German scientists say that they need access to
newer stem cell lines to compete and collaborate internationally.
The year's most prominent science issue, federal support of embryonic stem cell research, is so controversial that the sons of Ronald Reagan gave dueling speeches at the opposing party conventions; Michael Reagan backs President George W. Bush's policies, including the ban on funding for research on
new stem cell lines, while Ron supports Senator John Kerry's promise to lift restrictions.
In May 2006, Eggan's lab received approval from Harvard to seek healthy human eggs from female donors, a first step toward using research cloning to create
new stem cell lines.
The finding potentially paves the way for scores of labs to generate
new stem cell lines without cloned embryos, which had long been considered the only realistic way of making human stem cells in the short run.
For now,
the new stem cell lines UC Berkeley researchers have created will help scientists understand the first molecular decisions made in the early embryo.
A new stem cell line with the mutation for fragile X syndrome may help uncover the mechanism behind the debilitating disorder
For more on human embryonic stem cells, see Teisha Rowland's «All Things Stem Cell post on «Induced Pluripotent Stem Cells:
A New Stem Cell Line with a Long History,» The National Institute of Health's Stem Cell FAQs, or, for a visual explanation of terms used, see All Things Stem Cell's Visual Stem Cell Glossary.
Obama called upon the National Institutes of Health to set up rigorous guidelines to ensure that
new stem cells lines were derived by ethical practices.
«Over a thousand lines have been derived since August 9, 2001, many with attributes beneficial to medical research,» says Daley, whose own lab has derived 18
new stem cell lines.
On August 23, 2010, Judge Royce Lamberth of the United States District Court for the District of Columbia issued a preliminary injunction against the National Institutes of Health (NIH) guidelines allowing federal dollars to fund projects in which embryos were destroyed to derive
new stem cell lines.
Others were disappointed that the White House had effectively prohibited the creation of
new stem cell lines using federal funding.
However, some consider human embryonic stem cell research controversial because, in some cases,
the new stem cell lines are derived frozen human embryos that have been donated for research.
He was the principal investigator on the project that yielded 17
new stem cell lines, paid for completely with private funds.
Not exact matches
In all likelihood, soon after he is sworn in, federal dollars will start flowing toward research on
new embryonic
stem -
cell lines, bringing with it
new battles to fight.
Not surprisingly, President Obama received high marks from the journal, largely because his response to the question of whether he would lift Bush's ban on the federal funding of
new embryonic
stem -
cell lines is in
line with the view of most in the scientific community.
In fact, the latest research in epigenetics,
stem cells, and the developmental origins of health and disease is unlocking a whole
new line of understanding of what breastmilk contains and its role in development.
Hamilton announced the
newest organ - on - chip innovation, which recreates an intestinal
lining using patient - derived
stem cells, created through a partnership between Emulate and Cedars - Sinai Board of Governors Regenerative Medicine Institute.
Wayne Hellstrom of Tulane University in
New Orleans, Louisiana, and colleagues, extracted
stem cells from fat and placed them onto layers of tissue taken from the
lining of pig intestine.
In May 2005, Hwang and his colleagues reported that it had produced 11
new human embryonic
stem (ES)
cell lines that carried the genetic signature of patients with diabetes, spinal cord injury, or a genetic blood disorder (Science, 20 May, p. 1096).
The laboratory process, described in the journal Scientific Reports, entails genetically modifying a
line of human embryonic
stem cells to become fluorescent upon their differentiation to retinal ganglion
cells, and then using that
cell line for development of
new differentiation methods and characterization of the resulting
cells.
Intestinal
stem cells are particularly important because a
new intestinal
lining is generated about every 4 - 5 days.
In 2001, after President Bush limited federally funded research to 69 existing embryonic
stem cell lines, Melton launched a private fund - raising crusade and developed 17
new lines that are now available to any reputable
stem cell researcher.
Last January, the House of Representatives voted, 253 to 174, to pass a bill, H.R. 3, that would allow researchers to use leftover embryos from in vitro fertilization (IVF) clinics to create
new lines of embryonic
stem cells, and in April, the Senate passed its version of the bill.
British newspapers reported this weekend that Ian Wilmut, the University of Edinburgh biologist who led the team that in 1997 cloned Dolly the sheep, is getting out of the cloning business in light of the
new findings, which seem to offer researchers a likely
new source of
stem cell lines for basic research that could one day lead to
new treatments and perhaps cures for spinal injuries, diabetes and debilitating disorders such as multiple sclerosis and Parkinson's disease.
In a
new study published in Scientific Reports, Tokyo Medical and Dental University (TMDU)- led researchers investigated photodynamic detection of cancer
stem cells in a glioma
cell line, a model of a highly aggressive type of brain cancer.
In the face of these setbacks, many scientists have focused on
new methods of creating
stem cell lines without destroying embryos.
Mindful of public sensitivities, Daley opted to pursue experiments using what he considers the least controversial human materials to create
new nonpresidential
stem cell lines — poor quality embryos and oocytes that, in his words, «otherwise would have been disposed of as medical waste.»
Salk scientists and colleagues have proposed
new molecular criteria for judging just how close any
line of laboratory - generated
stem cells comes to mimicking embryonic
cells seen in the very earliest stages of human development, known as naïve
stem cells.
A bill that would allow federal funding for derivation of
new lines of human embryonic
stem (ES)
cells passed the U.S. House of Representatives yesterday 238 to 194 after more than four hours of debate.
With so much work needed in studying the nature of
stem cells and using them to study disease processes, therapies based on ES
cells seem very far down the
line, noted Lorenz Studer of Memorial Sloan - Kettering Cancer Center in
New York, who pointed out that so far there have only been two published papers on therapeutic cloning, both of them in mice.
According to a
new analysis, the
cell line they created represented the first example of parthenogenetic human embryonic
stem (ES)
cells.
For while the
new NIH guidelines explicitly permit funding for research on
stem cell lines in which human embryos have already been destroyed, they also explicitly forbid funding for research on
stem cell lines that have been produced by SCNT (see section V. part B).
The goal of this protocol (written in French) is to describe the steps and quality controls to prepare
new stable murine embryonic
stem cells lines: ① either from wild type mouse embryos to introduce a mutation by genetic targeting or homologous recombination to get a genetically modified mouse
line ② or from genetically modified mouse embryos with two aims:
In effect, the
new guidelines provide an incentive to private research entities to obtain so - called «leftover» embryos from fertility clinics and derive
stem cell lines from them in order to obtain NIH research dollars to study the derived
lines.
What Collins does not say, however, is that the
new NIH guidelines also allow for federal funds to be used in studying
new human embryonic
stem cell lines that are created (by private entities, of course) beyond the 700 currently in existence.
The
new NIH guidelines do not permit the use of federal funds for creating
new human embryonic
stem cell lines.
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For the first time since the linkurl: National Institutes of Health; http://www.nih.gov/ released its
new guidelines for the derivation of human embryonic
stem cell (hESC)
lines last summer, a
line approved under the Bush administration has been recommended for inclusion into the growing federal registry of
lines eligible for federal funding.
All the hES and human induced pluripotent
stem cell lines were confirmed to be genetically stable and pluripotent in in vivo and in vitro assays after extensive culturing on the
new substrata.
Using pre-implantation genetic diagnosis derived human embryonic
stem cell lines (hES) or human induced pluripotent
stem cells carrying the causal mutation for neuro - muscular diseases, our objective is double: identify
new physiopathogical mechanisms and develop
new therapeutic strategies.
Further, as people get older, their
stem cells also tend to lose their ability to differentiate into
new cell lines, including much - needed immune
cells.
Labs that derive
new human embryonic
stem cell lines are few, partly because they can not get financial support from federal sources.
The self - renewable capacity of these
cells, their ability to differentiate into several tissue progenitors (neural, mesenchymal
stem cells...), and the possibility to work with mutated
cell lines define human
stem cells as a good basis for screening compounds libraries in order to discover
new potential drugs for monogenic diseases.
At a ceremony in the East Room of the White House, the president said he couldn't accept a bill that would underwrite research using
new lines of embryonic
stem cells — even though that research could find cures for diabetes, Parkinson's, Alzheimer's, and other illnesses.
Advanced reproductive techniques such as artificial insemination, culturing of primordial germ
cells for germ -
line transmission,
stem cell embryogenesis, and cloning offer an array of
new ways to expand and even infuse lost and
new genetic variability into at - risk wildlife populations.
A team led by Young - sup Yoon, MD, PhD developed a
new method for generating endothelial
cells, which make up the
lining of blood vessels, from human induced pluripotent
stem cells..
Scientists from the Research Department of Cryo - Save Group NV together with the University of Cologne (DE) have developed a
new scientifically validated method to collect adult mesenchymal
stem cells («MSCs») from the
lining of umbilical cord tissue.
In addition, three California - based ALS research labs have joined forces to form the Neuro Collaborative, which will create induced pluripotent
stem (iPS)
cell lines from ALS patients that can be used to screen for
new drugs and will be shared with the other groups.
Newer lines of research are focused on understanding cancer
stem (CSC)
cell biology so that therapies targeting them can be developed.