Sentences with phrase «non-viral vector systems»

Since the discovery of the genetic basis for cystic fibrosis in 1989, scientists have developed a variety of viral and non-viral vector systems for delivering a corrected CFTR gene back into lung cells.

Not exact matches

In January 2008, he started his own group in ISCR and succeeded in making a non-viral single vector reprogramming system, which has been applied to both mouse and human cells using the piggyBac transposon in collaboration with Prof. Andras Nagy in Toronto (Kaji, et al., Nature, 2009, Woltjen, et al., Nature, 2009).

Viral vectors have the main adverse effect of inducing neutralizing antibodies, while several non-viral vectors present toxic effects (e.g. respiratory system).14, 15 In an effort to deliver efficiently the necessary drug concentration to the tumor site and prevent systemic adverse effects, the concept of administering local treatment for lung cancer has been explored.