Scientific programs include: human genomic sequencing and analysis, synthetic genomics and exploration of
new vaccines using this technology, and environmental and single cell genomics to explore the vast unseen world of microbes living in the human body, the ocean, soil and air.
Not exact matches
For example, a
new Ebola
vaccine was just developed, and its creation required the
use of monkeys.
Today all
new viral strains
used to make
vaccines must be generated by specific artificial genetic modifications rather than by «breeding,» so as to prevent possible reversion back to a virulent form.
The manufacturer of the sole dengue
vaccine on the market says a
new study shows that it should only be
used in people who have had a previous infection from the mosquito - borne virus.
Together with researchers at the CNRS, the group has demonstrated the efficacy of RNA - based
vaccines produced
using the
new method against plant virus infections.
No rapid, reliable test for previous dengue infection is available, so the
new guidelines mean that the
vaccine can't be widely
used; that could lead the company to stop making the
vaccine.
Texas researchers are planning to
use a combination of tobacco plants and podlike laboratories to speed the production of
new vaccines
And a
new analysis of the STEP trial, published last November in Proceedings of the National Academy of Sciences USA, provides a warning that the very vectors (adenoviruses, which are also employed in other
vaccine development work)
used to distribute the inactive HIV strains can actually make the immune system more vulnerable to infection by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.
In the
new study, researchers at the NIAID
used a virus - like particle
vaccine cocktail that expressed a handful of different subtypes of a key surface protein of the influenza virus: hemagglutinin H1, H3, H5 and H7.
Another possible application for the
new machine is generating peptides that could be
used as personalized cancer
vaccines targeting unique proteins found in individual patients» tumors.
Researchers have made headway in understanding the H5N1 virus; they have created
new vaccines and are looking into other possible treatments, such as
using antibodies from survivors.
At Kaiser Permanente Northern California, which conducted the study, the first
use of the
new DTaP was in the
vaccine's fifth booster shot in 1991, followed by its
use for the fourth booster the next year.
The US decides to
use its standard formulation for flu
vaccine, so no
new regulatory tests will be needed.
Some have argued that the switch from the older cellular
vaccine, which
uses whole bacteria, to the
newer acellular
vaccine, which was introduced in 1997 and contains components of the bacteria, resulted in weaker immunity among children and teenagers.
To create a
new dengue virus
vaccine, Stefan Metz, Shaomin Tian in the laboratories of Aravinda de Silva, Chris Luft and Joe DeSimone at the University of Carolina, Chapel Hill, USA designed nanoparticles of various shapes and sizes
using Particle Replication in Non-wetting Template (PRINT) technology.
In addition,
vaccine - makers that
use eggs can not begin developing
new vaccines that target
new virus strains until the U.S. Centers for Disease Control and Prevention (CDC) creates a live - virus reference strain for these companies to work with, a process that could take several weeks.
«Key benefits of large - scale
use of universal over conventional flu
vaccines: Mathematical model reveals potential effects of
new vaccines that target multiple flu strains.»
Vaccination rates for a critical booster shot tripled after clinics began
using electronic prompts alerting them of patients needing the Tdap
vaccine that protects against tetanus, diptheria, and whooping cough, according to a
new study from the University of Michigan Health System.
Using the
new measure would almost certainly help improve the situation, but it's not the only
vaccine metric in need of a revamp.
«What is
new about this is we have developed a
vaccine against dust - mite allergens that hasn't been
used before,» says Aliasger Salem, professor in pharmaceutical sciences at the UI and a corresponding author on the paper.
Yet
vaccine companies have little incentive to build expensive
new factories to make a product that will mostly be
used once wild polio is gone — maybe in three years, maybe 10 — and then only for another five years or so.
A
new approach to the live flu
vaccine would be particularly advantageous right now after the Centers for Disease Control and Prevention stopped recommending
use of the live attenuate flu
vaccine, FluMist ® earlier this year.
Some
newer vaccine candidates
use harmless viruses such as modified adenoviruses to deliver genes that encode immunizing viral proteins.
By contrast, the
new Zika candidate
vaccine uses tiny strands of RNA that hold the genetic codes for making viral proteins.
The
new candidate
vaccine is the first to show such potent and long - lasting protection without the
use of a live virus.
5) Explore
new vaccine technologies — Longer term, we need to evaluate
new ways to vaccinate wild carnivores for distemper, in situations wherein
use of an injectable
vaccine is not feasible by hand or by dart.
And a
new analysis of the stopped STEP trial, published online Monday in Proceedings in the National Academy of Sciences, provides a warning that the very vectors (adenoviruses, which are also employed in other
vaccine development)
used to distribute the inactive HIV strains can actually prime the immune system to be infected by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.
For the study, the research team
used a
new method in which mice were immunized with a model
vaccine (called an antigen) that is given orally.
He worries that a live
vaccine that
uses Vibrio strains whose virulence genes have been removed may still be capable of getting
new virulence genes through its integron.
This
new study shows that it may be important to
use these
vaccines for a specific population.
In 1955, 13 years too late for Edgerton, the United States began the widespread
use of a
new polio
vaccine that would eventually prevent millions of children from contracting polio and suffering its consequences.
«
New malaria
vaccine effective in clinical trial: Researchers achieve protection of up to 100 percent
using fully viable malaria parasites.»
New, so - called oil - in - water adjuvants could make the
vaccines more potent and might stretch the limited
vaccine supply, but the compounds, already in
use in Europe, have not received FDA approval.
Ebola
vaccine for chimps works but may never be
used Chimpanzees threatened by an Ebola outbreak could be protected by a
new vaccine, but cuts in chimp research may stymie its development
«You have to have a transition period» in which both oral and inactivated
vaccines are
used, «because if you stop cold turkey you're going to have outbreaks», says Vincent Racaniello, a virologist at Columbia University in
New York City.
The
new technique, pioneered by Wilson and fellow researchers at the Emory University School of Medicine in Atlanta, saves time by
using antibodies produced by so - called B cells (white blood cells that produce and then ferry them to infection sites to battle invading germs) in response to
vaccines instead of to actual infections.
The ability to design
new protein nanostructures could have useful implications in targeted delivery of drugs, in
vaccine development and in plasmonics — manipulating electromagnetic signals to guide light diffraction for information technologies, energy production or other
uses.
The bacterium that causes whooping cough, Bordetella pertussis, has changed in Australia — most likely in response to the
vaccine used to prevent the disease — with a possible reduced effectiveness of the
vaccine as a result, a
new study shows.
Kennedy has continued to
use his name to promote the idea, and in recent months
vaccine skeptics have called for a
new «
vaccine safety» commission with Kennedy at its head.
The research proposes a
new model of evolutionary games with a feedback loop in which changes to the resource — whether it be water supplies, pastureland, antibiotics, or
vaccine use — change the incentives for people to take action in their own interests.
People's willingness to
use a Zika
vaccine when it's available will be influenced by how they weigh the risks associated with the disease and the
vaccine, but also by their misconceptions about other
vaccines, a
new study has found.
Now researchers have
used a
new strategy to develop a
vaccine that protects mice from multiple variants of the Strep B bug, which kills around 100 newborns in the United States each year.
In addition to the expanded
use of ARVs in
new modalities such as pre-exposure prophylaxis and microbicides [1], this includes commensal microbicides [2], gene therapies [3], [4] and
vaccines [5], [6], [7].
The
vaccines used by commercial fish farmers are not protecting fish from disease, according to a
new study.
Department researchers are developing
new vaccines against these viruses and in identifying small molecular weight compounds for
use as antivirals.
After constructing the first synthetic bacterial cell and the first minimal bacterial cell, JCVI scientists are
using the groundbreaking techniques
used in these milestones to construct synthetic flu
vaccines, develop unique
new sources of insulin, and more efficient means to produce algae - based biofuels.
The current epizootic in the Far East caused by avian influenza virus A (H5N1) has led to real concern about the possibility of a
new pandemic of influenza.12 Technological innovation, such as the
use of
new vaccines delivered by the intradermal route, offers great promise to change and improve on current immunization strategies.
Already, the Pirbright team has
used the
new vaccine to give a sample of British cattle complete immunity to lethal strains of LSD and rinderpest.
«To date, neither antiviral drugs nor
vaccines are approved for clinical
use against human parainfluenza virus, which reinforces the urgent need for
new therapeutic discovery strategies.
These same models are
used to develop
new anti-cancer
vaccines based on long peptide or DNA vaccination targeting the antigen to antigen presenting cells.