Sentences with phrase «nitric oxide signalling»

This is the first study to demonstrate an epigenetic model of nitric oxide signaling that has the potential to «change our fundamental understanding of both nitric oxide biology and epigenetic regulation,» Thomas said.

Background - Nitric oxide signaling plays a key role in regulation of vascular tone and platelet activation.

Using individual - level data from 335,464 participants in the UK Biobank and summary association results from seven large - scale genome wide association studies, we examined the effect of this nitric oxide signaling score on cardiometabolic and other diseases.

Pharmacologic stimulation of nitric oxide signaling may prove useful in the prevention or treatment of cardiovascular disease.

Results - A genetic predisposition to enhanced nitric oxide signaling was associated with reduced risks of coronary heart disease [OR 0.37 95 % CI 0.31, 0.45; p = 5.5 * 10 -LRB--26)-RSB-, peripheral arterial disease (OR 0.42 CI 0.26, 0.68; p = 0.0005) and stroke (OR 0.53 CI 0.37, 0.76; p = 0.0006).

Studies show that nitric oxide signaling and the blood flow increases it stimulates play a central role in nerve cell maintenance, growth and repair.,, Most pertinent to anyone looking to enhance their aptitude for learning, nitric oxide - induced blood flow also makes forming new memories physically possible as it plays a key role in what neurologists call long - term potentiation, a process required for assembling and reinforcing new synaptic connections throughout the entire cerebral cortex, striatum, and hippocampus.

Studies show that nitric oxide signaling and the blood flow increases it stimulates play a central role in nerve cell maintenance, growth and repair.

The compound Icariin has a rejuvenating and up - regulation effect on the nitric oxide signaling meaning it can, with long term use, enhance * your body's natural production of nitric oxide.

Not exact matches

Twenty years ago, they discovered that the gas nitric oxide (NO) is a major player in the complex signaling network that lets our neurons coordinate activity with one another.

In parallel, they also transmit this signal to cells that produce the neurotransmitter nitric oxide to trigger sexual behavior.

The study, which appears online October 29 in the journal Science Signaling, describes a previously uncharacterized interaction between GRK2 and an enzyme called endothelial nitric oxide synthase (eNOS), in which the two enzymes attempt to block one another's activity, with different outcomes on heart function.

The signal from nitric oxide usually overwhelms the signal from 15N15N in mass spectrometers.»

Similarly, the signals trigger an increase in toxic chemicals such as nitric oxide, quinolonic acid, and kynurenic acid, which are bad for the functioning of nerve cells.

Previous work from Snyder's group had shown that the compound CGP3466B prevents the addition of nitric oxide to GAPDH; this turned out to also block GAPDH from interacting with Rheb and continuing the chain reaction's signaling.

Enikolopov says: «If the calcium signal coincides in time with a wave or a puff of nitric oxide — which might be produced even by a neighbouring cell — then this weak calcium signal effectively becomes a strong signal, in terms of its consequences.»

In fact, without nitric oxide, erections would be impossible — the gas acts as a neurotransmitter, carrying the signal for an erection from nerves in the penis to muscles in the same organ.

Dr. Furchgott's identification of nitric oxide as a signalling molecule important in vascular health has revolutionized care for heart, stroke, impotence, and other diseases.

Nitric Oxide Modulates TGF - β — Directive Signals To Suppress Foxp3 + Regulatory T Cell Differentiation and Potentiate Th1 Development.

Arginine stimulates proliferation of ovine trophectoderm cells through MTOR - RPS6K - RPS6 signaling cascade and synthesis of nitric oxide and polyamines.

They have identified two gaseous messenger substances that play an important role in signal transmission in the nerve cells, i.e., nitric oxide and hydrogen sulfide.

Since the recent discovery of tremendous biological effects of nitric oxide, other small gaseous molecules such as carbon monoxide or hydrogen sulfide have emerged to be similarly important in cell signaling, with a great impact on pathophysiology of various diseases.

A transcriptome research of its organs revealed its gene signature is highly evolved and adapted for extreme longevity (slow metabolism, improved insulin gene signaling and glucose homeostasis, thus reduced blood glucose, improved cancer genes, improved endothelial function by eNOS (endothelial Nitric Oxide Synthase) meaning improved vascular coronary blood flow, improved microvasculature arterial and heart endothelium function) but more importantly, to answer your question, some whales display low blood glucose hypoglycemia, this affects the quantity and period of proteins / DNA / cell exposure to glucose glycation, glycosylation and glycoxydation reactions.

Each volunteer's blood was tested for the presence of molecules that signal oxidative stress, others that act as antioxidants, and nitric oxide metabolites.

Studies of satellite cell activation via nitric oxide have opened an exciting area of research on muscle regeneration, growth and the muscle - fiber cytoskeleton that integrates mechanical and biochemical signal transduction with cell and molecular biology of muscle tissue in growth, development, disease, aging and evolution.

Differential Induction of Tobacco MAP Kinases by the Defense Signals Nitric Oxide, Salicylic Acid, Ethylene, and Jasmonic Acid

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

Nitric oxide is a compound that acts as a signaling molecule in the vascular system, dilating blood vessels and increasing nutrient and oxygen delivery to all muscle cells.

Bodybuilding.com says that «When a man becomes sexually stimulated either through physical contact or other sensory stimuli, a signal is sent from the brain to endothelial cells in the penis to release nitric oxide (NO).»

The nitric oxide in turn signals to nearby blood vessels that they need to dilate now in order to deliver more of the oxygen, glucose, glutamate

Another study gave nitrate - rich spinach to healthy participants and measured its effects on their levels of nitric oxide, a signaling molecule normally used in the body to widen the blood vessels.

Dave Asprey: This is fascinating because nitric oxide has been really identified as a signaling molecule in the body that we didn't know that much about even, we'd just five years ago as a major signaler.