Sentences with phrase «new therapeutic approaches in»
Beyond the potential for new therapeutic approaches in treating MDS or AML, the paper revealed a new and critical immune - related function for TRAF6, according to the authors.
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During his twelve years at a child guidance center in Rochester, New York, his therapeutic orientation changed from a formal, directive approach toward what became client - centered therapy.
The study also reinforces the potential value of brain scans for identifying and understanding schizophrenia in individual patients, for finding promising new therapeutic approaches, and for helping clinicians track a patient's progress during therapy.
In precision medicine era legacy gifts of patient brain tissue reveal disease mechanisms and new therapeutic approaches
The findings by a team of Massachusetts General Hospital (MGH) investigators, which will be published in the April 24 issue of Cell and are receiving advance online release, support the importance of epigenetics — processes controlling whether or not genes are expressed — in cancer pathology and identify molecular circuits that may be targeted by new therapeutic approaches.
«Our new study indicates that a differential therapeutic approach can be beneficial for older patients in melanoma and suggests that age should be taken into account to design better treatments for certain cohorts of patients.»
Merlin and his VA and Georgia State University coauthors elaborated on the idea in a report earlier this year titled «Plant - derived edible nanoparticles as a new therapeutic approach against diseases.»
But in the future, this new line of research may offer a therapeutic approach for kids with Prader - Willi, Langouet says.
In addition to uncovering compounds with therapeutic potential for Alzheimer's disease, this research presents a new approach for identifying proteins that bind to amyloid fibrils — an approach that could have broad applications for treating many diseases.
This work provides a proof of principle for a new approach in the study and treatment of cancer: the aberrant expression in a tissue or organ of genes specific to other tissues could become a new tool for establishing a prognosis and personalizing therapeutic care.
The continuation of this line of research is opening new avenues to identify what specific signals are used to promote this increased neurogenic response, with views focused in targeting neurogenesis as a therapeutic approach to promote the regeneration of lost neurons.»
«We are introducing a potential new therapeutic approach that is particularly useful in preventing new metastatic disease from forming,» said Desgrosellier.
Dr. Paul R. Sanberg, Distinguished University Professor, a co-author of the paper, concluded that «these novel data showing BSCB damage in subacute and chronic ischemic stroke may lead to development of new therapeutic approaches for patients with ischemic cerebral infarction.»
The study, which will be published December 21 in the Journal of Cell Biology, suggests that the loss of these particular Numb proteins makes breast cancers more aggressive and resistant to chemotherapy, but points the way toward new therapeutic approaches that could improve patient outcome by preserving p53 levels.
«We have also demonstrated that the immune system can be manipulated in a manner that accelerates this process, potentially pointing to a new therapeutic approach to Alzheimer's disease.»
Understanding how the fish remain healthy in spite of these ominous symptoms may lead to new therapeutic approaches for treating diabetes in people, notes Cliff Tabin, a geneticist at Harvard Medical School.
Natural killer cells serve important roles in clearing non-type 2 inflammatory cells, so identification of a defect in NK cell function in severe asthma provides a window for the development of new therapeutic approaches.
The study, published September 7 in Nature Medicine, provides promise for a new therapeutic approach to treating the millions of people suffering from muscle diseases, including those with muscular dystrophies and muscle wasting associated with cancer and aging.
Acupuncture, Tai chi, Qigong, therapeutic massage and five elements musical intervention were among the approaches evaluated in a new analysis of traditional Chinese medicine and its effects on quality of life in Chinese cancer patients.
«Genetic link to susceptibility and resistance to inflammatory bowel disease: Overexpression of the Cd14 gene offers protection against IBD in mice, suggesting a new therapeutic approach.»
The study, published May 6, 2016 in Cell Stem Cell, also shows that inhibiting this mechanism reduces brain cell damage, hinting at a new therapeutic approach to mitigating the effects of prenatal Zika virus infection.
«These studies identify telomeres as a new molecular route implicated in the origin of liver diseases such as cirrhosis, hepatitis or liver cancer, as well as novel therapeutic approaches to prevent and combat them,» concluded the researchers.
«The current study reveals the new roles of innate immunity in ALS pathomechanism and provides a clue to develop a new therapeutic approach for protecting ALS motor neurons.»
Scientists in Germany have developed a new approach that may prevent leukemia and lymphoma patients from developing graft - versus - host disease (GvHD) after therapeutic bone marrow transplants.
«Extra-coding RNAs regulate DNA methylation in the adult brain: The ecRNAs appear to act in memory formation, and may offer a new therapeutic approach to neuropsychiatric diseases..»
Traditional therapeutic approaches often encourage depressed patients to participate in enjoyable situations, yet the new findings suggest that some people may first need to practice allowing themselves to feel any pleasant emotions at all.
In addition, he believes that understanding this metabolic pathway can lead to new therapeutic approaches to aging.
«This mechanism may offer the potential to develop an entirely new therapeutic approach,» says C. Ronald Kahn, M.D., Joslin's chief academic officer, Mary K. Iacocca Professor of Medicine at Harvard Medical School and senior author of a paper on the research published in the journal Nature.
These results, published in the journal Nature, could be used to develop new therapeutic approaches.
Our goal is, through the greater understanding of pathological mechanisms implicated in this disease, to identify new therapeutic strategies for this neuromuscular disease and to extend this experimental approach to other neuromuscular diseases.
new technological advances in the field of live imaging [e.g. magnetic resonance imaging (MRI) and optical in - vivo imaging] to develop new preventive and / or therapeutic approaches for these diseases.
«BMP7 is active in stimulating brown fat development in cells in culture and in test animals, so we are very excited in having this opportunity to determine its potential as a new therapeutic approach for obesity and type 2 diabetes,» said Dr Ronald Kahn.
The call seeks to address the need for innovative research to underpin new approaches to therapeutic intervention, connect centres with a critical mass of resources and expertise to drive a step change in neurodegeneration research.
The conference aims at bringing together international experts from different fields of cancer research to present and discuss new therapeutic approaches regarding different tumor entities as well as new findings in the field of tumor biology seeking to incorporate innovative platforms into cancer research.
The Cell Surface Signalling Laboratory is interested in identifying new therapeutic targets for both genetic and infectious diseases by using large - scale systematic approaches to discover receptor - ligand interactions that are essential for cellular recognition processes.
These promised to provide a new therapeutic target for treating obesity, with the researchers finding that they share the fat - burning abilities of brown cells, though they do decrease in number as we approach middle age.
Improving our understanding of the relationship between changes in the retinal microvasculature, RNFL and lamina cribrosa in the pathophysiology of glaucoma can inform the development of new therapeutic targets designed to slow the microvasculature changes as a new non-IOP lowering approach to glaucoma therapy.
Additional studies in even larger patient populations, some of which are in the planning stages, could identify the biologic pathways disrupted in the disorder, potentially leading to new therapeutic approaches.
This discovery — authored by UCSD investigators Severine Boillee, Koji Yamanaka, Cleveland and others and published in the June 2 issue of the journal Science — confirms the importance of the new therapeutic approach, which delivers an antisense drug directly to the whole nervous system, including non-neuronal cells.
«This partnership puts our mRNA Therapeutics platform in the hands of Karolinska's world - class scientists and clinical researchers to develop new drugs and therapeutic approaches that can not be done with small molecules or biologics — bringing new hope to patients with serious diseases.»
Dr. Aldred's lab will evaluate a new therapeutic approach known as nonsense readthrough, testing two drugs that may be able to correct genetic defects in an important cell - signaling pathway.
«Usually that's useless because they are already inactive in that state, but this finding suggests we might be able to find new therapeutic approaches to target these diseases.»
The project has the potential to provide important new information about mechanisms of drug resistance in melanoma - a key medical problem - as well as to evaluate the potential of splicing inhibitors as a therapeutic approach in two groups of melanoma pts with different response kinetics.
The study, integration and analysis of these data increasingly allows to unravel the genetic mechanisms and networks underlying complex biological phenotypes paving the way for an era of «genomic medicine,» in which new diagnostic and therapeutic approaches to common multifactorial conditions are emerging.
Because of the laboratory's success in its study of immune response, Sette and his team believe their research will lead to development of new therapeutic and prophylactic approaches to fighting infectious diseases.
Defining the molecular changes in the striata of Parkinson's diseased brains is necessary to better understand the disorder and design new therapeutic approaches for its treatment.
«Our study demonstrates a new therapeutic approach to successfully target inflammation and fibrosis, representing a major advance in the field,» concluded Haldar.
Information gained from this work will serve to enhance the clinical usefulness of findings from genomic sequencing (for example, next - generation sequencing or comprehensive genomic profiling), determine therapeutic approaches based on genomic findings, aid in the development of clinical trials and related options, and provide supportive rationale for exploring new therapies.
These new understandings may lead to a novel therapeutic approach that improves muscle function in older individuals and in those with chronic diseases.
Dr. Lanteri is also interested in using the OMICS approach to identify predictive markers of disease outcome and new therapeutic targets.