Sentences with phrase «noncoding regions of»

Mosher and colleagues observed low level transcription of tissue specific genes as well as LINE elements and other noncoding regions of the genome, indicative of a high level of transcription throughout the ES genome [22].

Using a specific work flow, they assessed both the coding and noncoding regions of the human genome, including the evaluation of highly polymorphic SNPs, structural and copy number variations, as well as 69 control genomes sequenced by the same procedures.

They also uncovered five CNVs linked to autism that land in noncoding regions of the genome.

Most of the mutations identified in the new work land in genes, but some affect noncoding regions of the genome.

«We used 377 markers that are generally located in noncoding regions of the genome, ones that are likely to be neutral, where there is no natural selection involved,» says Rosenberg.

The conclusion is that many of these noncoding regions of DNA should be more broadly categorized as «appendage enhancers» rather than «limb enhancers,» and snakes may have retained these noncoding DNA elements due to their role in phallus development.

The research team is turning their attention to the noncoding region of the mammalian genome.

We learned about the noncoding region of the gene, the gene responsible for lactose intolerance, and finished Lesson Four.

Not exact matches

Peixoto finds the paternal bias surprising as well, although she already suspected that the inherited component of autism would be more apparent in noncoding regions.

Assessing the influence of individual DNA base changes is particularly difficult in noncoding regions, so they instead identified bigger alterations, so - called structural variants, in which large sequences of DNA are inverted, duplicated, or deleted.

Once dismissed as «junk DNA,» researchers have found that some of these so - called noncoding regions are shared among mammals, suggesting they play an important function.

«People used to call the noncoding regions junk DNA, but I see it as a jungle that has not been explored,» said Christopher Gregg, Ph.D., assistant professor in Neurobiology and Anatomy at U of U Health.

Characterization of the noncoding regulatory landscape within human - specific duplicated regions.

«We are exploring the noncoding regions to try to discover new parts of the genome that might control different diseases.»

Like many genes, Dscam consists of protein - coding regions called exons interspersed with noncoding regions.

At first, Sprecher suspected that either they had performed the genetic analysis incorrectly or the missing mutation was hiding in a noncoding or «junk» region of the genome.

One of the noncoding de novo mutations was 254 kilobases downstream of FGFR2, in a noncoding region that looks (according to chromatin marks) like a neural crest enhancer.

It should be noted, however, that the typing method used here is based on the analysis of a noncoding spacer region within the rRNA gene cluster of B. burgdorferi [16, 19, 28, 35].

Undoubtedly a significant proportion of important genetic variants lie in noncoding regions, where they exert a regulatory effect.

According to datasets generated by projects like ENCODE and FANTOM5, noncoding regions also exhibit an astonishing amount of biochemical activity suggestive of diverse functions.

Ironically, another reason people like exome sequencing is because of the limited scope: it essentially doesn't interrogate the regions (noncoding) and variant types (SVs) that are more difficult to interpret.

Many, if not most of the genomic loci associated with human traits lie in noncoding regions.

The researchers zeroed in on a single - nucleotide polymorphism (SNP) that appeared to be the causal mutation, typically consisting of an adenine nucleotide but appearing as a guanine nucleotide in roughly a third of the population, located in a region of noncoding DNA that falls within the PHACTR1 gene.

Noncoding transcripts originating upstream of the immunoglobulin constant region (I transcripts) are required to direct activation - induced deaminase to initiate class switching in B cells.