Clough, R.W., Peterson, B.R., Steenbergen, J.L., Jobe, P.C, Eells, J.B., Browning, R.A., Mishra, P.K. (1997) Neurite extension of developing
noradrenergic neurons is impaired in genetically epilepsy - prone rats (GEPR - 3s): an in vitro study on the locus coeruleus.
Title: Genetic Predictors of Response to Serotonergic and
Noradrenergic Antidepressants in Major Depressive Disorder: A Genome - Wide Analysis of Individual - Level Data and Meta - Analysis Author: K. E. Tansey et al..
They also show altered
noradrenergic transmission in the hippocampus and cerebral cortex and degeneration of basal forebrain cholinergic neurons by 6 months of age.
Adolescent development influences functional responsiveness
of noradrenergic projections to the hypothalamus in male rats
Intranasal NPY also modulated the response of the
brain noradrenergic system to the traumatic stress of SPS.
Moreover, some neuroblastoma cells exhibit plasticity and are able to shift between the NCC - like and
noradrenergic identities.
It is connected to cognitive areas such as the cortex and the hippocampus, but also to distinct areas in the brainstem like the locus coeruleus, which is the
main noradrenergic nucleus in the brain and regulates stress and panic responses.
Distinct transcription factor networks predicate different tumor identities, corresponding to
sympathetic noradrenergic or mesenchymal / neural - crest cell like identities.
Some also act
on noradrenergic and dopaminergic receptors (alongside hormones) to produce satiety (4)
Clomipramine hydrochloride reduces the clinical signs of separation anxiety by affecting serotonergic and
noradrenergic neuronal transmission in the central nervous system.
Modeling a Negative Response Bias in the Human Amygdala
by Noradrenergic - Glucocorticoid Interactions
Supporting this proposition is much evidence that strength of emotional memories is moderated by glucocorticoid and
noradrenergic activation at the time of consolidation [5, 6].
Further support comes from literature on intrusive emotional memories, which occur involuntarily and are typically vivid and distressing [7], and that are also associated with elevated levels of both glucocorticoid and
noradrenergic response [8].
Numerous studies have previously found that memory consolidation can be impaired by pharmacological means to interrupt the glucocorticoid -
noradrenergic surge that underpins memory consolidation [29].
Title: Genetic predictors of response to serotonergic and
noradrenergic antidepressants in major depressive disorder: a genome - wide analysis of individual - level data and a meta - analysis Author: K. E. Tansey et al..
Molecular genetic findings support the thesis that dopaminergic, serotonergic, and
noradrenergic neurotransmission pathways account for the etiology of this complex disease.
«Other people have found that
noradrenergic neurons, which are active when you are running, shut down when eating or grooming.
Dan suspects that these GABAergic neurons in the medulla have the opposite effect of stress neurons, such as
the noradrenergic neurons in the pons, another ancient part of the brain.
So it seems like when you are relaxed and enjoying yourself,
the noradrenergic neurons switch off and these GABAergic neurons in the medulla turn on,» she said.