Final trial report of sentinel - node biopsy versus
nodal observation in melanoma.
Consequently, until we have better ways of defining those patients who have been cured by SLN biopsy alone (or the long - term results of current prospective trials indicate otherwise),
nodal observation should be chosen by SLN - positive patients only after very careful consideration, and not routinely recommended by surgeons or oncologists as a proven alternative to avoiding CLND.
However, it is clear that nodal basin recurrence can occur years or even decades after initial surgery, [2] so patients who choose
nodal observation are committed to long - term follow - up of uncertain value.
Node - positive patients also had improved 10 - year rates of survival without metastasis and melanoma - free survival compared to those whose nodes were found to be positive on
the nodal observation arm of the study.
Patients who had sentinel node biopsies had significantly greater 10 - year disease - free survival rates than patients who underwent
nodal observation.
Not exact matches
The MSLT - 1 trial demonstrated that patients with a positive SLN undergoing CLND had far better melanoma - specific survival than those patients who manifested
nodal recurrence either on the
observation arm or after a false - negative SLN biopsy (10 - year melanoma - specific survival rates: 62.1 % vs 41.5 % and 34.4 %, respectively).