Sentences with phrase «nicotinic acetylcholine»

This disease is caused by an inability of the certain nerve receptors (nicotinic acetylcholine receptors (AChRs) to function properly.

Spinosad is a derivative of macrolide antibiotics Spinosad attacks the nervous system of the flea acting on the nicotinic acetylcholine receptors, there is no interaction with other insecticides.

These latter compounds are neuroactive metabolites that act on N - methyl - D - aspartate (NMDA) and alpha 7 nicotinic acetylcholine receptors (nAChR) in the CNS and enteric nervous system (ENS).

Antidepressant - like Activity of AMOP - H - OH («SAZETIDINE - A») in the Forced Swim TSest is Mediated by High Affinity Nicotinic Acetylcholine Receptors.

There are many different types of nicotinic acetylcholine receptors, performing various roles throughout the body.

Yu L.F, Tuckmantel W, Eaton J.B, Caldarone B, Fedolak A, Hanania T, Brunner D, Lukas R.J, Kozikowski A.P. Identification of Novel alpha4 beta2 - Nicotinic Acetylcholine Receptor (nAChR) Agonists Based on an Isoxazole Ether Scaffold that Demonstrate Antidepressant - like Activity, Journal of medicinal chemistry.

Synaptic and extrasynaptic distribution of two distinct populations of nicotinic acetylcholine receptor clusters in the frog cardiac ganglion.

Perisynaptic surface distribution of multiple classes of nicotinic acetylcholine receptors on neurons in the chicken ciliary ganglion.

Localized expression of Beta2 - containing nicotinic acetylcholine receptors in dopaminergic neurons in mice supports locomotor activating, but not rewarding effects of nicotine Yann Mineur, Yale University, New Haven, Connecticut USA

Yakel's research is directed toward understanding the role of the nicotinic acetylcholine receptor and brain function, as well as how dysfunction in this receptor leads to various neurodegenerative diseases and addiction.

This receptor, known as the nicotinic acetylcholine receptor (nAChR), increases excitability within in the brain's reward centers.

Presynaptic targeting of α4β2 nicotinic acetylcholine receptors is regulated by neurexin - 1β.

Transient cholesterol effects on nicotinic acetylcholine receptor cell - surface mobility.

Presynaptic type III neuregulin1 - ErbB signaling targets α7 nicotinic acetylcholine receptors to axons.

Temporally - and spatially - regulated transcriptional activity of the nicotinic acetylcholine receptor [beta] 4 subunit gene promoter.

Subcellular trafficking, pentameric assembly, and subunit stoichiometry of neuronal nicotinic acetylcholine receptors containing fluorescently labeled α6 and β3 subunits.

Neonicotinoids target nicotinic acetylcholine receptors (nAChRs) in the insect central nervous system.

Abstract Pentameric channel - receptors, including nicotinic acetylcholine, glycine and GABAA receptors, play a key role in fast excitatory and inhibitory transmission in the nervous system and are the target of numerous therapeutic and addictive drugs.

Glutamatergic Synapse Formation is Promoted by α7 - Containing Nicotinic Acetylcholine Receptors.

Distribution and synaptic localization of nicotinic acetylcholine receptors containing a novel α7 subunit isoform in embryonic rat cortical neurons.

Insights into the Structural Determinants Required for High Affinity Binding of Chiral Cyclopropane - Containing Ligands to α4β2 - Nicotinic Acetylcholine Receptors; An Integrated Approach to Behaviorally Active Nicotinic Ligands.

Mapping of presynaptic nicotinic acetylcholine receptors using fluorescence imaging of neuritic calcium.

Rapid activation of presynaptic nicotinic acetylcholine receptors by nerve - released transmitter.

Large clusters of α7 - containing nicotinic acetylcholine receptors on chick spinal cord neurons.

Liu, J., Yu, L. F., Eaton, J. B., Caldarone, B., Cavino, K., Ruiz, C., Terry, M., Fedolak, A., Wang, D., Ghavami, A., Lowe, D. A., Brunner, D., Lukas, R. J., Kozikowski, A. P. Discovery of Isoxazole Analogs of Sazetidine - A as Selective alpha4 beta2 - Nicotinic Acetylcholine Receptor (nAChR) Partial Agonists for the Treatment of Depression, Journal of medicinal chemistry 2011 54, 7280 - 7288

A Gain - of - Function Mutation in the α9 Nicotinic Acetylcholine Receptor Alters Medial Olivocochlear Efferent Short - Term Synaptic Plasticity

Among them is epibatidine, a nicotinic acetylcholine receptor (nAChR) agonist that is lethal at microgram doses.

Poison frogs have evolved mutations in nicotinic acetylcholine receptor genes that confer toxin resistance.

These chemicals work as agonists of insect nicotinic acetylcholine receptors, but their effect on mammals has been unclear.

«We knew that nicotinic acetylcholine receptors, which bind to the virus in muscles, are also found in the brain, and we presumed that virus could also bind to such receptors.

The research revealed that a molecule called a glycoprotein on the surface of the rabies virus can bind to nicotinic acetylcholine receptors in the muscles.

Previous research had shown that nicotine seems to have conflicting effects on different types of nicotinic acetylcholine receptors, proteins on the surface of brain cells that respond to nicotine and the naturally occurring neurotransmitter acetylcholine.

In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater - than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.

Not exact matches

It targets nicotinic 42 receptors (see «Mixed signals»), which normally receive chemical signals from the neurotransmitter acetylcholine.