd, arps10, mdr2, and crt
genes — could allow researchers to assess the likelihood of
new resistance - causing mutations emerging in different locations, helping to target high - risk regions even before resistant parasites take hold.
Chemical controls are costly and potentially harmful to human and environmental health, so protecting crops like wheat with inherent
resistance is the smart alternative, but
resistance must be genetically complex, combining several
genes, to withstand
new mutations of the pathogen over time.
The antibiotic
resistance genes present in genetically modified foods are already easily found in any human intestine in a form that frequently moves around between different bacteria and can easily take up residence in
new bacteria.