Sentences with phrase «non-activated eosinophils»

One of these tools is a type of white blood cell called an eosinophil.

Eosinophils are major immune cells involved in allergic reactions.

The patients also had elevated blood (≥ 300 cells / µl) or sputum (≥ 3 %) eosinophils at screening.

The study found no clear change in blood eosinophils with dupilumab therapy; however, other biomarkers decreased, including fractional exhaled nitric oxide, thymus and activation regulated chemokine, immunoglobulin E and eotaxin - 3, confirming the biologic activity of dupilumab.

Both higher blood eosinophil -LRB-?

The study goal was to determine if these different trajectories were associated with blood concentrations of eosinophils and neutrophils, two types of immune cells that play a role in many respiratory diseases and are routinely measured during medical evaluations.

There were significant interactions between smoking, eosinophil and neutrophil concentrations and FEV1 decline.

Heart tissue from that individual revealed infiltration of white blood cells called eosinophils.

It is not clear, however, how eosinophils produce such an explosive release of mitochondrial DNA.

Researchers looking at the white blood cells called eosinophils found a new weapon in the immune arsenal: toxic webs of DNA flung in less than a second by a kind of cellular catapult.

The toxins that eosinophils secrete can also hurt healthy tissue, so DNA snares may also be doing damage control by corralling the toxins, Simon says.

Some of the IgE - related genes were known to encode proteins produced by eosinophils, a type of white blood cell that promotes inflammation in asthma sufferers» airways.

Therapies that neutralise eosinophils already exist, but they are very expensive and only effective in some asthmatics.

The sputum eosinophil is an inflammation measurement of a white blood cell that increases in asthma and is used to assess the severity of this condition.

The researchers believe these genes may activate the eosinophils, priming them to cause the most damage.

Apart from their call for help to killer cells, eosinophils had another impact on the immediate environment of a tumor.

«There are many studies that link the presence of eosinophils in a tumor with an improved prognosis of the disease.

Carretero and his colleagues therefore investigated whether the outcomes of these immunotherapies might be improved by adding eosinophils.

In subsequent experiments, the investigators showed that eosinophils alone — in the absence of T cells — fail to improve cancer rejection.

Nor was it possible to attract T cells into the tumor when the researchers transplanted non-activated eosinophils, which do not produce attractants, into the mice.

Mice whose eosinophils had been incapacitated using antibodies exhibited poor defense mechanisms against tumors and soon succumbed to the disease.

The researchers want to find out if and how higher levels of eosinophils correlate with better treatment outcomes.

Carretero also showed that the agents released by the eosinophils are, in fact, responsible for attracting the T cells.

While transplantation of T cells alone had only little impact on tumor size in cancerous mice, the researchers achieved substantial regression of the cancer by transplanting both T cells and activated eosinophils.

However, even 120 years after Reinbach's discovery, it still remained elusive whether or not eosinophils actively play a role in fighting the tumor,» says Prof. Günter Hämmerling from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ).

Dr. Weiden said that eosinophil levels are nearly always checked as part of routine blood tests, many patients are unaware of that fact unless they have allergies, which can push levels into an abnormal range.

In «Blood Eosinophils and World Trade Center Exposure Predict Surgery in Chronic Rhinosinusitis: A 13.5 - Year Longitudinal Study,» researchers report on a study of 8,227 firefighters who worked at the WTC site.

«If we treat those with high eosinophil levels differently — earlier, more intensively, or with different medicines — we may be to help them avoid surgery.»

Carretero discovered that eosinophils release special agents that attract the immune system's «professional killers» into cancer tissue.

Because eosinophil levels are nearly always checked as part of routine blood tests researchers were able to look at blood test results from prior to 9/11.

«World Trade Center firefighters needing sinus surgery had more intense, longer exposure to caustic dust and have higher eosinophil levels.»

Researchers also found that those needing sinus surgery had higher levels of eosinophils, white blood cells central to the body's immune response, even before they responded to the disaster.

The fighters at surgical risk in this study had higher - than - average concentrations of eosinophils that would still be considered normal.

Those needing surgery had higher blood concentrations of eosinophils at every point in their lives, including before 9/11.

«This discovery now tells us by using a simple blood or sputum eosinophil count, we can identify which asthma patients can benefit from this new treatment.»

Stone KD, Prussin C and Metcalfe DD: IgE, mast cells, basophils, and eosinophils.

The World Health Organization defines bronchial asthma as a chronic airway inflammation that is caused by various inflammatory cells, including eosinophils (EOS), mast cells and T lymphocytes (1 — 3).

Diverse functions of eosinophils during primary and secondary nematode infections Judy Appleton Cornell University, USA 13th June 201705:00 pm Host: Nicole Affinass, FU Berlin Location: Veterinarium Progressum (VP)-- Oertzenweg 19b, 14163 Berlin

Changing the expression levels of GATA - 1 in monocytes (red) can make them differentiate into eosinophils, erythrocytes, or megakaryocytes.

Oxidant - mediated mitochondrial injury in eosinophil apoptosis: enhancement by glucocorticoids and inhibition by granulocyte - macrophage colony - stimulating factor.

In 1995, a group reported that when GATA - 1 was added to or removed from avian monocyte precursors, it could turn them into erythrocytes, megakaryocytes, and eosinophils (Kulessa et al., 1995).

Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion - competent eosinophil granules in humans.

B. Mean percent eosinophils on histologic evaluation for seven to eight mice in each vaccine dosage group.

B. Mean percent eosinophils were different p <.001.

B. Mean score and standard error of the mean (S.E.) for eosinophils as percent of infiltrating cells for each vaccine dosage group.

The complete blood count panel showed no group changes in percentage of each type for lymphocytes, neutrophils, eosinophils and basophils.

However, eosinophil scores were significantly different between groups (p < 0.001, Anova) with significantly lower scores for nonvaccine groups than for vaccine groups of both mouse strains (p < 0.001 for all comparable group comparisons, Tukey's HSD).

The role of these molecules in driving disease pathology might vary, with described activities of HVEM signaling promoting T cell expansion or survival, analogous to certain activities of OX40 and 4 - 1BB, and other activities of HVEM or LTβR increasing the function of diverse cells such as stromal cells, dendritic cells, macrophages, eosinophils, epithelial cells and keratinocytes.

H&E and immunohistochemical stains for eosinophil major basic protein were performed as described for figure 5.

The CD4 subset is capable of directing B cell responses and humoral immunity, and can modulate the actions of many other cell types including CD8 T cells, dendritic cells, macrophages, eosinophils, and basophils.