Sentences with phrase «new therapeutic»
The overall aim of the Group is to determine the roles of the individual transporter subtypes in order to better understand normal physiology and disease, and to uncover new therapeutic opportunities.
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The aim is to identify the genetic causes, understand the pathology, prevent the transmission and, finally, develop new therapeutic approaches for these devastating often fatal disorders.
Understanding the genetic factors that regulate synaptic plasticity could point to new therapeutic approaches for human diseases that disrupt synaptic connections.
This includes utilizing a modified chimpanzee virus as a vaccine carrier to induce an immune response against HIV, and a new therapeutic vaccine against human papillomavirus (HPV), a leading cause of cervical cancer.
Better knowledge on protective mechanisms of one sex, for cardiometabolic and renal complications and psychological disorders, could help to establish new therapeutic strategies for both sexes.
«This perspective will offer us a window into new therapeutic targets for these diseases.»
PHENOMIN - ICS offers to generate genetically modified mouse models on a high - throughput and large scale basis, and then to provide a first phenotyping characterisation, either standardised or more specific, for a better understanding of disease mechanisms and for the development of new therapeutic treatments.
Our collaborations with industry, government agencies, and academia focus on developing new disease models, elucidating new therapeutic targets to develop treatments, safety testing on new chemical entities, enabling better and safer design of new consumer products, and new applications in personalized healthcare.
I look for genes, pathways, and candidate mutations associated with a disease, in order to understand the mechanism and the etiology of a disease, which may eventually lead to new therapeutic targets.
Development of advanced preclinical models are needed to further elucidate the complex mechanisms underlying asthma exacerbation and investigate new therapeutic strategies.
One of its priorities is to develop relevant strategies to decipher multiple forms of neuromuscular diseases, identify new therapeutic targets and foster novel strategies for innovative treatments.
This discovery — authored by UCSD investigators Severine Boillee, Koji Yamanaka, Cleveland and others and published in the June 2 issue of the journal Science — confirms the importance of the new therapeutic approach, which delivers an antisense drug directly to the whole nervous system, including non-neuronal cells.
Monoclonal antibodies now account for roughly half of all new therapeutic products under development, and those already on the market generated $ 48 billion in global sales in 2010.
The condition is more common than muscular dystrophy and cystic fibrosis, but the development of new therapeutic concepts is hindered by the fact that unlike muscular dystrophy and cystic fibrosis, where a single mutated gene causing the disease is known, the entire human chromosome 21 (containing around 300 genes) still has to be dissected into individual gene - dose contributions to the DS symptoms.
Using pre-implantation genetic diagnosis derived human embryonic stem cell lines (hES) or human induced pluripotent stem cells carrying the causal mutation for neuro - muscular diseases, our objective is double: identify new physiopathogical mechanisms and develop new therapeutic strategies.
«The findings open new therapeutic avenues, particularly for the Group 3 and 4 subtypes, where patient outcomes are inferior for the majority of affected children,» said Paul Northcott, PhD, of St. Jude Developmental Neurobiology.
This discovery makes it possible to screen for the disease, and opens the door for potential new therapeutic approaches.
The Cell Surface Signalling Laboratory investigates the molecular basis of cellular recognition processes to identify new therapeutic targets for both genetic and infectious diseases.
Professor Nizetic, calling for further research into the components of the disturbed cascade he and his team have revealed said; «We hope that further research might lead to clues for the design of new therapeutic approaches tackling developmental delay, mental retardation, ageing and regeneration of brain cells, and Alzheimer's disease.
Jan. 26, 2018 — New research reveals a unique mechanism of C. difficile toxin neutralization by a monoclonal antibody, suggesting new therapeutic approaches.
Additional studies in even larger patient populations, some of which are in the planning stages, could identify the biologic pathways disrupted in the disorder, potentially leading to new therapeutic approaches.
Improving our understanding of the relationship between changes in the retinal microvasculature, RNFL and lamina cribrosa in the pathophysiology of glaucoma can inform the development of new therapeutic targets designed to slow the microvasculature changes as a new non-IOP lowering approach to glaucoma therapy.
These promised to provide a new therapeutic target for treating obesity, with the researchers finding that they share the fat - burning abilities of brown cells, though they do decrease in number as we approach middle age.
Our work decoding new components of the energy - sensing pathway has also led to new therapeutic targets for many difference forms of cancer, which alter these same pathways through many different mechanisms.»
Scientists at the Gladstone Institutes discovered that an enzyme called SMYD2 could be a new therapeutic target for flushing out the HIV that hides in infected individuals.
Currently, as a principal investigator, because of the overlap of CAA and AD, I have used my background knowledge of the cerebrovasculature system to study new therapeutic strategies for AD.
In particular, common neurological conditions such as stroke, Alzheimer's disease, Parkinson's disease and other chronic neurodegenerative diseases, age - related cognitive impairment, epilepsy, mood disorders and schizophrenia call for new therapeutic strategies.
The understanding of cell identity, heterogeneity and plasticity in neuroblastoma has strong implications with respect to the development of new therapeutic strategies to eradicate tumor cells in neuroblastoma patients.
Melanie Ott (left) and Daniela Boehm (right) uncovered a new therapeutic target for flushing out latent HIV.
In parallel to these functional pathological studies, we also demonstrated the pertinence of this new disease - specific cell model to identify new therapeutic strategies.
This may lead to development of a diagnostic test as well as identification of new therapeutic targets.»
The Cell Surface Signalling Laboratory is interested in identifying new therapeutic targets for both genetic and infectious diseases by using large - scale systematic approaches to discover receptor - ligand interactions that are essential for cellular recognition processes.
A group of NUST MISIS's young scientists has presented a new therapeutic material based on nanofibers made of polycaprolactone modified with a thin - film antibacterial composition and plasma components of human blood.
Our aim is to highlight the genetic networks that can impact on DM1 biomarkers to provide new therapeutic targets for treatments by chemical compounds.
This technology helps researchers connect mutations in the so - called genomic «dark matter» with the genes they affect, potentially revealing new therapeutic targets for genetic disorders.
Examination of such mechanisms by which the brain naturally protects itself may lead to more selective cellular and molecular targets, as well as new therapeutic strategies against brain disease.
The conference aims at bringing together international experts from different fields of cancer research to present and discuss new therapeutic approaches regarding different tumor entities as well as new findings in the field of tumor biology seeking to incorporate innovative platforms into cancer research.
Our objective is to devise new therapeutic approaches for the treatment of respiratory infections.
Understanding disease biology through basic research accelerates the identification of new therapeutic approaches.
His studies may kindle new therapeutic strategies relevant to a broad range of cancers.
How Parkinson's Gene may lead to New Therapeutic Strategies for Breast Cancer MyCentralJersey.com — December 1, 2017
The advancement of the Cas9 - based platform for screening and validation will help further the development of new therapeutic products, and Caribou's CRISPR - Cas9 technology can utilize guide RNAs specific for unique sequences and target a gene at numerous sites and therefore provide enhanced specificity.
«BMP7 is active in stimulating brown fat development in cells in culture and in test animals, so we are very excited in having this opportunity to determine its potential as a new therapeutic approach for obesity and type 2 diabetes,» said Dr Ronald Kahn.
The Microbiology Services Division at Porton Down, part of the National Infection Service directorate, has extensive high - containment laboratory facilities and rare capabilities to handle infectious organisms under the highest levels of containment, and the ability to work with in vivo models to evaluate new therapeutic interventions against these organisms.
«This project could lead to new therapeutic targets and more effective and safer drugs for the disease.»
Find new therapeutic approach to halt or to cure muscle atrophy are our main objectives regardless of etiology.
Zerbini G, Piemonti L, Maestroni A, Dell» Antonio G, Bianchi G. Stem cells and the kidney, a new therapeutic tool?
In order to use these DM1 - specific biomarkers to develop new therapeutic treatments, we successfully developed technical assessments of miniaturization to realize high content screenings based on detection of the nuclear aggregation of the mutant mRNA.
Researchers studying the heterogeneous nature of cancer stem cell - containing skin tumors may have discovered new therapeutic targets
Review: New Therapeutic Drugs from Bioactive Natural Molecules: the Role of Gut Microbiota Metabolism in Neurodegenerative Diseases — Francesco Di Meo — Current Drug Metabolism