It suggests that all of
those noncoding genetic associations are not random, but indicative of the intricate regulatory genetic networks underlying complex human traits.
One way to control expression, he explains, is through microRNA, small pieces of
noncoding genetic material that control whether a gene's protein is generated from the DNA blueprints inside cell nuclei.
Not exact matches
Many are probably simply the consequence of 6 million years of
genetic drift, with little effect on body or behavior, whereas other small changes — perhaps in regulatory,
noncoding sequences — may have dramatic consequences.
At first, Sprecher suspected that either they had performed the
genetic analysis incorrectly or the missing mutation was hiding in a
noncoding or «junk» region of the genome.
They extracted and amplified DNA from these samples, concentrating on microsatellites, repetitive
noncoding DNA sections that rapidly accumulate
genetic changes.
J H S Tong and colleagues report a study that brings into sharp focus the likely relevance of
noncoding variants for the
genetic risk associated with Attention deficit hyperactivity disorder (ADHD).
These robust regulators of
genetic programs comprise a novel class of small,
noncoding RNAs that regulate gene expression by repressing protein translation.
Undoubtedly a significant proportion of important
genetic variants lie in
noncoding regions, where they exert a regulatory effect.
As our understanding of the
noncoding portion of the genome improves, it will become even more apparent that whole - genome sequencing (and not exome sequencing) will be required to characterize the full extent of phenotypically - relevant
genetic variation in humans.
Messenger RNAs (mRNAs) that code for proteins and
noncoding RNAs are key components in the transmission of
genetic information in all life forms - from viruses to complex mammalian organisms.