Sentences with phrase «next generation drugs»

Medicine and a host of next generation drugs, procedures, and gene therapies rely HEAVILY on evolutionary theory in their development and application.

I can assure you, NO» next generation drugs, procedures and gene therapies» rely on macro evolution.

The next generation drug in the taxane family, cabazitaxel, was approved in 2010, but only for patients whose cancer no longer responded to hormone therapy or docetaxel treatment.

The SSPC leads the way for next generation drug manufacture and spans the entire pharmaceutical production chain from synthesis of the molecule, to the isolation of the material, and formulation of the medicine.

Not exact matches

How can conglomerate drug companies organize R&D to develop next - generation blockbuster drugs?

The ongoing American Heart Association (AHA) meeting in New Orleans is producing a deluge of data — including some promising prospects for a class of next - generation cholesterol drugs that have been slow to take off so far in the U.S. So - called PCSK9 inhibitors have shown tremendous efficacy in lowering LDL - C, or «bad» cholesterol.

Nor can every product be built for prices the average Joe is willing to risk (for example, the next Tesla automobile), or be brought to market for less than $ 10 million (e.g., the next generation of cholesterol drugs).

At the same time, the next generation of multi-billion-dollar drugs takes time to build the billions in sales needed to make the best - seller list — but can be expected to do so starting next year.

Sierra Oncology, Inc., a clinical stage drug development company focused on advancing next - generation DNA damage response therapeutics for the treatment of patients with cancer, went public near $ 29 in July 2015, then began a downtrend that continued through a June 2017 all - time low of $ 1.10.

Graham Lumsden, chief executive of Motif Bio Plc (LON: MTFB), caught up with Proactive's Andrew Scott as the drug developer gears up for the commercial launch of its next - generation antibiotic.

«We have developed a drug candidate, a next - generation biologic medical product, and are now publishing the fantastic results from the preclinical part where wound healing was strongly accelerated in mice,» says Mia Phillipson, Professor at the Department of Medical Cell Biology, Division of Integrative Physiology, Uppsala University.

Male rats exposed to cocaine may pass epigenetic changes on to their male offspring, thereby altering the next generation's response to the drug.

Celgene scientist Patrick Hagner develops next - generation IMiD therapies, including drug candidate CC122.

This achievement will also contribute to accelerating the research applications of RNAi such as to the development of RNA - based next - generation drugs, for example as gene therapy to suppress the production of a disease - causing protein.

The researchers tested two anti-CK2 drugs for their ability to stimulate the production of new brown fat in mice: a new small - molecule CK2 - blocker called silmitasertib (CX - 4945), which is already in clinical trials as a cancer therapeutic; and a more precise next - generation antisense oligonucleotide (ASO) drug developed in collaboration with Isis Pharmaceuticals, which eliminates CK2 by blocking the RNA instructions cells use to produce it.

The researchers are now examining whether CK2 - inhibitors can effectively reduce obesity as well as prevent it, and whether they can be used alongside next - generation drugs that mimic the effects of cold to trigger brown fat to burn energy in humans.

It also provides valuable information that may assist researchers in the development of genetic tests based on next generation sequencing, and in the initiation of large intervention trials to assess the efficacy of orphan drugs.

«This allows us to make small changes to these antibiotics such that the kinases can no longer interact with these drugs, which will make the next - generation antibiotics less susceptible to resistance by superbugs.»

But if researchers understand the changes that make cancer cells resistant to a drug, they can work to develop a next - generation therapy.

«If knocking out this other hydrogenase also drastically reduces long - term survival, the enzyme might end up being an excellent next - generation drug target in latent TB infections, which around one - third of the world's population suffer.

Given the role of Msi in promoting aggressive disease, the investigators partnered with Robert MacLeod PhD, vice-president of oncology drug discovery at Ionis Pharmaceuticals, to develop next - generation antisense oligonucleotide (ASO) inhibitors against Msi.

The ultimate goal is to precisely understand the mechanisms of checkpoint blockade effectiveness and bring next generation, sustainable immunotherapies to even more patients, perhaps using by using epigenetic drugs in combination with checkpoint blockade to allow epigenetic reprogramming of exhausted T cells into durable and functional memory T cells.

«This could be very important for the next generation of space missions to the Moon and Mars and possibly have repercussions on the development of drugs on Earth.»

This mechanism includes potential targets for next - generation drug discovery efforts to treat metabolic diseases including diabetes and obesity.

siRNNs represent a transformational next - generation RNAi drug.

This mechanism includes potential targets for next - generation drug discovery efforts to treat met... more

Our PDX models and other next - generation cancer modeling platforms allow you to address critical questions in oncology research, such as unexplained drug resistance, drug efficacy, genomic heterogeneity in solid tumor, and the role of the immune system in drug response.

take a lead in developing the next generation of cancer cell lines and use cell lines to systematically explore in vitro sensitivity to large numbers of anticancer drugs and drug combinations in order to inform choice of cancer types for early drug trials.

Conventional immune analysis technologies fail to provide the detailed insights that are needed to create the next generation of antibody drugs.

«We have developed a drug candidate, a next - generation biologic medical product, and are now publishing the fantastic results from the preclinical part where wound healing was strongly accelerated in mice,» says Mia Phillipson.

This discovery opens the path for industry, such as ICT and pharmaceutical, to cheaply print a host of electronic devices from solar cells to LEDs with applications from interactive smart food and drug labels to next - generation banknote security and e-passports.

Melov thinks that, given the resources, BAIT could handle up to 50 or 60 compounds, providing a next - generation resource for drug development.

At the same time, we retain a strong commitment to investigating the cancer cell itself, finding new opportunities in targeting in oncogenic and tumor suppressive pathways, as well as in next - generation antibody - drug conjugates.

Knowing how ISRIB stabilizes elF2B may help Calico researchers and other collaborators tailor even more effective next - generation drugs against neurodegeneration and traumatic brain injury.

SAN DIEGO, March 28, 2017 (GLOBE NEWSWIRE)-- Invivoscribe ® Technologies Inc., a global company with decades of experience providing internationally standardized clonality and biomarker testing solutions for the fields of oncology, personalized molecular diagnostics ®, and personalized molecular medicine ®, reports that its next - generation sequencing (NGS) LymphoTrack ® Assay kits are being used by its LabPMM ® clinical laboratories, pharmaceutical partners, and cancer centers to identify and monitor chimeric antigen receptor T - cells (CAR - T) and engineered T - cell receptors in peripheral blood of subjects in support of immuno - therapeutic drug development and treatment regimen development for both hematologic and solid tumors.

De Novo Assembly of Human Herpes Virus Type 1 (HHV - 1) Genome, Mining of Non-Canonical Structures and Detection of Novel Drug - Resistance Mutations Using Short - and Long - Read Next Generation Sequencing Technologies

In a second - floor lab at the USC Keck School of Medicine (School of Pharmacy), Luis Arechiga is testing compounds in search of the next generation of HIV drugs.

Ce - Pim will work to facilitate the seamless integration of methodology into the next generation of implementation research on drug use and sexual risk behavior, and develop a new hybridized form of implementation research by integrating methods within the practice of prevention science and implementation science at the federal, state, county, and local levels.

This drug does not kill the adult dog fleas on your pet, but it does break the flea life cycle by preventing hatching of the next generation of flea eggs Consult your veterinarian for a recommendation on what would work best for your pet.

The next generation of gabapentin, a drug called pregabalin, lasts longer (almost twice as long) and appears to be more potent.

That being said, I do believe that Messenger Kids, for all its security benefits, will be used as a gateway drug to entice the next generation of Facebook users.

And it leads to criminality, and drug addiction, and chronic illness, and people going to prison, and repetition of the trauma on the next generation.