Sentences with phrase «nonsynonymous site»
They investigated the unfolded nonsynonymous site frequency spectra using 13 different selection models, including some complex two - parameter and three - parameter models.
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Within this interval, only three homozygous SNPs resulted in nonsynonymous, start, or stop codon gain or loss, or intron splice site gain or loss.
By sequencing the exomes of multiple individuals, isolating what we'd call «tier 1» variants — Nonsynonymous, nonsense, splice site, or frameshift - indel — and then removing all known common variants from public databases, Dr. Shendure and colleagues can reduce 20,000 gene candidates down to a handful.
Second, we investigated rates of evolution in a deeper phylogenetic scale by comparing divergence at nonsynonymous and synonymous sites (dN / dS) between rabbits and mice.
To evaluate the patterns of selective pressures acting on mainland and island fox mitogenomes, we estimated the proportion of nonsynonymous (dN) and synonymous variable (dS) sites throughout all of the protein - coding genes (Table 2).