Systemic delivery of TNF - related apoptosis - inducing ligand (TRAIL) elevates levels of tissue inhibitor of metalloproteinase - 1 (TIMP - 1) and prevents type 1 diabetes in
nonobese diabetic mice.
Not exact matches
One of the most popular models is the immunodeficient
nonobese diabetic severe combined immunodeficiency (NOD scid) gamma (NSG) transgenic
mouse line, which can be endowed with a humanized immune system using CD34 + hematopoietic stem cells.
To further validate our result in clinical samples, we obtained primary tumor from patients with advanced breast cancer and the tissue was passaged once in
nonobese diabetic / severe combined immunodeficient
mouse without in vitro culture.
Because PD - L1 / programmed cell death (PD - 1) deficiency accelerates development of diabetes in
mouse models, Nasr et al. hypothesized that a defect in the PD - L1 / PD - 1 pathway may underpin the hyperglycemia observed in the
nonobese diabetic (NOD)
mouse model.
The
nonobese diabetic (NOD)
mouse is a common model used for studying treatments for diabetes.
Genes affecting autoimmune type 1 diabetes susceptibility in the
nonobese diabetic (NOD)
mouse (Idd loci) have been mapped using a congenic strain breeding strategy.