Sentences with phrase «normal cell activity»

Our body also produces toxins through normal cell activity and are known as waste products such as ammonia and lactic acid.

It decreases normal cell activity, constricts blood vessels, numbs nerves and slows down breathing.

The berry is high in vitamins and antioxidants, including various polyphenols - compounds that are believed to mop up the harmful by - products of normal cell activity.

Not exact matches

If we could but restore or bring about the normal functioning of brain cells and nerve tissues, as well as their own subsidiary chemical activity in such cases, then mental life would come flooding back in fullness and richness.

It will be of no use to invent means for impeding the activities responsible for cancerous growth if the same activities are also required for the survival of normal cells.

By comparing the results to cells from paired normal tissue, researchers get a detailed molecular picture of the tumor environment, including the types and activity levels of T cells that are critical to the immunotherapy response.

Taking a closer look, the team found that the onset of sepsis disrupts the normal activity of specific interferons, signaling proteins used for communication between immune system cells.

Flies with hyperactive Rac seemed to forget the association faster than normal, and those with low activity seemed to remember longer — even when odours were introduced that should have distracted the flies or conflicted with their memories (Cell, DOI: 10.1016 / j.cell.2009.12.044).

Cancer cells may produce unique metabolic profiles, in part because they grow very rapidly and have metabolic activity very different from normal cells.

This question has been challenging to address experimentally because attempts to restore function to lost or mutated genes in cancer cells often trigger excess gene activity, causing other problems in normal cells.

Again, the liver cells with suppressed ATPIF1 function dealt better with mitochondrial dysfunction than liver cells with normal ATPIF1 activity.

Because mice lacking both genes would not be born alive, the scientists followed up this lead by making «conditional knockout mice,» in which Esrp1 and Esrp2 activity was normal early in fetal development, but then was switched off in skin epithelial cells.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

Ballabio and his colleagues studied the role of the pathway in two normal cellular activities; how cells respond to physical exercise and how they respond to nutrient availability.

Eventually the dendrites made contact with those of neighboring cells and established normal electrical activity.

«We know that the pathway is important for normal cells to carry their activities as it is involved in regulating metabolism, that is, how cells process nutrients to obtain energy and how cells use energy to grow.

On the other hand, when the researchers blocked f - circRNA activity, the cells» normal behaviors were restored.

Normal and cancerous brain cells interfaced with graphene show different activity levels under Raman imaging.

Based on years of scientific research into the root causes of the condition, the device uses precisely timed sounds and weak electrical pulses that activate touch - sensitive nerves, both aimed at steering damaged nerve cells back to normal activity.

The L1 genes can jump to new positions, disrupting the normal activities of cells if they land in the middle of important genes.

UCLA researchers have found that a Chinese herbal regimen called TSY - 1 (Tianshengyuan - 1) increased telomerase activity in normal blood cells but decreased it in cancer cells.

The compound increases bone mass by protecting and increasing the activity of bone cells in various stages of normal bone mantanence, utilizing mechanisms that overlap those that regulate whole - body energy metabolism.

«A basic level of EGFR activity is required to maintain the normal cell turnover in the gut,» said Petrus de Jong, MD, first author of the study.

«When we put the photoswitched channels into bipolar cells and record the output of the ganglion cells, we see complicated patterns that look a lot like the activity you get in a normal retina, compared to the on - off activity you get when you put the same photoswitch into a ganglion cell,» Isacoff said.

The five - year study, led by UCLA Jonsson Comprehensive Cancer Center member Dr. Jianyu Rao, measured the ability of TSY - 1 to affect telomerase activity in cancer cells lines, including one known as HL - 60, as well as normal peripheral blood mononuclear and hematopoietic stem cells.

The follow up Biosensors paper, provides a proof - of - principle use of these probes as tools to assess and compare GLUT5 and metabolic activity of different cell types, including normal cells and different cancer subtypes.

A cell that is in stress reduces its activity in order to survive with the goal of restoring it to a normal condition after the stress passes.

In normal mice, these neurons — a subset of nerve cells that release the neurotransmitter gamma - amino butyric acid (GABA), and so are called GABAergic neurons — are most active during waking periods when the mice are eating or grooming, two highly pleasurable activities.

Images taken with a fluorescent microscope show the activity of a kinase (green) in tumor cells (bottom) compared to normal cells (top).

As with many other epileptic syndromes, LKS children often resume normal brain activity around age 15, when the brain cells are reaching toward maturation, perhaps spurred by hormonal change.

Molecular profiling of PI cells identified the fly version of DH44 as a circadian molecule that is specifically expressed by PI neurons and required for normal rest / activity rhythms in flies.

Most coveted by the firms are automated systems for analyzing the activities of tens of thousands of genes and proteins in normal and diseased cells.

This «hyperspectral imaging» measures light that cells naturally produce during their normal activities.

The researchers discovered that the activity of this electric signal is necessary in different aspects of normal regeneration, namely for the expression of crucial genes, formation of a mass of cells capable of growth and regenerate, and proper tissue innervation.

«Inhibiting DGKi seems to reverse the effects of cystic fibrosis, but not block ENaC completely,» says Margarida Amaral from the University of Lisboa, «indeed, inhibiting DGKi reduces ENaC activity enough for cells to go back to normal, but not so much that they cause other problems, like pulmonary oedema.»

However, the research showed that when lithium was administered to these cells, their regulatory mechanisms were corrected, restoring normal activity of CRMP2 and correcting the underlying cause of their disorder.

When proteasome inhibitors go into action, Nrf1 is spurred into overdrive to restore the cells» normal activities and keep them alive.

Normal maintenance and cell turnover throughout the planarian body continue unaffected when fst is inhibited, even though these activities rely on the same neoblast cell population that creates new tissue during regeneration.

One even showed greater dopamine activity in the injured side of the brain than on the normal side, indicating, says Jaenisch, that «these IPS cells could be used also for generating function of dopaminergic neurons that could have therapeutic value.»

However, they also revealed that some cell function is significantly lower than normal, or depressed, and some cell activity is heightened.

The «active cell map» is the set of all interactions, complexes and pathways involving molecules in the cell and their activity under normal and diseased regulatory circumstances.

During a seizure, the normal patterns of electrical activity are disrupted, and the cells start to fire at the same pace all at once.

IgG and IgA with potential microbial - binding activity are expressed by normal human skin epidermal cells.

Many scientists now believe that — complementing its initial focus on mutated genes — precision oncology must now also address the activity of otherwise normal proteins and molecular pathways that are ultimately responsible for cancer cells» malignant behavior.

In addition, ActD has been shown to mimic nutlin - 3 in the activation of p53 - dependent transcription, induction of a reversible protective growth arrest in normal cells, and enhancement of the activity of the chemotherapeutic drugs, melphalan and etoposide, resulting in apoptosis of p53 positive human tumor cells [14].

«Our study also highlights that growth of normal cells and cancer cells is driven by different gene switches, suggesting that further work to find ways to control the activity of such disease - specific switches could lead to novel, highly specific approaches for therapeutic intervention», says Professor Jussi Taipale, who led the study.

Song and her team found that in mice, the medial septum - to - hippocampus circuit works to keep DG stem cells in this normal, low - activity state.

So using MM - 401 to block MLL1's normal activity in cells that had started down the path to adulthood meant that histone marks were missing before the cell needed them.

These iPS cells have a normal karyotype, demonstrate telomerase activity and express embryonic stem (ES) cell surface markers.

BCR - ABL's continuous activity stimulates cell - growth pathways and transforms normal cells into ones that proliferate without restraint.