However, an excess of approximately 40
nonsynonymous substitutions compared with that expected by chance (P = 0.07) suggests that some nonsynonymous mutations have been selected and are contributing to oncogenesis.
They reveal 341 fixed
substitutions (35
nonsynonymous, 173 synonymous, and 133 noncoding) between the 2014 EBOV and all previously published EBOV sequences, with an additional 55 single - nucleotide polymorphisms (SNPs; 15
nonsynonymous, 25 synonymous, and 15 noncoding), fixed within individual patients, within the West African outbreak.