Sentences with phrase «new small molecule drugs»

In addition, new small molecule drugs are being used that target important survival pathways in NHL tumor cells.

Not exact matches

The new research, published recently as two separate studies in ACS Central Science and the Journal of the American Chemical Society, demonstrates that a new class of drugs called small molecule RNA inhibitors can successfully target and kill specific types of cancer.

The researchers created a new gel, based on small molecules which self - assemble into nanofibers which could interact with a variety of anti-inflammatory, painkiller drugs, including iburofen and naproxen.

Nanotechnology has unlocked new pathways for targeted drug delivery, including the use of nanocarriers, or capsules, that can transport cargoes of small - molecule therapeutics to specific locations in the body.

The researchers behind the new study, from Winston - Salem State University in the US and Universiti Malaysia Sarawak in Malaysia, have found that adding similar, but smaller polycationic molecules onto a new kind of material called carbon nanodots makes them even better at killing drug - resistant bacteria.

The new drug, a small molecule called anle138b, blocks these pores from moving ions in and out of nerve cells.

An international team of researchers has shown that a new small - molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

As a postdoctoral researcher at Harvard Medical School, he investigated the use of small - molecule drugs to manipulate signaling pathways to enable otherwise senescent progenitor cells of the cochlea to divide and form new sensory cells.

The new method gives scientists more power not only to find new antibody - based therapies, but also to discover the biological pathways through which they work — pathways that may turn out to be more easily and cheaply targeted by small - molecule drugs.

A new class of experimental drug - like small molecules is showing great promise in targeting a brain enzyme to prevent early memory loss in Alzheimer's disease, according to Northwestern Medicine ® research.

Efforts to inhibit this enzyme, called β - secretase 1 (BACE1), with small molecule drugs have met with limited success so far, says Ryan Watts, a neurobiologist at the biotech company Genentech in South San Francisco, California, and one of the leaders of the new research.

The initiative will also allow the CMI to foster new partnerships between academia and industry, and utilize the individual strengths that each possess to expedite the early stages of small molecule drug discovery.

Using the new method, published on July 31, 2017 in Nature Chemistry, the TSRI scientists identified more than 100 human proteins that are likely to be targetable with small molecule, pill - based drugs.

Small - molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs.

Not a light read, this tome is bursting with information about monoclonal antibodies, from the history of how these therapies were first developed to new approaches such as conjugate therapy, which combines antibodies with small - molecule drugs.

«This partnership puts our mRNA Therapeutics platform in the hands of Karolinska's world - class scientists and clinical researchers to develop new drugs and therapeutic approaches that can not be done with small molecules or biologics — bringing new hope to patients with serious diseases.»

Vescor, advised by its scientific founders White and Kimmelman, whose research has shown inhibition of autophagy can dramatically impact tumor growth in pre-clinical models, will develop small molecule inhibitors of a number of protein targets at critical nodes of the autophagy cascade, perform investigational new drug (IND) enabling studies, and move these into clinical development.

MIT's new nanoparticle carries three cancer - fighting drug molecules — doxorubicin is red, the small green particles are camptothecin, and the larger green core contains cisplatin (Image: Jeremiah Johnson)

Orders of magnitude more sensitive than conventional Raman microscopy, they allow mapping of 3D distributions of small molecules, such as metabolites and drugs, as well as tumor identification in tissues, which open many exciting new possibilities for biology and medicine.

Then for postdoctoral research I moved to Yale University, where I worked in a lab that looked at all kinds of different disease areas using the approaches of a field called chemical biology, which is using small molecules — chemicals — to probe biological systems in the hopes of developing compounds that could be new drugs.

Reykjavik, ICELAND, January 13, 2005 — deCODE genetics (Nasdaq: DCGN) has submitted an investigational new drug application (IND) to the U.S. Food and Drug Administration (FDA) for DG041, a novel, first - in - class, orally - administered small molecule for the treatment odrug application (IND) to the U.S. Food and Drug Administration (FDA) for DG041, a novel, first - in - class, orally - administered small molecule for the treatment oDrug Administration (FDA) for DG041, a novel, first - in - class, orally - administered small molecule for the treatment of...

Published June 25, 2015 in Molecular Cell, the new study identifies a small molecule drug that specifically blocked the first step of autophagy, effectively cutting off the recycled nutrients that cancer cells need to live.

eFFECTOR is pioneering a new class of small molecule drugs that act by selectively regulating translation, also known as protein synthesis.

As part of the global effort toward malaria eradication, phenotypic whole - cell screening revealed the 2 - aminopyridine class of small molecules as a good starting point to develop new antimalarial drugs.

I am interested in Scientist position for designing and developing novel small molecules, developing new synthetic routes and process optimization, for drug discovery and development.