Moreover, when analyzed with gene expression patterns
of normal brain cells, the four GBM subtypes associate with different cell lineages.
DIPGs are known as one of the most challenging tumors to treat because cancer cells are intimately intermingled
with normal brain cells in a part of the brain that can not be surgically resected.
TGen researchers have linked TROY to the cellular mechanisms that enable glioblastomas to
invade normal brain cells, and resist anti-cancer drugs.
For example, the drug might kill cancer cells, but also accidentally
block normal brain cells from signaling other cells.
The researchers found much higher levels of heparanase in childhood brain tumours than in the normal brain, and furthermore, a molecule that can block this enzyme induces cell death in medulloblastoma cells in culture,
while normal brain cells were not affected.
• Optimise omega 3s: Low levels of omega - 3 fatty acids are involved in
normal brain cell function, insulin control and inflammation.
Their study, reported in the journal PLoS Computational Biology, suggests that breast feeding not only taps
the normal brain cells involved in secreting oxytocin.
In the years since Shatz's discovery of MHCI in
normal brain cells, other scientists have been studying the action of immune molecules in the brain, as well.
They noticed that before the development of
a normal brain the cells lining the neural tube, a structure that eventually becomes the brain and spinal cord, have extreme differences in ionic charge within and outside the membrane that houses the cells.
Because tumor cells in the brain frequently divide,
normal brain cells would remain unaffected by the electric fields, the team reports online this week in the Proceedings of the National Academy of Sciences.