Sentences with phrase «nomograms in»

New research, published in the Journal of Clinical Pharmacology, explores the accuracy of adult nomograms in children over ten.

Etzioni said the next step is to develop an interface and test the nomogram in a pilot study tentatively planned for later this year.

Not exact matches

While nomograms are common in prostate cancer research, the one developed by the Fred Hutch and UW researchers is the first to determine the likelihood of over-diagnosis on an individual level, said Ruth Etzioni, Ph.D., the paper's senior author.

To develop the nomogram, the researchers created a virtual population model representing U.S. men aged 50 to 84 years from 1975 to 2005 and applied existing data on PSA levels, biopsy practices and cancer diagnosis patterns to learn about cancer progression in patients with and without screening.

«Based on the variability of pharmacokinetic parameters and drug clearance, the two Vancomycin nomograms developed to predict therapeutic Vancomycin concentrations in healthy adults did not accurately estimate dosage regimens in older children regardless of weight or age, and therefore should not be used to aid empiric dosing,» said Dr. Jessica Gillon.

In adults, nomograms are used to calculate the correct dosage of Vancomycin based on a patient's weight and creatinine levels.

However, they state that the nomogram should be validated in an independent sample of patients before it is applied clinically.

«Nomograms offer the ability to personalize survival estimates for patients based upon a host of factors that are clinically relevant when we meet patients,» stated Carole Fakhry, MD, the study's lead author and an associate professor in the Department of Otolaryngology Head and Neck Surgery at John Hopkins University.

Validated nomograms can be advantageous in determining social or biological factors that could be associated with survival.

NRG Oncology's validated nomogram for prediction of survival in oropharyngeal cancer can be found on the NRG Oncology website under the Resources tab.

«These nomograms will help in providing patient - specific estimates of survival that can be used for risk - stratification and discussions of prognosis with patients,» added Dr. Fakhry.

The suggested nomogram dosing regimen was used in 108/178 (60.1 %) of eligible patients during the intervention period.

The 70 patients who were not dosed using the collaborative practice option during the intervention period had a trough distribution similar to historical controls (27.1 % low, 51.4 % in - range, and 21.4 % high; p = 0.02 for proportion of low and in - range groups compared to the collaborative practice nomogram cohort, p = 0.5 for comparison of supratherapeutic groups).

The nomogram also performed well in subsets of patients at the extremes of weight and renal function (Table 3).