Sentences with phrase «noncoding micrornas»

S. L. Page and Morris Goodman, «Catarrhine phylogeny: Noncoding DNA evidence for a diphyletic origin of the mangabeys and for a human - chimpanzee clade,» Molecular Phylogenetics and Evolution 18 (1): 14 - 25 (January 2001).

We learned about the noncoding region of the gene, the gene responsible for lactose intolerance, and finished Lesson Four.

The Dengue virus contains discretely folded RNA structures that confer the ability to resist a powerful host cell enzyme and produce a disease - inducing noncoding RNA.

My lab investigates what these noncoding RNAs (ncRNAs) do within and outside of cells, where regulators of their expression are located in the genome, and how perturbations of ncRNAs and their regulators contribute to disease.

342/12: 15 LARVA: An integrative framework for Large - scale Analysis of Recurrent Variants in noncoding Annotations.

Throughout the 2000s, Wistar scientists made seminal discoveries in the field of epigenetics and RNA transcription, contributing new knowledge on the role of histone modifications in gene regulation and DNA repair and how different RNA species, including microRNAs (miRNA) and long noncoding RNAs (lncRNA), are generated and how they regulate gene transcription.

With the sequencing and annotation of genomes and transcriptomes of several eukaryotes, the importance of noncoding RNA (ncRNA)- RNA molecules that are not translated to protein products - has become more evident.

CSHL scientists test an antisense method of targeting long noncoding RNAs overexpressed in breast cancers...

Benchmarking tools for the alignment of functional noncoding DNA.

Whitehead Institute researchers report that 10 long noncoding RNAs (lncRNAs) play a vital role in the regulation of white fat cells.

A team of scientists from Whitehead Institute and other institutions has shown for the first time how two long intergenic noncoding RNAs (ncRNAs) in brewer's yeast (Saccharomyces cerevisiae) contribute to a location - dependent switch for the yeast FLO11 gene to toggle between active and inactive states.

These miRKO models provide a tool for understanding how noncoding RNAs contribute to the specification of cell fate and function, and how deregulation of these RNAs may contribute to human disease.

PANCR, the PITX2 adjacent noncoding RNA, is expressed in human left atria and regulates PITX2c expression.

Using genome - scale RNA interference (RNAi) screening and other high - throughput methodologies to uncover the functions of noncoding RNAs in the mammalian system, the McManus Lab has generated and characterized many small (micro) RNA conditional knockout mice.

Almost all of the noncoding RNAs (ncRNAs) known are shared between the two species.

The Noncoding RNA project was developed by the Michael McManus Lab in collaboration with colleagues at UCSF and the Gladstone Institute.

Benchmarking tools for the alignment of functional noncoding DNA D.A. Pollard, C.M. Bergman, J. Stoye, S.E. Celniker, and M.B. Eisen BMC Bioinformatics (2004) 5:6 Correction Download entire paper in pdf format Download correction in pdf format

Genome editing technology enables precise modification of individual protein coding genes, as well as noncoding regulatory sequences, enabling the elucidation of functional effects in human disease relevant cellular systems.

Mosher and colleagues observed low level transcription of tissue specific genes as well as LINE elements and other noncoding regions of the genome, indicative of a high level of transcription throughout the ES genome [22].

Messenger RNAs (mRNAs) that code for proteins and noncoding RNAs are key components in the transmission of genetic information in all life forms - from viruses to complex mammalian organisms.

For example, some forms of noncoding RNA (meaning it's not involved in translation to proteins) have epigenetic activity.

In it, the authors review bioinformatics approaches for evaluating single - base substitutions in both coding and noncoding regions, with an emphasis on large cancer resequencing efforts including the Tumor Sequencing Project, the Cancer Genome Atlas (TCGA), and the AML1 cancer genome.

As a result, reference gene collections remain incomplete - many gene models are fragmentary, and thousands more remain uncataloged, particularly for long noncoding RNAs (lncRNAs).

Filed Under: Cancer Genomics, Uncategorized Tagged With: cancer, DNA, genetics, genome, genomics, noncoding, research, selection, sequencing, snps, splicing, TCGA

Noncoding transcripts originating upstream of the immunoglobulin constant region (I transcripts) are required to direct activation - induced deaminase to initiate class switching in B cells.

RNA - seq analysis detected aberrant splicing in DONSON due to one of these noncoding variants, showing a causative role for DONSON disruption in MMS.

Jennifer Stauffer: Assessing the Function of Highly Conserved Noncoding Elements in Drosophila melanogaster via Captured Segment Exchange

Huang Y - F, Gulko B, Siepel A. Fast, scalable prediction of deleterious noncoding variants from functional and population genomic data.

The authors also leveraged our current knowledge of gene - phenotype relationships, and the comprehensive nature of WGS data, to identify three pathogenic noncoding variants.

The HGP and subsequent research efforts have changed the consensus view of genes and noncoding DNA, casting them as part of an increasingly complex image of genes, DNA and other components of the genome.

It suggests that all of those noncoding genetic associations are not random, but indicative of the intricate regulatory genetic networks underlying complex human traits.

Integrating this new information into computational models, my colleagues and I predicted that about 5 percent of HARs function as noncoding RNAs, while most are enhancers that control gene expression during embryonic development.9

The researchers zeroed in on a single - nucleotide polymorphism (SNP) that appeared to be the causal mutation, typically consisting of an adenine nucleotide but appearing as a guanine nucleotide in roughly a third of the population, located in a region of noncoding DNA that falls within the PHACTR1 gene.

Many, if not most of the genomic loci associated with human traits lie in noncoding regions.

Ironically, another reason people like exome sequencing is because of the limited scope: it essentially doesn't interrogate the regions (noncoding) and variant types (SVs) that are more difficult to interpret.

According to datasets generated by projects like ENCODE and FANTOM5, noncoding regions also exhibit an astonishing amount of biochemical activity suggestive of diverse functions.

It's a complicated picture, to be sure, but it suggests some specific areas in which noncoding variants are exerting a cis - regulatory effect on the LPA gene.

In addition, the majority of HARs are noncoding — they do not appear to encode for specific genes.

Sessions will cover recent findings in RNA polymerase II regulation, including the contributions of noncoding RNAs, chromatin structure and post-translational modifications, and other factors that regulate gene expression.

As our understanding of the noncoding portion of the genome improves, it will become even more apparent that whole - genome sequencing (and not exome sequencing) will be required to characterize the full extent of phenotypically - relevant genetic variation in humans.

We know, of course, that noncoding portions of the human genome contain functional elements contributing to phenotypic variation.

These included tier 1 (coding), tier 2 (conserved / regulatory), and tier 3 (unique noncoding) variants.

Rather than modify protein structure and function, these noncoding variants frequently impact regulatory elements and thereby alter the quantitative and spatiotemporal regulation of gene expression.

Eukaryotic cells produce diverse types of protein - coding and noncoding RNAs, some of which have a direct role in the regulation of gene expression.

It is as if Saccharomyces cerevisiae has found the philosopher's stone but instead of changing lead to gold, it turns noncoding DNA into a gene that codes for a partially structured protein.

Here at La Jolla Institute, I am excited to continue utilizing noncoding RNAs as a tool for better understanding other aspects of T cell biology.

In particular, our research focuses on developmental origins of health and disease with an emphasis on environmental exposures and epigenetic mechanisms (DNA methylation and noncoding RNA).

Undoubtedly a significant proportion of important genetic variants lie in noncoding regions, where they exert a regulatory effect.

The session will cover current understanding of how cells regulate and monitor the production and turnover of coding and noncoding RNAs.

These robust regulators of genetic programs comprise a novel class of small, noncoding RNAs that regulate gene expression by repressing protein translation.