Sentences with phrase «normal bone marrow cells»

Normal bone marrow cells, however, are spared, which may explain why bean extracts kill off colon cancer cells, but seem to leave normal colon cells alone.

To confirm the finding, normal bone marrow cells were exposed to either IMGN632 or X-ADC for 72 hours at a concentration highly active against AML cells (100 pM), and the degree of caspase 3 activation, a marker of apoptosis, in different cell populations was assessed by flow cytometry (supplemental Figure 4).

Importantly, IMGN632 was effective at concentrations well below those that affected normal bone marrow cells, suggesting the potential for efficacy in AML patients with reduced likelihood of myelosuppressive side effects and favorable safety profile.

Myelosuppression is a well - established side effect of current AML therapies, with prolonged events leading to an increased risk of infections and death.44 Consequently, therapies that preferentially kill leukemic cells over normal bone marrow cells are urgently required, and the overexpression of CD123 on AML leukemic stem cells and blasts compared with normal hematopoietic cells contributes to its attractiveness as a therapeutic target in this disease.6, 45 However, severe myelosuppression and myeloablation have emerged for some investigational CD123 - targeted treatment modalities.

Patients were considered free of MRD if less than one cancer cell could be detected in 1,000 normal bone marrow cells.

Not exact matches

Multiple myeloma causes tumors to grow in the bone marrow, preventing the production of normal blood cells.

In humans, a comparison of bone marrow from 14 normal bone marrow donors, 35 multiple myeloma patients and 11 patients with a noncancerous condition called monoclonal gammopathy of undetermined significance (MGUS) showed that Runx2 levels were significantly higher in the multiple myeloma cells.

In DBA, a mutation prevents a patient's bone marrow from producing normal quantities of red blood cells, resulting in severe, sometimes life - threatening anemia.

Subsequent transplant of millions of human T - ALL cells into normal mice that were then treated with an anti-CXCR4 drug induced remission within two weeks, with diseased spleen and bone marrow tissue nearly returning to normal.

Then they would transfuse donor bone marrow rich in the highly prized stem cells that are capable of generating new, normal blood.

Everybody has suPAR, which is produced by bone marrow cells, in their blood, with normal levels around 2400 picogram per milliliter (pg / ml).

Bone marrow from the p16 - deficient mice made 3 times as many blood - forming stem cells as bone marrow from the normal mice Bone marrow from the p16 - deficient mice made 3 times as many blood - forming stem cells as bone marrow from the normal mice bone marrow from the normal mice did.

«Chemotherapy is applied in one cycle then stopped to allow your bone marrow and normal stem cells to recover from the damage, and then another cycle starts again,» he said.

For every 100 DNA fragments, only one may come from the tumor, and the rest may come from normal cells, mainly bone marrow cells,» said Dr. Razavi.

People in an acute stage of the disease often develop severe anemia, because the leukemia cells, which live almost ten times as long as their normal counterparts, replace healthy cells in the bone marrow.

They multiply quickly and interfere with the bone marrow's ability to make normal blood cells, leading to life - threatening infections and bleeding.

Researchers at the Whitehead Institute in Cambridge, Massachusetts, US, have now found that adult stem cells in bone marrow gradually lose their ability to regenerate without their normal complement of membrane - bound prions.

To devise a potential new therapy, the investigators engineered a population of bone marrow derived mesenchymal stem cells loaded with oncolytic herpes simplex virus (oHSV), which specifically kills dividing cancer cells while sparing normal cells.

When blasted with 10 Gy of irradiation — enough to wipe out all blood stem cells in the bone marrow of normal mice — mutant mice that were unable to fully activate p53 experienced only a modest blood count drop.

(5 - azacytidine, Vidaza) A demethylating agent, this medicine interacts with DNA to restore normal growth of blood cells in the bone marrow.

(Dacogen) A demethylating agent, this drug interacts with DNA to restore normal growth of blood cells in the bone marrow.

In a third of MDS cases, over time, very immature bone marrow cells called blasts may increase in number and fill the bone marrow, displacing the normal red and white blood cells and platelets that are produced there.

CFU - GM assays using bone marrow derived cells yield very few colonies in repsonse to interleukin 3, but normal colony growth occurs in response to GM - CSF

She will study how normal, healthy bone marrow stem cells find a niche and how niche environment regulates stem cell functions such as self - renewal and differentiation.

Her goal is to define the molecular architecture and functional significance of a niche, determine how tumor growth impacts the niche, learn how benign and malignant cells compete within a niche, and use this knowledge to design precisely targeted anti-cancer treatments that spare normal bone marrow and improve the efficacy of stem cell - based therapies.

Stem Cells Make Bone Marrow Cancer Resistant to Treatment Scientists at the Johns Hopkins Kimmel Cancer Center provided evidence that cancer stem cells for multiple myeloma share many properties with normal stem cells and have multiple ways of resisting chemotherapy and other treatmCells Make Bone Marrow Cancer Resistant to Treatment Scientists at the Johns Hopkins Kimmel Cancer Center provided evidence that cancer stem cells for multiple myeloma share many properties with normal stem cells and have multiple ways of resisting chemotherapy and other treatmcells for multiple myeloma share many properties with normal stem cells and have multiple ways of resisting chemotherapy and other treatmcells and have multiple ways of resisting chemotherapy and other treatments.

In her project, Sipkins will investigate molecular characteristics of tissue microenvironments, or «niches,» within the bone marrow and how normal, healthy hematopoietic stem cells, which give rise to the many kinds of blood cells, compete with malignant cells to occupy these coveted niches.

If successful, the bone marrow will then produce all new blood cells, including normal hemoglobin.

the removal and evaluation of bone marrow cells to determine if the cells are normal, if cancer has spread to the bone marrow or if there is a problem with blood cell production.

The signs that we see in dogs are usually related to decreased numbers of normal cells (such as red blood cells which carry oxygen, white blood cells that fight infection and platelets that help with clotting) which are made in the bone marrow.

Unfortunately, normal healthy cells can also be damaged or destroyed by the radiation, particularly actively dividing cells like those of the intestinal lining, bone marrow and immune system.

This means that abnormal blood cells can be produced or that production of normal cells can be halted due to an action of chloramphenicol on patient bone marrow.

Immunoglobulin levels can also remain above normal in all forms of autoimmune disease (ref + see ANA) and when tumors have developed in certain bone marrow cells.