Sentences with phrase «normal cell regulation»

Not exact matches

Telomerase is an enzyme responsible for the production of telomeres, which play an important role in the regulation of normal cell division.

In normal cells, the mTOR pathway can be turned on and off, but in some cancers mTOR becomes impossible to switch off, and the cells are left to grow without any regulation.

This work is one basis for the use in the scientific community of transgenes as a major technique to study gene regulation in normal and malignant cells.

«We are next interested in determining if Bcl - xL's method of self - regulation also occurs when it is embedded in a cell membrane, where Bcl - xL would be found in a normal cell,» Marassi says.

Enhanced hiPS - HEP cells demonstrate normal insulin response and functional glucose regulation.

The mutation they carry alters the regulation of other genes, but which of these prevent AML cells from becoming normal blood - forming cells is largely unknown.

Rather, the defective checkpoint system was left to proceed, and one of its downstream consequences, which was still under normal regulation — and one known to be directly induced by the normal degenerative aging process — was reversed at the structural level, by clearing out the p16Ink4a - positive senescent cells that had accumulated to an abnormal degree in their tissues.

Up - regulation occurs when a cell is deficient in some kind of receptor so that more receptor protein is synthesized and transported to the membrane of the cell and thus the sensitivity of the cell is brought back to normal, reestablishing homeostasis.

His research interests include the biology of papillomaviruses and the regulation of normal and neoplastic cell growth.

Approximately 50 % of PTCL are unclassifiable and categorized as PTCL, not otherwise specified (PTCL - NOS).1 Using gene expression profiling, PTCL - NOS lymphocytes can be distinguished from normal T lymphocytes, with deregulation of genes involved in apoptosis, proliferation, cell adhesion, and transcription regulation.2 Two subgroups of PTCL - NOS have been identified, which are characterized by high expression of either GATA3 or TBX21 / T - bet transcription factors and downstream target genes.3 However, actionable biomarkers closely related to the pathogenic mechanism need to be further investigated and may become potential therapeutic targets of PTCL - NOS. 4, 5

«The efficient production of endoderm represents the first critical step in the creation of a renewable islet source derived from hES cells that is targeted at restoring normal glucose regulation in diabetic patients.»

EGCg has been scientifically demonstrated to assist in maintaining healthy tissues during times of normal metabolic stress and to support proper cell cycle regulation.