Sentences with phrase «new therapeutic drugs»
Today, Zheng, associate professor of pharmacology at the University of Washington and an HHMI investigator, runs a triplicate of research agendas, all rooted in Xray Crystallography, and all aiming to find new therapeutic drugs for human diseases.
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Review: New Therapeutic Drugs from Bioactive Natural Molecules: the Role of Gut Microbiota Metabolism in Neurodegenerative Diseases — Francesco Di Meo — Current Drug Metabolism
«There are no new therapeutic drugs in development,» says Manjula Lusti - Narasimhan of the WHO's Department of Reproductive Health and Research.
Not exact matches
Though hailed as «a new therapeutic principle» in 1990, it nonetheless took another eight years for the FDA to approve the first antisense drug, fomivirsen — for the treatment of AIDS - related retinitis caused by human cytomegalovirus.
«It essentially gives us a periodic table,» Ron DePinho, President of MD Anderson Cancer Center says, which has provided us with both diagnostic and therapeutic value as well as helped us design clinical trials to accelerate the development of new cancer drugs,».
New drug - delivery particles could release therapeutic molecules in the body only after they reached their targeted diseased tissues.
«This could lead to a new therapeutic strategy for treating type 2 diabetes,» says Stanford, whose team believes that the drug could lead to fewer people with adult - onset diabetes becoming dependent on insulin injections.
These «designer» peptides could one day make up a new class of therapeutic drugs that is more effective and results in fewer side effects.
For now, Rashid's group has a list of candidate therapeutic drugs that they'll test in their new liver disease models, something that may still prove useful to patients.
Determining the detailed molecular mechanism that mediates the therapeutic actions of cannabidiol may suggest development strategies for new drugs aimed at GPR55, according to the researchers.
«This gives us novel and exciting new therapeutic options to pursue based on results from drug screenings of primary tumor samples from patients.»
«Using approved therapies for one condition to treat another, or drug repurposing, offers new avenues to speed Parkinson's therapeutic development,» said Dr Brian Fiske, senior vice president of research programs at MJFF.
These new markers and tests could also be used to assist in treating drug dependence, in determining appropriate therapeutic levels of medical marijuana, and for monitoring women who want to stop using cannabinoids during pregnancy.
Their control requires the continuous development of new and potent antiviral drugs / therapeutic options.
University of Calgary researchers including Luchman, Weiss and Dr. Greg Cairncross — director of SACRI, and leader of the Terry Fox Research Institute (TFRI) «Therapeutic Targeting of Glioblastoma research program at the university — are now working with cancer researchers Dr. Warren Mason (Princess Margaret Cancer Centre in Toronto) and Dr. Lesley Seymour (Director of the NCIC Clinical Trials Group's Investigational New Drug Program), and drug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastDrug Program), and drug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastdrug manufacturer AstraZeneca, to plan a clinical trial testing a similar, but newer, drug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastdrug related to AZD8055 (called AZD2014), in combination with TMZ, in patients with glioblastoma.
«Potent parasite - killing mechanism of anti-malarial drug uncovered: New understanding of how artemisinin works could facilitate development of new drugs and therapeutic strategies against malaria.&raqNew understanding of how artemisinin works could facilitate development of new drugs and therapeutic strategies against malaria.&raqnew drugs and therapeutic strategies against malaria.»
«And while the tumor model we're now studying doesn't present targets for new drugs, if we can discover the mechanism controlling that model, it may yield therapeutic drug targets.»
These drugs subsequently have low bioavailability (i.e., they are difficult for the body to take up), which limit their therapeutic efficacy and hence seldom leads to new pharmaceuticals.
Jusko says that, among his students, the hottest topics of interest involve biotech — particularly protein therapeutic agents — because many future new drugs will likely be biologicals.
A therapeutic screening center, headed by Lee Rubin at the Harvard Department of Stem Cell and Regenerative Biology, is dedicated to using induced pluripotent stem cells to find new drugs for genetic diseases.
A 1997 editorial in the New England Journal of Medicine noted that «it is difficult to titrate the therapeutic dose of this drug, and it is not widely prescribed.
Dr Ishwar Singh, a specialist in novel drug design and development from the University of Lincoln's School of Pharmacy, said: «Translating our success with these simplified synthetic versions from test tubes to real cases is a quantum jump in the development of new antibiotics, and brings us closer to realising the therapeutic potential of simplified teixobactins.
«Since 95 percent of cancer patients still get chemo, we realized we could make a major impact on cancer treatment by helping clinicians prescribe the right chemotherapy drug,» said Sourav Bandyopadhyay, PhD, a professor of bioengineering and therapeutic sciences in UCSF's Schools of Pharmacy and Medicine and senior author on the new study.
«These are the best - done and largest assessments of how the microbiome may influence therapeutic outcome» from those drugs, says immunotherapy researcher Jeffrey Weber of New York University in New York City, who was not involved in the studies.
The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.
A recent study by researchers at the University of Missouri School of Medicine has shown that a protein inhibitor drug prevents these blockages, and could be a new therapeutic approach to prevent heart attack, stroke and other diseases caused by blocked blood vessels.
The therapeutic benefits of the new drugs outweigh the risks, and often there aren't any alternatives.
The result is a new dual - targeting drug candidate — or, as Griffin describes, «one drug addressing multiple therapeutic indications» — that could treat both diabetes and bone disease.
«The induced pluripotent stem cells we used in this study proved to be extremely useful in disease modelling, and they could offer an excellent platform for drug discovery and testing new therapeutic targets for Alzheimer's disease in the future,» says Early Stage Researcher Minna Oksanen, the lead author of the study.
Because MVS are not susceptible to antibiotics, the researchers speculate that instead «new drugs that prevent vesicle production may -LSB-...] be a viable therapeutic option to prevent GBS mediated preterm birth.»
«Our study on the TACC3 - chTOG interaction will allow cellular biologists and researchers on microtubule dynamics to better understand how microtubule assembly is regulated during cellular division,» says Montoya, and he anticipates that «it could also help in developing new anti-microtubule drugs, providing more effective therapeutic options in cancer treatment.»
Scientists have suggested that such embryonic stem cells could be used for learning about genetic diseases, testing new drugs on cells grown in the lab, or growing healthy cells for therapeutic transplantation.
Indeed, this study shows that the therapeutic efficacy of a new drug that is currently in clinical trial depends on Sestrin1.
In a new study, published online June 6 in Nature, researchers at University of California San Diego School of Medicine and Moores Cancer Center, together with colleagues at Keio University, the University of Nebraska and Ionis Pharmaceuticals describe an innovative new model that not only allowed them to track drug resistance in vivo, but also revealed a new therapeutic target, which early testing suggests could provide a strategy to arrest pancreatic cancer growth.
Knowing that Notch governs vessel permeability makes it a candidate for new drugs to treat cardiovascular diseases as well, and the team is also investigating the TMD as a potential therapeutic agent itself, as cell models that were exposed to leak - inducing inflammation displayed a dramatic reduction in leakage when they were engineered to express the TMD.
Professor Andrew Lotery, who led the Southampton contribution, hopes the findings may help improve the understanding of the biological processes that lead to AMD and identify new therapeutic targets for potential drug development.
«Targeting this inflammatory pathway with drugs or antibodies could be a new therapeutic strategy to treat worm infections and the associated pathology,» said Meera Nair, an assistant professor of biomedical sciences in the UC Riverside School of Medicine, whose laboratory made the discovery.
A $ 1.7 million drug discovery effort to identify molecular and genetic risk factors and new therapeutic targets for cognitive decline and Alzheimer's disease, based on data from the Religious Order Study and the Rush Memory and Aging Project.
New research findings published in the February 2016 issue of the Journal of Leukocyte Biology, suggest that a new therapeutic strategy for HIV may already be available by repurposing an existing prescription drNew research findings published in the February 2016 issue of the Journal of Leukocyte Biology, suggest that a new therapeutic strategy for HIV may already be available by repurposing an existing prescription drnew therapeutic strategy for HIV may already be available by repurposing an existing prescription drug.
This could open the door to a whole range of new dietary strategies, foods or drugs that might play a role in cancer suppression or therapeutic control.»
Due to the lack of any valid new therapeutic alternative, an older antibiotic, colistin, has become the last resort drug for managing infections caused by these superbugs.
«A better understanding of the brain region and cell type - specific binding targets of Hnrnph1 will tell us more about the function of this gene and possibly identify new therapeutic strategies for minimizing risk and treating psychostimulant addiction — a disorder for which there is currently no FDA - approved drug,» explained corresponding author Camron Bryant, PhD, assistant professor of Pharmacology and Experimental Therapeutics & Psychiatry at BUSM.
The team also discovered new pockets in the HNF - 4α protein that could be targeted with therapeutic drugs.
«Our findings suggest new ways of tackling the still - difficult task of working out which patients should receive which drug and how drugs should be combined to maximize therapeutic benefit,» said senior study author Peter Sorger, the Otto Krayer Professor of Systems Pharmacology and director of the Harvard Program in Therapeutic Science and the Laboratory of Systems Pharmacology at Harvard Meditherapeutic benefit,» said senior study author Peter Sorger, the Otto Krayer Professor of Systems Pharmacology and director of the Harvard Program in Therapeutic Science and the Laboratory of Systems Pharmacology at Harvard MediTherapeutic Science and the Laboratory of Systems Pharmacology at Harvard Medical School.
In a new paper published this week in PNAS, researchers describe a potential new class of anti-cancer drugs that inhibit two or more molecular targets at once, maximizing therapeutic efficiency and sa...
«Our new structure of the serotonin receptor in the resting state has the potential to serve as a structural blueprint to drive targeted drug design and better therapeutic strategies.»
Research teams are also developing ways to innovate the early drug - discovery process, including pioneering methods to rapidly identify drug targets and test them on laboratory models and finding and testing new therapeutic possibilities for already FDA - approved drugs.
«To date, neither antiviral drugs nor vaccines are approved for clinical use against human parainfluenza virus, which reinforces the urgent need for new therapeutic discovery strategies.
The identification of genes that are synthetically lethal in β - catenin - activated cancer cells would provide new targets for therapeutic drug design.
«This project could lead to new therapeutic targets and more effective and safer drugs for the disease.»