Sentences with phrase «new sequencing methods»

What we have glimpsed through this pioneering study is a future in which new sequencing methods will help us to identify, manage and stop hospital outbreaks and deliver even better patient care.»

Not exact matches

Considering that mutations, to name one method of generating new DNA sequences, can be detrimental as well as beneficial and each to varying degrees of hurt or help, I seriously doubt that just the number of DNA changes would be such a measure, even if such a number could be known given possibility of overwrites and deletions.

Now Pääbo and his colleagues have devised a new method of genetic analysis that allowed them to reconstruct the entire Denisovan genome with nearly all of the genome sequenced approximately 30 times over akin to what we can do for modern humans.

This new sequencing approach can be used for any DNA that is too fragmented to be read well through more traditional methods.

New methods for the removal of contaminating DNA from microbes and present - day humans that were developed by the Leipzig group have now enabled the researchers to sequence the genomes of five Neandertals from Belgium, France, Croatia, and Russia that are between 39,000 and 47,000 years old.

The new method could unlock a wealth of untapped chloroplast genome sequence data that can be applied to evolutionary studies.

The new method by Garaycochea and colleagues will enable researchers to strategically analyze this whole - genome sequence data and assemble the chloroplast genome for their plant of interest.

As costs come down and methods become more standardized, experts in the field expect single - cell sequencing to become the new model for both transcriptomic and genomic studies.

The new study, led by Johannes Krause, a geneticist at the Max Planck Institute for the Science of Human History in Jena, Germany, used next - generation sequencing methods to read stretches of any DNA present in a sample and fish out those that resembled human DNA.

The sequenced genome can lead to improved molecular biology, physiology and neurobiology research in insects and also may help in developing future new methods for insect pest management.

For this purpose, the scientists combined a sophisticated bioinformatics strategy developed by Masaomi Hatakeyama that uses state - of - the - art sequencing methods with a new technology that can optically map the long, individual DNA molecules in the genome.

A new high - coverage DNA sequencing method reconstructs the full genome of Denisovans — relatives to both Neandertals and humans — from genetic fragments in a single finger bone

Sequencing ancient DNA is expensive, so it can be hard for new labs to enter the field, but efforts are underway to develop methods to bring down the cost and make the field more accessible to newcomers.

A new study published in The Journal of Molecular Diagnostics has established that hybrid - capture sequencing is the method of choice for sequencing «actionable» gene mutations across the most common forms of lymphoid cancer.

A new technique which colour codes DNA for laser sequencing may offer a faster and cheaper way of sequencing genomes compared with conventional methods.

Large - scale methods of probing samples, such as DNA sequencing, microarrays, and automated gene - function studies, are filling new databases to the brim.

His laboratory develops and deploys new biochemical and computational methods in functional genomics, to elucidate the genetic basis of human disease and human physiology, and to create and deploy novel techniques in next - generation sequencing and algorithms for tumor evolution, genome evolution, DNA and RNA modifications, and genome / epigenome engineering.

A new, less expensive, and faster method now has been developed and used to determine the DNA sequence of the male - specific Y chromosome in the gorilla.

The key to the new method's improved performance is its ability to compare data to so - called spectral libraries — essentially a pattern - matching exercise — rather than individual spectra or a database of sequences.

They embark on wild flights of fancy, single - handedly coming up with a cure for AIDS, a new method for genomic sequencing, and the key to human evolution before you've even finished your morning coffee.

Reported in Nature Methods today, the new open source computer tool called Single Cell Consensus Clustering (SC3) was shown to be more accurate and robust than existing methods of analysing single - cell RNA sequence data, and is freely available for researchers Methods today, the new open source computer tool called Single Cell Consensus Clustering (SC3) was shown to be more accurate and robust than existing methods of analysing single - cell RNA sequence data, and is freely available for researchers methods of analysing single - cell RNA sequence data, and is freely available for researchers to use.

When hackers learn about a new method of attacking websites, they search the web for code sequences that reveal which sites are vulnerable.

Dr Vladimir Yu Kiselev, first author from the Sanger Institute, said «We created the new SC3 tool to analyse complex single - cell RNA - sequence data, and showed that it is more robust and accurate than existing methods at grouping cells.

Biologists and informatics experts are launching a quiet revolution aimed at building better genomes, one made possible by newer sequencing technologies, novel methods for locating sequences on chromosomes, and improved software for piecing DNA together.

The new method takes two weakly random sequences of numbers and turns them into one sequence of truly random numbers.

This new method sidesteps both of those restrictions and allows the use of two sequences that are only weakly random.

In contrast to the conventional analytical method which is limited to single - stranded regions of RNA, the new analytical method allows for fluorescent sensing of target dsRNA structure and sequence for the first time.

Later, Hendrik and George together pioneered new methods of extracting and sequencing ancient DNA.

Now a team at the Wyss Institute of Biologically Inspired Engineering at Harvard University and Harvard Medical School, in collaboration with the Allen Institute for Brain Science, has developed a new method that allows scientists to pinpoint thousands of mRNAs and other types of RNAs at once in intact cells — all while determining the sequence of letters, or bases, that identify them and reveal what they do.

The research team developed a new method called highly multiplexed single - nucleus sequencing (HM - SNS) to investigate CNA's clonal substructure and evolution in a cohort of 12 TNBC patients, whose tumors had been surgically removed prior to further therapy.

Existing technology, known as next - generation sequencing (NGS), measures genomes derived from millions of cells versus the newer method for single - cell sequencing, called Monovar.

Now with these new methods, we can get the DNA from these very old specimens and sequence extinct species like the Ivory Billed Woodpecker, the Tasmanian Wolf and the Dodo Bird,» Austin said.

This achievement marks the first big test of a new analysis method that can speed up genome assembly by compressing the raw sequence data 100-fold.

To develop the new method, the researchers needed a machine powerful enough to process millions of DNA sequences.

The key to the solution was using a new method to pre-process the gargantuan pile of sequence data so that it could all fit within the working memory of a single super-computer.

«We have also used a newer method called Illumina sequencing.

Dr. Donovan Bailey, senior author of the study and professor at New Mexico State University, said this approach has several advantages over previously established methods for enriching either nuclear or organellar DNA for genome sequencing.

Unlike current methods of synthesising oligonucleotides, where the number of errors increases with the length of the sequence, this new method according to the developers also works well for long oligonucleotides of several hundred nitrogenous bases.

In a stunning technical feat, an international team of scientists has sequenced the genome of an archaic Siberian girl 31 times over, using a new method that amplifies single strands of DNA.

The researchers gathered single cells of warnowiids off the coasts of B.C. and Japan, sequenced their genomes, and analyzed how the eyes are built using new methods in electron microscopy that allow the reconstruction of three dimensional structures at the subcellular level.

Using next - generation sequencing, the U.K. team showed that the iPS cells» genome was «clean» — the gene - editing methods had not added any new mutations.

Deeper understanding — and new medical treatments — requires many more sequenced genomes, as well as cheaper and faster sequencing methods.

In the new study, Sunney Xie of Peking University and Harvard University teamed up with Qiao and Fuchou Tang of Peking University to develop a method for sequencing the entire genomes of polar bodies — cells that arise as a byproduct of egg cell division and often die later on.

Through whole - genome sequencing of individual egg cells, the new method detects chromosomal abnormalities and DNA sequence variations associated with genetic disorders.

My group's research focuses on the development of new computational methods for analysis of DNA from the latest sequencing technologies.

Data was generated with a new method that uses a modern DNA sequencer that produces hundreds of millions of sequences, giving the results unprecedented accuracy and reliability.

The new deep sequencing methods allow data to be acquired much more efficiently and inexpensively, but optimal methods are less well developed (for some recent work in this area see [8, 14, 26]-RRB-.

New deep sequencing methods provide a convenient platform for characterizing the composition of the human microbiota [4, 7, 8, 13, 15 — 19].

TEST CASE RESEARCHER Piroska Szabó, Associate Professor, Center for Epigenetics, Van Andel Research Institute ORGANISM Mouse METHOD RNA - seq In 2014, Szabó and colleagues reported how they'd used mouse embryonic fibroblasts to test whether the relatively new method of RNA sequencing could reveal known and novel imprinted METHOD RNA - seq In 2014, Szabó and colleagues reported how they'd used mouse embryonic fibroblasts to test whether the relatively new method of RNA sequencing could reveal known and novel imprinted method of RNA sequencing could reveal known and novel imprinted genes.

For the first time, researchers have the ability to analyse malaria genomes straight from patient blood samples using new sequencing technologies and informatics methods.