Mutations in two
nonessential genes specifically block the phagocytosis of cells programmed to die during development.
In their current work, Venter, along with project leader Clyde Hutchison at JCVI, set out to determine the minimal set of genes needed for life by stripping
nonessential genes from Syn 1.0.
Not exact matches
All this enabled them to systematically whittle away
genes that either had
nonessential functions or duplicated the function of another
gene.
Using global transposon mutagenesis, we isolated and characterized
gene disruption mutants for 100 different
nonessential protein - coding
genes.
Such
genes are known as
nonessential.
One of those
genes might appear
nonessential on its own — like a jet engine that could be shut down without causing the plane to crash — but if its buddy was also taken away, the cell would die.
In doing so, they found that many
genes thought to be
nonessential to life were actually one - half of
gene pairs with the same function.
The dystrophin
gene is very large (79 exons), but much of the sequence appears to be
nonessential.