Sentences with phrase «new therapeutic targets»
«This makes it important to identify new therapeutic targets for the development of effective treatments,» the investigators conclude.
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Understanding these mechanisms could provide new therapeutic targets and novel approaches for virtually every type of human cancer.
This technology helps researchers connect mutations in the so - called genomic «dark matter» with the genes they affect, potentially revealing new therapeutic targets for genetic disorders.
The authors conclude that these genes may represent new therapeutic targets for HD.
To this end, he has identified and is pursuing new therapeutic targets and experimental strategies to block disease - causing processes and to make the brain more resistant to disease.
In addition, these findings may expand the number of possible new therapeutic targets for this disease.
His research aims to reveal cellular interactions that could become new therapeutic targets to treat type 2 diabetes.
This work could also improve the early diagnosis of lung cancer and lead to the identification of new therapeutic targets.
Thus there is a pressing need for basic studies to reveal new therapeutic targets.
Professor Andrew Lotery, who led the Southampton contribution, hopes the findings may help improve the understanding of the biological processes that lead to AMD and identify new therapeutic targets for potential drug development.
«PI3K protein: Potential new therapeutic target in pancreatic neuroendocrine tumors.»
«Mitochondrial metabolism linked to acute kidney injury: PGC1 alpha works through NAD «aging molecule» to guard against stress; research offers new therapeutic target for acute kidney injury.»
Our work suggests that studying PI (3,4) P2 - regulated processes may reveal why PTEN is such a powerful tumour suppressor and may also help us to identify new therapeutic targets in PTEN - mutated cancers.»
His work has uncovered new therapeutic targets aimed at preventing the accumulation of beta - amyloid (Aβ), the primary neurotoxic agent in AD.
«It would be amazing if we could use these differences in collagen patterns to help discover new therapeutic targets for this devastating disease.»
This novel model also has the potential to help find new therapeutic targets within the immune system and to help design vaccines for patients who do not typically respond to immunotherapy.
In their pilot study, they are gathering data on three potential SCC genes to see if these genes could be used as new therapeutic targets or as early cancer markers.
«Since neurotrophins and their receptors control the communication between the brain and peripheral organs, they could be new therapeutic targets with implications in both metabolic and neurologic diseases.»
Future investigations on the postsynaptic role of p - tau will be necessary to understand its toxic effects and provide insights into new therapeutic targets for maintaining spine integrity, highlighting the importance of tau toxicity as well as the impact of sex on tau - pathology.
Improving our understanding of the relationship between changes in the retinal microvasculature, RNFL and lamina cribrosa in the pathophysiology of glaucoma can inform the development of new therapeutic targets designed to slow the microvasculature changes as a new non-IOP lowering approach to glaucoma therapy.
«This study opens an entirely new area of discovery for many aspects of cell biology and biomedical research — how cancer cells metastasize, for example — and provides many new therapeutic targets,» said senior author Jack Dixon, PhD, professor in the UC San Diego School of Medicine and associate vice chancellor of Scientific Affairs.
He envisions a global initiative worth about $ 200 million a year — half from private money and half from public and charitable sources — that would focus solely on new therapeutic targets.
«This is relevant to a variety of diseases associated with chronic inflammation, including cancer, and could yield new therapeutic targets.»
«The induced pluripotent stem cells we used in this study proved to be extremely useful in disease modelling, and they could offer an excellent platform for drug discovery and testing new therapeutic targets for Alzheimer's disease in the future,» says Early Stage Researcher Minna Oksanen, the lead author of the study.
Our findings suggest that soluble Cd14 could be an interesting new therapeutic target for future clinical research.»
«With TEK, we know exactly what's going wrong, which means we've identified a pathway that could be a great new therapeutic target for severe glaucoma and even more common forms of the disease.»
Identifying these dependencies provides opportunities for scientists to gain deeper insight into cancer biology and determine new therapeutic targets.
A cold «sensor» which triggers the skin's vascular response to the cold could represent an exciting new therapeutic target for the treatment of frostbite and hypothermia, according to scientists at King's College London.
Our collaborations with industry, government agencies, and academia focus on developing new disease models, elucidating new therapeutic targets to develop treatments, safety testing on new chemical entities, enabling better and safer design of new consumer products, and new applications in personalized healthcare.
The focused, long - term effort of the Catalyst For a Cure continues to discover new mechanisms involved in the loss of retinal neurons which could open new therapeutic targets — and serves as a national role model for effective research.
COPD is now considered to be a disease of accelerated ageing of the lung, and understanding the molecular signalling pathways involved in the ageing process (cellular senescence) has identified new therapeutic targets [37].
Kilian's main research interests comprise the functional exploration of cellular signaling networks by the development of specific chemical probes and chemical biology approaches apt to identify new therapeutic targets relevant for the treatment of human disease.
That year also marked their development of three new hypotheses for how glaucoma is initiated and where new therapeutic targets may be found.
We thereby want to understand the underlying mechanisms to develop new therapeutic targets (including new concepts of targets).
«MicroRNA that blocks bone destruction could offer new therapeutic target for osteoporosis.»
An international study led by researchers at Monash University» Biomedicine Discovery Institute (BDI) has shone light on the way the Hepatitis C Virus (HCV) hijacks the communication systems in the host cells it infects, uncovering potential new therapeutic targets for the disease.
Her research group focuses on diagnostic, prognostic and predictive biomarkers; discovering new therapeutic targets; cancer cells communication via exosomes, microvesicles and CTCs; elucidating and circumventing resistance to targets agents and classical chemotherapy; associations between obesity, metabolic syndrome and cancer.
Our aim is to highlight the genetic networks that can impact on DM1 biomarkers to provide new therapeutic targets for treatments by chemical compounds.
Understanding the role of glial cells in glaucoma as well as what happens to the optic nerve where the retinal nerve axons leave the eye may present new therapeutic targets and even potential biomarkers of glaucoma.
These two histones thus have a key role of epigenetic silencing of tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets.
«Novel imaging model helps reveal new therapeutic target for pancreatic cancer: Antisense treatment in preclinical models shows effectiveness against deadly tumors.»
«This perspective will offer us a window into new therapeutic targets for these diseases.»
In addition to generating data, an important goal of the AMP T2D consortium is to make these data accessible via a knowledge portal, using genetic and phenotypic data generated from type 2 diabetics and controls across multiple populations in order to bring forth discoveries in the genetic architecture of type 2 diabetes and to facilitate the development of new therapeutic targets for treating this disease.
Researchers from the Wellcome Trust Sanger Institute and their collaborators have adapted a CRISPR gene editing technique and used it to find new therapeutic targets for acute myeloid leukemia (AML).
«Researchers identify new therapeutic target for cancer.»
«We think this development will help other scientists better utilize open data, hopefully leading to the discovery of new therapeutic targets for disease,» says first author Andra Waagmeester, PhD, formerly a researcher at Maastricht University and now CEO of the start - up company Micelio.