Sentences with phrase «nicotinic receptors»

Nicotinic receptors are special proteins found in the brain and body that are responsible for receiving a chemical called nicotine. They help transmit signals in our nervous system and are involved in processes like learning, memory, and muscle movement. Full definition
Although this study was looking at the role of nicotinic receptors in disordered mood and the self - medication of mood by smoking, we may be able to extrapolate this for our purposes because it was this one subset of smokers who were more depressed after tryptophan depletion.
But even though TC - 5214 has failed to significantly relieve major depression in a phase III trial and investors are fleeing, some analysts and scientists argue that the setback need not spell the end for the drug, nor for other compounds that act on nicotinic receptors in nerve cells.
Lindstrom and his colleagues inserted genes for human nicotinic receptors into frog eggs and incubated them with levels of nicotine similar to those found in the blood of a human smoker.
The two «frontrunners», according to Dr. Buchanan, are ispronicline (nicotinic receptor partial agonist), and ORG 24448 (modulator of AMPA glutamate receptors).
A better understanding of such receptors, he says, may help researchers more efficiently target nicotinelike drugs in patients with diseases that may involve nicotinic receptors, including Parkinson's disease, Tourette's syndrome, and schizophrenia.
This illustration shows how the rabies virus inhibits nicotinic receptors in the brain, which interferes with communication and induces frenzied behavior.
The nervous system is studded with nicotinic receptors, neurons that help regulate the release of important neurotransmitterssuch as acetylcholine, serotonin, and dopamine.
Anand, who studies the association between nicotinic receptors and central nervous system disorders, was inspired to pursue a model of human neural biology after encountering disappointing results in a rodent study of an experimental autism drug.
He uses various electrophysiological and voltage - sensitive dye recording techniques to study hippocampal excitability and circuits regulated by nicotinic receptor activation to gain insights into disease mechanisms.
The CHRNA5 - CHRNA3 - CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African — Americans and in European — Americans
Heavy smokers can consider taking prescription drugs such as bupropion (an antidepressant) or varenicline (a «nicotinic receptor partial agonist»).
«One of the functions of nicotinic receptors is to moderate the entry of calcium into cells.
His own work with mice «provides converging evidence» that «this variant of the nicotinic receptor doesn't follow the same rules as the others do.»
To some extent, all of these medications, which are approved by the FDA, all target the nicotinic receptor in the brain, and this might not be the optimal strategy for women.
Precisely where these findings will lead drug treatment strategies is unclear, but this work provides insight into the role of nicotinic receptors in the vulnerability to multiple classes of addictive drugs.»
«It raises the possibility that nicotinic receptors may be important targets for the treatment of multiple addictions, not just nicotine.
Objective: To study, at high spatial and temporal resolution, the conformational dynamics of the nicotinic receptors enabling neuronal communication in the brain, which are major therapeutic targets linked to cognition and tobacco dependence.
To understand how nicotine affects nAChR localization, Ashley M. Fox — Loe and colleagues at the University of Kentucky developed sensitive, organelle - specific single - molecule imaging methods to quantify precisely changes in the stoichiometry of nicotinic receptors.
Varenicline stimulates the nicotinic receptors in the brain to help reduce withdrawal symptoms, and also helps reduce the pleasure of smoking if the quitter sneaks a cigarette.
Nicotine sparks the production of dopamine when it binds to the brain's nicotinic receptors; dopamine is associated with pleasure and addiction.
First off, it contains Dinotefuran which is a lot similar in pharmacologic action to Imidacloprid especially in the inhibition of nicotinic receptors in the flea nervous system.
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