Sentences with phrase «nonobese diabetic mouse»
Systemic delivery of TNF - related apoptosis - inducing ligand (TRAIL) elevates levels of tissue inhibitor of metalloproteinase - 1 (TIMP - 1) and prevents type 1 diabetes in nonobese diabetic mice.
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One of the most popular models is the immunodeficient nonobese diabetic severe combined immunodeficiency (NOD scid) gamma (NSG) transgenic mouse line, which can be endowed with a humanized immune system using CD34 + hematopoietic stem cells.
To further validate our result in clinical samples, we obtained primary tumor from patients with advanced breast cancer and the tissue was passaged once in nonobese diabetic / severe combined immunodeficient mouse without in vitro culture.
Because PD - L1 / programmed cell death (PD - 1) deficiency accelerates development of diabetes in mouse models, Nasr et al. hypothesized that a defect in the PD - L1 / PD - 1 pathway may underpin the hyperglycemia observed in the nonobese diabetic (NOD) mouse model.
The nonobese diabetic (NOD) mouse is a common model used for studying treatments for diabetes.
Genes affecting autoimmune type 1 diabetes susceptibility in the nonobese diabetic (NOD) mouse (Idd loci) have been mapped using a congenic strain breeding strategy.