Sentences with phrase «normal cells and tissues»

A second hurdle in cancer is to generate an immune response sharply focused on cancer cells while avoiding normal cells and tissues.

Not exact matches

If we could but restore or bring about the normal functioning of brain cells and nerve tissues, as well as their own subsidiary chemical activity in such cases, then mental life would come flooding back in fullness and richness.

The antioxidants in AppleActiv play an important role in neutralizing oxidative damage caused by free radicals, repairing damage and protecting the normal functioning of cells and tissues.

Instead, IsoLove re-hydrates tissue to normal, healthy levels, and helps maintain the integrity of the vaginal cell structure and ecosystem.

Other kinds of congenital anomalies that are sometimes found with this condition are, as previously mentioned, Down Syndrome, shorter intestines than normal, lower birth weight, and an imbalance of electrolytes, which are the elements in the blood, tissue and cell fluid needed to help the person balance their energy.

By comparing the results to cells from paired normal tissue, researchers get a detailed molecular picture of the tumor environment, including the types and activity levels of T cells that are critical to the immunotherapy response.

Cancer cells can break away from a primary tumor, penetrate into lymphatic and blood vessels, circulate through the bloodstream, and grow in a distant focus (metastasize) in normal tissues elsewhere in the body.

The Zika virus can cross the blood - brain barrier, and could target cancer cells, sparing normal adult brain tissue and opening a potential new way to attack the disease.

To determine local immune control, where the invasive tissue interfaces with normal cells, post-birth placentas and stage - four melanoma tumors were examined.

Damaged mouse sciatic nerves produced hundreds of times the normal amount of two «chemoattractant» molecules, Cxcl1 and Cxcl2, which attach to the surfaces of neutrophils and draw the immune cells into injured tissue.

«In normal conditions, skeletal muscle is a self - healing tissue and can recover promptly from most trauma because of the satellite cells.

The goal of stem cell therapy is to replace the damaged tissue with new heart cells and restore the failing heart to normal function.

In a study published in the journal Science, an international collaboration of investigators from Dana - Farber, Harvard Medical School, Boston Children's Hospital, and the University of Strasbourg uncovered a mechanism that allows key immune system cells to keep a steady rein on their more belligerent brother cells, thereby protecting normal, healthy tissue from assault.

Measuring a few millimetres across, the pieces of intestinal tissue made by the month - long process contain all the cells and features found in normal gut tissue, and grow by the same route as in embryos.

When they examined mice genetically incapable of producing Helios, they found the animals beset by a T - cell and antibody attack on normal tissue.

These relatively normal tissue cells communicate with the cancer cells and play a major role in cancer progression, and could offer a new target for treatment.

Expression of CXCL16 was higher in the colon and lung tissue of GF mice than in normal mice, and blocking that expression reduced the numbers of iNKT cells and the amount of inflammation in those tissues.

Matteo Boretto, the first author on this study, commented that «we were very excited to see that we could not only robustly grow and amplify endometrial tissue in a dish, but that the tiny structures were also able to reproduce normal responses of the endometrium to hormones: oestrogen makes the tissue thicken, progesterone then induces maturation including folding (see picture), and subsequent removal of both hormones mimics the cell shedding of the menstrual period.»

In GVHD, donor cells trigger an immune response that attacks normal tissues, leading to a chain reaction of cellular and molecular responses that increase morbidity and mortality in these patients.

Microglia are brain cells that help maintain the integrity and normal functioning of brain tissue.

Auxin controls a range of responses in plants, including cell and tissue growth and normal development.

Plakoglobin is a component of two important structures involved in cell - to - cell adhesion, and the investigators found that suppressing its expression caused CTC clusters to fall apart, reducing their metastatic potential, and also disrupted cell - to - cell contact between breast cancer cells but not normal breast tissue.

And our normal tissues would be preserved intact, provided that we underwent regular rounds of replacement of stem cells.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Besides displaying more natural signaling patterns, 3D cultures allow researchers to mix cell types in ways that mimic their interactions in living tissue, providing more accurate models of normal physiology and pathogenesis.

The off - target antibodies and overdose usage of antibodies can cause side effects such as an autoimmune disorder, which can damage normal tissue cells.»

Turning the gene back on restrains growth and lets the cells develop into normal intestinal tissue (green).

«If you look at a normal tissue,» Shenoy said, «you see the cells are more rounded, and the network of ECM fibers is more random.

In a bid to progress beyond the shotgun approach to fighting cancer — blasting malignant cells with toxic chemicals or radiation, which kills surrounding healthy cells in the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal tissue.

The vlincRNAs were shown to be present in cancerous cells as well as stem cells and normal human tissues.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

«In contrast, in other bodily tissues, the gene was silenced in normal cells and over-expressed in tumors.

«Because the metabolites in cancer and normal cells are so different, we extract and analyze them with the MasSpec Pen to obtain a molecular fingerprint of the tissue.

Subsequent transplant of millions of human T - ALL cells into normal mice that were then treated with an anti-CXCR4 drug induced remission within two weeks, with diseased spleen and bone marrow tissue nearly returning to normal.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

The research suggests that reducing production of the protein, called myoferlin, affects cancer cells in two primary ways: by changing the activation of many genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to other tissues.

While changes in insulin secretion are unlikely to play a major role in the acute effects of SD, cellular stress in pancreatic tissue suggests that chronic SD may contribute to the loss or dysfunction of endocrine cells, and that these effects may be exacerbated by normal aging, say the researchers.

For the first time ever, we could make a really comprehensive comparison of individual normal and tumour cells from the exact same type of tissue, taken at the same time, from the same person, and see how the cancer had developed.»

Senescence is associated with normal aging, and senescent cells accumulate in aged tissues, which impair the normal functions of the tissue and contribute to age - related diseases.

They propose that normal tissue becomes primed for cancer when oncogenes are activated and tumor suppressor genes are silenced or lost, but that cancer develops only when a cell in the tissue reverts to a more primitive, embryonic state and starts dividing.

The team worked on tissue from three patients with colorectal cancer, taking normal bowel stem cells and cells from four different areas of the tumours.

The researchers now want to find out exactly how Tregs interact with fat tissue and whether the immune cells accumulate in other organs during normal aging.

They confirmed low levels of miR - 184 expression in human glioma tissue samples and cultured cell lines as well as an increase in the expression of SND1 compared to normal brain tissue.

What if drugs for cancer, cardiovascular disease, and other diseases can be targeted specifically and only to cells that need the medicine, and leave normal tissues untouched?

He is trying to identify the molecules with which the klotho protein interacts in tissues and to figure out how cells with defective klotho behave differently from normal cells.

These structures were further examined by tissue - level and immunohistochemical tools, revealing ducts with «excessive layers» of epithelial cells, potentially pre-cancerous lesions that were «highly proliferative» compared to normal ducts, they add.

For the new study, described in the October 23rd issue of Nature Communications, scientists at the Johns Hopkins Kimmel Cancer Center and Dana Farber Cancer Institute in Boston collected tissue samples containing normal cells, ovarian cancers, metastases that had spread elsewhere, and small cancers found in the fallopian tubes, which included single cell layers of cancer called «p53 signatures» and serous tubal intraepithelial carcinoma, or STIC lesions.

Working with the brains of six normal children and seven autistic children ages 2 to 16, most of whom died of drowning, Courchesne has studied neurons under the microscope and even counted the number of neural cells in different tissue samples.

This inflammation is important in the normal healing process, affecting tissue growth and blood flow changes that allow the tissue to heal; when the inflammation subsides, skin cells start growing to cover the wound and help the tissue knit together.

In normal cells, this is a part of the wound repair process when PGE2 induces tissues stem cells to regrow; in cancer PGE2 ironically induces regrowth of more cancer stem cells in between chemotherapy cycles, Kurtova and Xiao said.