Sentences with phrase «normal breast cancer»

In this most recent study, the researchers analyzed the various mechanical changes to breast cancer cells in which myoferlin levels were dramatically reduced compared to normal breast cancer cells.

In addition to using normal breast cancer cells in the experiments, the team also used cancer cells that had been genetically engineered to lack either GSTO1 or RYR1.

Not exact matches

Many women find their own breast cancers, but it is something they notice as part of their normal activities, not during a breast self - exam.

However, the rats are protected from breast cancer long after hormone levels return to normal.

And because mouse embryo cells with inactivated copies of BRCA2 are more sensitive to ionizing radiation than normal cells are, «it's a reasonable extrapolation» that breast cancers with mutated copies of the gene may be especially good candidates for radiation therapy.

If a breast cancer line had silently contaminated Klonisch's cell culture early on, it would have been subject to the usual technique for immortalizing a normal cell (which involves applying enzymes, antibiotics and antibiotic - resistant genes).

Being obese or having a higher body mass index (BMI) while carrying a BRCA (BReast CAncer gene) mutation is positively linked with higher levels of damage to the DNA in normal breast gland cells, new research sugBReast CAncer gene) mutation is positively linked with higher levels of damage to the DNA in normal breast gland cells, new research sugbreast gland cells, new research suggests.

Plakoglobin is a component of two important structures involved in cell - to - cell adhesion, and the investigators found that suppressing its expression caused CTC clusters to fall apart, reducing their metastatic potential, and also disrupted cell - to - cell contact between breast cancer cells but not normal breast tissue.

Their research, published in PLOS ONE, focused on one particular gene — TRIM29 — selected from a pool of 100 genes with regulatory patterns specific to normal breast tissue, to prove the link between breast - specific genes and the pathology of cancer.

In this particular case, the researchers used DESI mass spectrometry imaging to look at the distribution and amounts of fatty acid substances, called lipids, within breast tissue and normal tissue from 61 samples obtained from 14 breast cancer patients that underwent mastectomy.

A well known example is estrogen, which is involved in the normal differentiation of the breast and also in breast cancer development,» said Dr. Evron, a senior oncologist and a researcher in the lab.

«Normal breast epithelium from the duct giving rise to a breast cancer has not been previously studied in this way.»

«Breast cancer researchers track changes in normal mammary duct cells leading to disease.»

Breast cancer researchers have mapped early genetic alterations in normal - looking cells at various distances from primary tumours to show how changes along the lining of mammary ducts can lead to disease.

The researchers found that several fatty acids, such as oleic acid, were more abundant in breast cancer tissue compared to normal tissue.

The team therefore analyzed the case history of 890 breast cancer patients and found that low Numb - 1 and -2 levels correlated with an increased risk of aggressive, metastatic disease, particularly for the luminal subtype of breast cancers, which tend to retain a normal, functional copy of the p53 gene.

Among postmenopausal women with normal body mass index (BMI), those with higher body fat levels had an increased risk for invasive breast cancer, according to data presented at the American Association for Cancer Research Special Conference Obesity and Cancer: Mechanisms Underlying Etiology and Outcomes, held Jan. 27cancer, according to data presented at the American Association for Cancer Research Special Conference Obesity and Cancer: Mechanisms Underlying Etiology and Outcomes, held Jan. 27Cancer Research Special Conference Obesity and Cancer: Mechanisms Underlying Etiology and Outcomes, held Jan. 27Cancer: Mechanisms Underlying Etiology and Outcomes, held Jan. 27 - 30.

«High body fat levels associated with increased breast cancer risk in women with normal BMI.»

«Our findings show that the risk of invasive breast cancer is increased in postmenopausal women with normal BMI and higher levels of body fat, meaning that a large proportion of the population has an unrecognized risk of developing cancer.»

The study included participants who had a normal BMI (between 18.5 to < 25.0) with baseline DXA measurements and no history of breast cancer.

Iyengar and colleagues also found that the risk of ER - positive breast cancer increased by 35 percent for each 5 - kilogram increase in whole body fat, despite having a normal BMI.

Zeroing in on this kinase was encouraging, Goga said, because other researchers have shown that genetic - knockout mice that lack the entire family of PIM kinases are slightly smaller than normal mice, but «basically fine,» indicating that a drug targeting just PIM1 may have manageable levels of toxicity in breast cancer patients.

The second collection comprised data from 311 manually curated breast cancer and normal samples from The Cancer Genome Atlas repository at the National Institutes of Health cancer and normal samples from The Cancer Genome Atlas repository at the National Institutes of Health Cancer Genome Atlas repository at the National Institutes of Health (NIH).

By manipulating it in vitro, a team of researchers led by Prof. David Mooney at Harvard SEAS have identified a possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer.

Now, results of a new study by Johns Hopkins Kimmel Cancer Center scientists suggests a powerful role for the protein in normal breast cells, acting as a tumor suppressor that halts abnormal cell growth.

The researchers found that over 25 percent of index patients with normal results from commercial testing of BRCA1 and BRCA2, but with families severely affected by breast cancer, could be resolved by sequencing all genes known to be involved in breast cancer.

In some families, the patient who was tested had normal sequences of BRCA1 and BRCA2, but her relatives with breast cancer carried a mutation in one of those genes.

They conducted complete genomic sequencing of all genes implicated in breast cancer on DNA samples from breast cancer patients who had normal BRCA1 and BRCA2 commercial test results.

The 5E5 antibody recognized multiple types of cancer cells, including leukemia, ovarian, breast, and pancreatic cancer cells, but not normal tissues.

The researchers identified a protein, SOCS3, that is highly expressed in normal cells but undetectable in triple - negative breast cancer.

Obesity is associated in general with cancer, but the link with breast cancer is especially striking: In one recent large study, the most overweight women were at a 58 % higher risk than women of normal weight.

The news wasn't all bad: When Fischbach's team put obese mice on a diet, their mammary fat tissue had fewer myofibroblasts, suggesting losing weight could make a woman's fat tissue structure more normal and lower her breast cancer risk.

The research, using cells from the Breast Cancer Now Tissue Bank and due to be published in Nature Communications, also shows that the epigenetic changes are inherited as long as the cell divides, and that the team's manipulations permanently and negatively affected the biology of a normal breast cell from a healthy indivBreast Cancer Now Tissue Bank and due to be published in Nature Communications, also shows that the epigenetic changes are inherited as long as the cell divides, and that the team's manipulations permanently and negatively affected the biology of a normal breast cell from a healthy indivbreast cell from a healthy individual.

Dr. David Gilley's laboratory at the Indiana University School of Medicine in Indianapolis and Dr. Connie Eaves» laboratory at the BC Cancer Agency's Terry Fox Laboratory in Vancouver, Canada, collaborated to determine how telomeres are regulated in different types of normal breast cells.

New research provides critical insights into how normal breast precursor cells may be genetically vulnerable to develop into cancer.

The researchers inserted between 10,000 and 40,000 of these small RNAs at once into breast cancer, colon cancer, and normal human cells in the lab.

Interestingly, the team found that radiologists could do better than chance in discriminating breast cancer cases from normal tissue, even when the images of abnormal breast tissue did not directly capture a cancerous lesion or when those images were taken from the contralateral breast (the breast on the other side of the body) of a woman with breast cancer.

«Radiologists detect breast cancer in «blink of an eye»: Study investigates how trained radiologists are able to distinguish normal from abnormal mammograms when shown images for only half a second.»

This compound killed human breast, prostate, lung, and liver cancer cells, while sparing normal cells.

Quantification of cellular volume and sub-cellular density fluctuations: comparison of normal peripheral blood cells and circulating tumor cells identified in a breast cancer patient.

Cancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficCancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficcancer and inversely correlated with DNA repair deficiency.

It may explain why 77 percent of breast cancers have a normal p53 gene, and it further suggests a way that cancer cells can use both to metastasize and survive the journey to organs where they set up a new home.

The key was the development of a special «birdcage» coil for MRI of the mouse mammary glands, and the team began testing a wide range of protocols to get images that could distinguish between cancer, normal breast tissue and fat.

The team examined premalignant as well as cancer cells from breast and lung tumors and matched normal and premalignant breast cells from healthy women provided by scientists at the University of California San Francisco.

December 20, 2007 Genetic alterations in the benign - appearing stromal cells surrounding breast cancers predict for nodal metastases The cells surrounding breast cancers, called stroma, are benign appearing, «normal» by all accounts.

LA JOLLA, CA — Reviving a theory first proposed in the late 1800s that the development of organs in the normal embryo and the development of cancers are related, scientists at the Salk Institute for Biological Studies have studied organ development in mice to unravel how breast cancers, and perhaps other cancers, develop in people.

Using cutting - edge techniques enabled by next - generation sequencing, the authors generated complete methylome maps at single nucleotide resolution in a low - passage breast cancer cell line and normal breast tissue (primary human mammary epithelial cells).

This is a color - coded view of a normal breast, left, and a breast with cancer, right.

Exposures to chemicals that disrupt these normal processes can alter normal breast development in ways that lead to increased risk of breast cancer in later life.

To evaluate whether altered expression of the ABL genes is associated with breast cancer progression and metastasis, we examined the expression of ABL1 and ABL2 in normal and invasive breast tumor specimens using published TCGA (The Cancer Genome Atlas) data sets (14 &mdashcancer progression and metastasis, we examined the expression of ABL1 and ABL2 in normal and invasive breast tumor specimens using published TCGA (The Cancer Genome Atlas) data sets (14 &mdashCancer Genome Atlas) data sets (14 — 16).