Finally, the study suggests
new tumorigenic and cellular functions of BAP1 and shows for the first time the interest of studying the proteome as readout of BAP1 inactivation.
Not exact matches
The prevailing theory of cancer progression — that it's driven by the accumulation of genetic mutations that increase
tumorigenic «fitness» — holds true for the early stages of cancer progression, but metastases seem to find
new ways to increase their fitness, McDonald said.
Consequently, the use of such a marker suggests a
new strategy to screen novel therapeutics in a rapid and efficient manner directly in the
tumorigenic mouse.
«The
new study further substantiates the
tumorigenic role of Gfi1 in medulloblastoma, and reveals that this oncogene is normally repressed by Ezh2.