Sentences with phrase «non-selectively lead to cell death»

Although they show that dengue can infect neural progenitor cells like Zika can, dengue infection does not stunt the cells» growth or lead to cell death.

A malfunction of fatty acid regulation can, however, lead to cell death and — depending on the type of cell — trigger diseases such as diabetes.»

Cultures representing two other hereditary liver diseases, alpha 1 — antitrypsin deficiency (a protein - folding disorder that leads to cell death and liver failure) and glycogen storage disease, type 1a (in which a liver enzyme deficiency impairs the body's glucose metabolism), also displayed disorder - specific abnormalities.

Brain injuries, whether caused by trauma or neurodegeneration, lead to cell death accompanied by considerable functional impairment.

These proteasomes usually rapidly stop functioning, leading to the accumulation of damaged proteins that further impair cell function, contributing to the vicious cycle that leads to cell death.

Even a change in temperature of + / - 5 ° C subjects the cell to a heat shock or cold shock, which can lead to cell death after a few hours.

These defects, in turn, affect the cell's ability to generate energy and can potentially lead to cell death and are associated with aging and various neurological diseases.

Meanwhile, other groups developed new ways of killing bacteria with vancomycin: One alteration found a novel way to halt cell wall construction, whereas another caused the outer wall membrane to leak, leading to cell death.

The pathological hallmark of this disease is the accumulation of alpha - synuclein, which in turn leads to cell death and consequently to problems in neurotransmission.

«If you have an immature lung that is genetically predisposed to getting BPD, then it's getting hit with supplemental oxygen, this sets off inflammation and leads to cell death.

Telomeres gradually break down and shrink as cells age, eventually leading to cell death which is a normal part of human growth and aging.

The inhibition of Rac1 also led to cell death in mouse lungs cultured in the lab.

Also, research in other animal models, such as rodents, has shown anesthesia exposure early in life can lead to cell death in the brain and cognitive impairments.

The faulty gene leads to cell death in neurons in the brain resulting in gradual physical, mental and emotional changes, and ultimately death.

Sinclair says he's not sure exactly how SIRT3 and SIRT4 beef up the mitochondria's energy output, but that events leading to cell death are at the very least delayed when there are vast quantities of the enzymes.

Vacuolating cytotoxin A (VacA) was previously the only main H. pylori factor known to act on mitochondria, causing cellular membrane and organelle dysfunction and leading to cell death.

Animal studies have shown that lengthy or multiple experiences with anesthesia can lead to cell death and problems with the formation of connections among brain cells.

Such undesired protein waste can be toxic for cells and may even lead to cell death.

SiRNA is a segment of RNA that when delivered into a cell interferes with expression of a specific mutated gene, leading to cell death.

The Zika virus is known to negatively impact the growth of fetal brains and a group of researchers publishing in the journal Cell Stem Cell have investigated the effect of Zika on the adult brain reporting that infection can lead to cell death and reduced proliferation.

Chromosomal instability (CIN) often results in aneuploidy, which compromises cell fitness and leads to cell death.

The greater presence of yellow in C, a couple days after transplantation, displays the activation of an enzyme that leads to cell death.

Both excessive acidity and alkalinity can affect your bodily functions and lead to cell death.

In the long term, this damages the neurons, eventually leading to cell death.

Sugar depletes the body of critical electrolytes, antioxidants, and minerals, which leads to cell death, muscle spasms, insulin resistance, and other health defects.

Basically the cells are under so much stress that there main protective shield (GSH) gets worn down and oxidative stress damages the mitochondria and the DNA leading to cell death.

Basically inorganic arsenic in the body can lead to cell death.

Unable to flush out calcium, the cell may become overstimulated, damaging the cells and even leading to cell death (apoptosis).

The guinea pig muscles were damaged by lipid peroxidation leading to cell death.

Oxygen free radicals are toxic for cells, since they cause damage to cell membranes surrounding living cells as well as their nucleus and other inner organelles, eventually leading to cell death.

The disruption of the cell's normal pathway usually leads to cell death.

Not exact matches

As irresponsible as that was — leading to the death of a covert asset who had infiltrated a dangerous terror cell — it taught Failing POTUS one thing: he has the authority to declassify anything any time.

In wet AMD, fluid leakage damages the RPE, leading to the death of light - sensitive cells and loss of vision.

The results could provide insights into the Zika virus» recent emergence as a global health emergency, and also point to inhibitors of the protein p53 as potential leads for drugs that could protect brain cells from cell death.

When this level was high enough, stress signals can lead to DNA damage and then trigger a form of cell death called parthanatos.

«Imagine if we could create circuits that detect defects in cancer cells and then turn on pathways that lead to the death of those cells,» he says.

There is also some evidence that repeated bouts of intense exercise on consecutive days can lead to white blood cell death or dysfunction.

The disease is caused by a genetic mutation that leads to abnormal clumps of protein in the brain, eventually resulting in the atrophy and death of nerve cells.

If another molecule, for example an antibody, touches this switch, a lethal mechanism is triggered that can lead to very fast cell death.

Roughly 2 % of people over age 35 have chronic glaucoma, in which fluid builds up inside the eyeball, leading to increased pressure and eventual death of cells in the optic nerve.

Now, two new studies have added another disease: multiple sclerosis (MS), an autoimmune disorder that strips away nerve cells» protective covers, leading to muscle weakness, blindness, and even death.

In patients with ALL, this leads to a sharp fall in serum levels of asparagine, hindering protein synthesis in malignant cells and inducing apoptosis, or programmed cell death.»

The new chimera interferes with HER2 and HER3 signaling and ultimately leads to cancer cell death, as shown in the group's recent publication in Molecular Therapy: Nucleic Acids.

«After circulatory arrest, spreading depolarization marks the loss of stored electrochemical energy in brain cells and the onset of toxic processes that eventually lead to death.

Telomeres shorten every time a cell divides, and ultimately the loss of telomeres leads to cellular senescence, where cells cease to divide, and eventually, cell death.

These proteins are thought to be a hallmark of Alzheimer's disease, and their formation may trigger other changes that lead to the death of brain cells.

«Shutting off vital tumour growth processes can lead to the death of human brain tumour - initiating cells.

Still, by identifying the human hairless gene as an important master switch in regulating cell death in a hair follicle — a discovery that could lead to gene therapies for unwanted hair growth — Christiano emerged as a new star in the field, and a glamorous one.

The researchers from UC Berkeley, UC San Francisco Benioff Children's Hospital Oakland Research Institute (CHORI) and the University of Utah School of Medicine hope to re-infuse patients with the edited stem cells and alleviate symptoms of the disease, which primarily afflicts those of African descent and leads to anemia, painful blood blockages and early death.

Then, in the presence of TB drugs, that increased respiration will lead to rapid death of the cells.