Sentences with phrase «new small molecule»

In addition, new small molecule drugs are being used that target important survival pathways in NHL tumor cells.

It's still early days, but researchers report that they've discovered a new small molecule that binds selectively to a long - targeted enzyme, halting its role in pain and addiction while not interfering with enzymes critical to healthy cell function.

«When we discover a new small molecule, we have the advantage of knowing that it works in vivo,» he says.

Most of my cases involve new small molecules, biologics, proteins or agricultural products.

Not exact matches

The new research, published recently as two separate studies in ACS Central Science and the Journal of the American Chemical Society, demonstrates that a new class of drugs called small molecule RNA inhibitors can successfully target and kill specific types of cancer.

Now, researchers have demonstrated that two iron - containing small - molecule catalysts can help turn certain types of amino acids — the building blocks of peptides and proteins — into an array of potential new forms, even when part of a larger peptide, while preserving a crucial aspect of their chemistry: chirality, or «handedness.»

The new machine mimics the pumping mechanism of life - sustaining proteins that move small molecules around living cells to metabolize and store energy from food.

Supporting a rail system powered by hydrogen fuel cells, for example, would require an entirely new infrastructure because hydrogen, being a small molecule, would leak through existing pipelines.

The acidity of urine — as well as the presence of small molecules related to diet — may influence how well bacteria can grow in the urinary tract, a new study shows.

The new - generation microporous material designed at Dartmouth is the result of chemically stitching small organic molecules to form a framework that scrubs the isotope from water.

The automated synthesis technology has been licensed to REVOLUTION Medicines, Inc., a company that Burke co-founded that focuses on creating new medicines based on small molecules found in nature.

Visualizing this molecular structure creates a platform for designing new, more effective small molecule therapeutics to treat depression and anxiety.

The researchers created a new gel, based on small molecules which self - assemble into nanofibers which could interact with a variety of anti-inflammatory, painkiller drugs, including iburofen and naproxen.

Chemical biologists hope a new Internet portal will improve information on small, druglike molecules that are used to study protein vital to human health and disease.

Published in the journal Cell Stem Cell, the researchers, in collaboration with co-senior author Lei Stanley Qi, PhD, at Stanford University, successfully identified two small molecules that significantly improve the insertion of new genetic information into a cell's DNA.

If it can be developed into a successful technology, the new material might help remove from the water supply small organic molecules such as Bisphenol A (BPA), a byproduct of some plastic manufacturing that has been linked to environmental damage and health risks.

Nanotechnology has unlocked new pathways for targeted drug delivery, including the use of nanocarriers, or capsules, that can transport cargoes of small - molecule therapeutics to specific locations in the body.

The advancement, using a new kind of synthetic polymer (a polymer is a large molecule composed of many repeated smaller molecules) has self - healing properties that mimic human skin, which means that e-skin «wounds» can quickly «heal» themselves in remarkably short time — less than a day.

This work hopes to contribute to setting the path toward a new generation of more reliable computational tools with regard to predicting the adverse effects of therapeutically - relevant small molecules.

The researchers behind the new study, from Winston - Salem State University in the US and Universiti Malaysia Sarawak in Malaysia, have found that adding similar, but smaller polycationic molecules onto a new kind of material called carbon nanodots makes them even better at killing drug - resistant bacteria.

The new finds join a list of about 125 smaller carbon - based molecules identified in space so far.

The new drug, a small molecule called anle138b, blocks these pores from moving ions in and out of nerve cells.

An international team of researchers has shown that a new small - molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease.

«All of the new molecules are based on the same basic skeleton, with very small differences between them.

The process allows small, synthetic molecules to exhibit the functional diversity of much larger enzymatic catalysts, and offers a promising new tool for synthesizing therapeutics based on natural products.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

The design inspiration for the new particles came from the natural world — specifically, small particles known as lipoproteins, which transport cholesterol and other fatty molecules throughout the body.

Published in the August 2015 issue of Nature Medicine, the new findings show that a small molecule called N1 - methylnicotinamide prevents metabolic complications caused by a high - fat diet.

New hope for improved detection comes in the form of small RNA molecules called microRNAs.

But new research from the Salk Institute suggests that a small molecule may be able to convince damaged nerves to grow and effectively rewire circuits.

As a postdoctoral researcher at Harvard Medical School, he investigated the use of small - molecule drugs to manipulate signaling pathways to enable otherwise senescent progenitor cells of the cochlea to divide and form new sensory cells.

New research into Rett syndrome therapeutics suggests that a small molecule already reported to improve respiratory problems associated with the disease may also improve spatial memory and motor skill defects.

All three labs used a technique that Tuschl had developed to clone small RNA molecules, and their results — 103 new microRNA genes in all — were published together in the journal Science in October 2001.

The new method gives scientists more power not only to find new antibody - based therapies, but also to discover the biological pathways through which they work — pathways that may turn out to be more easily and cheaply targeted by small - molecule drugs.

The GPCRs solved to date all required adding small druglike molecules in order to stabilize them, says Raymond Stevens, a structural biologist at the University of Southern California (USC) in Los Angeles, who will lead the new consortium.

A new class of experimental drug - like small molecules is showing great promise in targeting a brain enzyme to prevent early memory loss in Alzheimer's disease, according to Northwestern Medicine ® research.

To investigate a possible new therapy to treat West Nile Virus disease, Kumar and her colleagues focused on a small «interfering» RNA molecule developed in her lab.

«If we could design a small molecule inhibitor that would look like heme - iron but would actually clog up a key metabolic pathway in bacteria, we may be able to get around the problem of antibiotic resistance,» suggests Dr. Mason, who adds that he and Dr. Justice plan to use the new five - year NIH grant to further studies of just such an inhibitor.

New research at Rockefeller University and Columbia University suggests these small molecules may be able to relay valuable information about damage to the heart: Scientists in Thomas Tuschl's Laboratory of RNA Molecular Biology have linked an increase in certain microRNAs circulating in the blood with injury to cardiac muscle.

The upcoming shift in focus toward large - scale screening of small - molecule collections will provide both opportunities and challenges for graduate students and postdocs wishing to explore this new domain of academic research.

Small RNA molecules originally developed as a tool to study gene function trigger a mechanism hidden in every cell that forces the cell to commit suicide, reports a new Northwestern Medicine study, the first to identify molecules to trigger a fail - safe mechanism that may protect us from cancer.

A new study that included researchers from Norway, the University of Washington, the University of California San Diego and The University of Texas Health Science Center at San Antonio (now called UT Health San Antonio ™) found that dozens of small molecules called metabolites are altered in this disease.

Efforts to inhibit this enzyme, called β - secretase 1 (BACE1), with small molecule drugs have met with limited success so far, says Ryan Watts, a neurobiologist at the biotech company Genentech in South San Francisco, California, and one of the leaders of the new research.

Karenia also makes small molecules that are toxic to other marine algae, which is what the new study analyzed.

A small molecule in cells that was previously believed to have no impact on animal behaviour could in fact be responsible for controlling precise movements, according to new University of Sussex research.

The new research has shown that the small calcium molecule is the messenger in the communication.

In response to that need, Cravatt and colleagues have been developing new methods to discover and map the sites on proteins where small - molecule probe can bind.

The initiative will also allow the CMI to foster new partnerships between academia and industry, and utilize the individual strengths that each possess to expedite the early stages of small molecule drug discovery.

Using the new method, published on July 31, 2017 in Nature Chemistry, the TSRI scientists identified more than 100 human proteins that are likely to be targetable with small molecule, pill - based drugs.

«This research very nicely demonstrates how collaboration among scientists with diverse areas of expertise, ranging from genomics to small molecule chemistry, can lead to new insights into plant defensive metabolism,» said BTI Professor Georg Jander, a co-author of the paper.