Sentences with phrase «non-cd11c expressing cells»

The trimer - expressing cells even died more quickly than cells expressing mutant forms of SOD1 that are found in severe hereditary ALS cases.

Unlike CD8 + DCs that express the cell surface protein CD205, CD8 — DCs, which are positive for the 33D1 antigen, are specialized for presentation on major histocompatibility complex (MHC) class II.

Zhao, Chen and colleagues found that these gastrin - dependent peptide receptor - expressing cells also express a type of serotonin receptor known as the 1A receptor.

Itch responses were blocked by toxin - mediated ablation of Nppb - receptor — expressing cells, but a second neuropeptide, gastrin - releasing peptide, still induced strong responses in the toxin - treated animals.

The findings are consistent with previous studies suggesting that monoclonal antibodies in combination with chemotherapy work better in patients with EGFR expressing cells.»

ALPL - expressing cells were also better at making cartilage or fat.

A machine that detects the fluorescing light then separates out the ALPL - expressing cells.

The researchers found that, in test animals, modification of the blood - forming stem cells resulted in more than two years of stable production of CAR - expressing cells without any adverse effects.

The team went on to show that supplementing heavy stable isotope - labeled forms of these precursors led to incorporation of heavy amino acids into proteins produced in enzyme expressing cells.

T cells are collected from the patient's blood and genetically engineered to express cell - surface proteins called CARs, which recognize specific molecules found on the surface of cancer cells.

In the study, Stephen Maricich and colleagues identified a subpopulation of Atoh1 - expressing cells in hair and whisker follicles within mouse skin that exclusively give rise to Merkel cells during development and adulthood.

These inhibitors effectively targeted and blocked Msi expressing cells, resulting in halted tumor growth in animal models as well as in patient - derived cancer cells, which harbor more complex mutations and are uniformly drug - resistant.

The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.

Deletion of Sox9 prevents skin cancer formation demonstrating the essential role of Sox9 during tumorigenesis and leads to the progressive disappearance of the oncogene expressing cells.

It was even more surprising to observe that in absence of Sox9, pre-cancerous cells disappear over time, suggesting that we can eliminate oncogene expressing cells before cancer formation» comments Jean - Christophe Larsimont, the first author of this study.

«You could imagine developing drugs that protect these telomerase - expressing cells, or ways to use cell therapy approaches to renew livers,» said Artandi.

In lean animals (a and d), F4 / 80 - expressing cells were uniformly small, dispersed, and rarely seen in aggregates.

The fraction of F4 / 80 - expressing cells was greater in moderately obese mice (b and e) and greatest in the severely obese Lepob / ob mice (c and f).

The regression coefficients or slopes that describe the linear relationship between average adipocyte cross-sectional area and percentage of F4 / 80 - expressing cells were comparable across mesenteric, perigonadal, and perirenal depots (Table 1).

We observed similar robust increases of intracellular calcium concentrations in response to KCl and ATP in both GFP - expressing (n = 28) and GFP - nonexpressing cells (n = 12), whereas 5 - HT elicited an increase in intracellular calcium only in GFP - expressing cells (KCl: t (40) = 0.98, p = 0.33; ATP t (38) = 1.04, p = 0.30; 5 - HT: t (38) = 5.24, p < 0.0001 Student's t tests; Fig. 4A, B, F).

The same procedure was used to measure the fraction of CD68 - expressing cells in human tissues.

H, Average responses of 5 - HT3AGFP - expressing cells.

Using an antibody that recognizes the CD68 antigen we performed immunohistochemical analysis on these human samples and calculated the percentage of CD68 expressing cells (Figure 9).

The total number of nuclei and the number of nuclei of F4 / 80 - expressing cells were counted for each field.

G, Average responses of 5 - HT3AGFP - expressing cells to 55 mm KCl, 10 μm ATP and ATP + 1 μm ODS.

The fraction of F4 / 80 - expressing cells for each sample was calculated as the sum of the number of nuclei of F4 / 80 - expressing cells divided by the total number of nuclei in sections of a sample.

We calculated the average adipocyte cross-sectional area and the percentage of F4 / 80 - expressing cells in the perigonadal, perirenal, mesenteric, and subcutaneous inguinal adipose tissue depots from Ay / + female, Lepob / ob female, lean male, and diet - induced obese (DIO) male mice.

In muscle tissue, we observed only rare F4 / 80 - expressing cells between myofibrils.

We showed previously that myostatin circulates in the blood and that systemic effects can be achieved by implanting myostatin - expressing cells into a single site in the lower limb [21]; however, there have been no experiments that have demonstrated conclusively that myostatin normally acts systemically.

In addition, depots from obese animals contained aggregates of F4 / 80 expressing cells (large blue arrows).

«In this case, deletion of OCT4 inhibited the emergence of NANOG - expressing cells, while GATA6 - expressing precursor cells developed normally.»

To ensure that donor and host tissues could be easily distinguished, we generated EFTF - expressing cells from transgenic embryos constitutively expressing a variant of yellow fluorescent protein (Venus YFP)[10].

YFP expressing cells are also observed in the surface ectoderm and left half of the forebrain (G).

We also cultured animals in BrdU and used immunocytochemistry to detect mitotically active cells in mature retinas generated from EFTF - expressing cells.

(B) In contrast, EFTF / YFP - expressing cells generate mosaic retinas with columns of cells spanning the entire retinal width.

SDF - 1 is predominantly overexpressed in skin and kidney, making them the final destinations of CXCR4 - expressing cells.

GCSF and hypoxia inducible factor - 1α (HIF - 1α) have been shown to up - regulate SDF - 1α in the infarcted area in a rabbit ischemia model and promote the migration of CXCR4 expressing cells towards cardiac tissues [47 - 49].

These results suggest that EFTF - expressing cells are multipotent, as they differentiate into the seven retinal cell classes of the mature retina.

These results suggest that EFTF - expressing cells, like bona fide eye field cells, are determined, forming retinal cells and even eye - like structures, when transplanted to another region of the embryo.

Relative mRNA quantification via qPCR revealed that NG2 - positive cells were devoid of Pecam1 expression, but harboured Tek (Tie2) expressing cells (Fig. 4a).

Persomics now provides CRISPR based screening tools for CAS9 expressing cell lines, and we are currently working to extend this.

At 9 - 10 mo of age, such mice were then compared a to age - matched cohorts of untreated BubR1H / H; INK - ATTAC mice, and to BubR1H / H mice lacking the INK - ATTAC system for selective ablation of p16Ink4a - expressing cells.

These models that were chemoresistant were found to have less of those gene expressing cells.

(10) To generate mice in which p16Ink4a - expressing cells could be similarly selectively ablated, van Deursen's team substituted a fragment of the p16Ink4a gene promoter for the Fabp4 promoter, thereby generating BubR1H / H; INK - ATTAC mice.

«That is why detecting early esophageal cancer with fluorescent probes to highly expressed cell surface proteins are necessary.»

In the mammalian cortex, interneurons are a small, extremely diverse group of non-pyramidal GABA - expressing cells, which traditionally have been considered to project locally, hence the term short axon cells.

To impute aging phenotypes directly to p16Ink4a - expressing senescent cells, van Deursen and colleagues with expertise in the aging and senescence of the relevant tissues developed and tested the effects of a pharmacologically - inducible system for the ablation of p16Ink4a - expressing cells.

(6) Following this initial test of abrogating the early, age - related rise in p16Ink4a - expressing cell burden, the investigators probed the effects of leaving BubR1H / H; INK - ATTAC to undergo 5 months of rapid «premature aging» (and thus, to the attendant accumulation of high levels of p16Ink4a - positive cells and onset of «early - aging» phenotypes), and only then inducing ablation of senescent cells with the INK - ATTAC drug - activated system (see Figure 2 (g) below).

Presence of CD8 + T cells in the ectocervical mucosa correlates with genital viral shedding in HIV - infected women despite a low prevalence of HIV RNA - expressing cells in the tissue.

Under normal physiological conditions the number of water molecules entering and exiting an aquaporin - expressing cell is the same, so that the total amount of water in each cell does not change.